Article: Floxuridine

Systematic (IUPAC) name
5-fluoro-1-[4-hydroxy-5- (hydroxymethyl)tetrahydrofuran-2-yl]- 1H-pyrimidine-2,4-dione
CAS number 50-91-9
ATC code  ?
PubChem 5790
DrugBank APRD00692
Chemical data
Formula C9H11FN2O5
Mol. weight 246.193 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Floxuridine is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colectoral cancer.


Floxuridine, an analog of 5-Fluorouracil, is a fluorinated pyrimidine.

Meachanism of action

Floxuridine works because it is broken down by the body into its active form, which is the same as a metabolite of 5-Fluorouracil.


Floxuridine first gained FDA approval in December 1970 under the brand name FUDR. The drug was initially marketed by Roche, which also did a lot of the initial work on 5-flurouracil. The National Cancer Institute was an early developer of the drug. Roche sold its FUDR product line in 2001 to Faulding, which became Mayne Pharma.


In the US the drug is supplied by Mayne Pharma as well as APP and Bedford.

Chemotherapeutic agents (L01) edit - Chemotherapy regimens
L01A - Alkylating agents: Cyclophosphamide | Chlorambucil | Melphalan | Mechlorethamine | Ifosfamide | Busulfan | ThioTEPA | Lomustine | Streptozocin | Temozolomide | Dacarbazine | Cisplatin | Carboplatin | Oxaliplatin | Procarbazine | Uramustine
L01B - Antimetabolites: Methotrexate | Pemetrexed | Fludarabine Cytarabine | Fluorouracil | Floxuridine | Gemcitabine | Capecitabine
L01C - Plant alkaloids: Vinblastine | Vincristine | Vinorelbine | Etoposide | Paclitaxel | Docetaxel
L01D - Cytotoxic/antitumour antibiotics: Anthracycline family (Doxorubicin | Daunorubicin | Epirubicin | Idarubicin | Mitoxantrone) | Bleomycin | Mitomycin | Hydroxyurea
L01X - Other, including Topoisomerase inhibitors: Topotecan | Irinotecan
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