Not Signed In -
Hydroxyurea |
Droxia; Hydrea |
Clinical Trial: Chemotherapy, Biological Therapy, and/or Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Chronic Myelogenous Leukemia
This study is currently recruiting patients.
|
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell or bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Interferon alfa may interfere with the growth of cancer cells. It is not yet known if chemotherapy is more effective with or without interferon alfa and/or stem cell or bone marrow transplantation in treating chronic myelogenous leukemia.
PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without biological therapy and/or stem cell transplantation.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| chronic phase chronic myelogenous leukemia Philadelphia chromosome positive chronic myelogenous leukemia Philadelphia chromosome negative chronic myelogenous leukemia childhood chronic myelogenous leukemia atypical chronic myeloid leukemia | Drug: busulfan Drug: cyclophosphamide Drug: cytarabine Drug: etoposide Drug: filgrastim Drug: hydroxyurea Drug: idarubicin Drug: interferon alfa Procedure: allogeneic bone marrow transplantation Procedure: biological response modifier therapy Procedure: bone marrow ablation with stem cell support Procedure: bone marrow transplantation Procedure: chemotherapy Procedure: colony-stimulating factor therapy Procedure: cytokine therapy Procedure: high-dose chemotherapy Procedure: interferon therapy Procedure: peripheral blood stem cell transplantation Procedure: radiation therapy | Phase III |
MedlinePlus related topics: Bone Marrow Diseases; Immune System and Disorders; Leukemia, Adult Acute; Leukemia, Adult Chronic; Leukemia, Childhood; Lymphatic Diseases
Study Type: Interventional
Study Design: Treatment
Official Title: Phase III Randomized Study of Hydroxyurea Cytoreduction Followed By Interferon alfa Versus Allogeneic Stem Cell Transplantation Versus High-Dose Chemotherapy Followed By Autografting and Interferon alfa Maintenance in Patients With Chronic Phase Chronic Myelogenous Leukemia
Further Study Details:
OBJECTIVES:
- Compare survival in patients with chronic myelogenous leukemia in early chronic phase treated with allogeneic bone marrow transplantation vs drug treatment with or without autologous peripheral blood stem cell transplantation.
- Compare survival of patients with late-phase disease treated with high-dose cytarabine vs low-dose cytarabine followed by autografting and interferon alfa maintenance.
- Compare survival of patients not responding cytogenetically to treatment with continued interferon alfa vs hydroxyurea.
- Determine frequency, time-point, and duration of hematological and cytogenetic remissions and of Philadelphia chromosome-negative and/or BCR-ABL-positive cells on the various treatments.
- Correlate the quality of hematological and cytogenetic remissions with survival time in patients treated with these regimens.
- Compare the course of the terminal phase in patients treated with these regimens.
- Compare the toxic effects of these regimens in these patients.
- Determine the effect of prognostic criteria and normal or subnormal WBC on chronic phase duration and survival time in patients treated with these regimens.
- Compare the effect of early vs late high-dose therapy plus autografting on feasibility, toxicity, and survival times in these patients.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to eligibility for transplantation (yes vs no).
All patients undergo cytoreduction comprising hydroxyurea (HU) IV daily.
Patients who are ineligible for or refuse transplantation are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive interferon alfa (IFN) subcutaneously (SC) daily. After 2 weeks of IFN therapy, patients also receive low-dose cytarabine (ARA-C) SC once daily for 10-15 days each month. Patients who do not achieve cytogenetic remission within 12 months continue to receive HU.
- Arm II: Patients receive IFN SC daily. After 2 weeks of IFN therapy, patients also receive low-dose ARA-C SC daily for 10-15 days each month. Patients who do not achieve cytogenetic remission within 12 months continue to receive IFN therapy SC daily. Patients who are eligible for transplantation with a related donor undergo allogeneic bone marrow transplantation. Patients may receive HU or IFN prior to transplantation. Patients may also receive oral high-dose busulfan daily for 4 days with or without cyclophosphamide or cyclophosphamide with total body irradiation.
Patients who are eligible for transplantation but do not have a related donor undergo peripheral blood stem cell (PBSC) harvest and are randomized to 1 of 2 treatment arms.
- Arm III: Patients receive IFN and low-dose ARA-C as in arm I. Patients who accelerate on treatment may undergo autologous PBSC transplantation.
- Arm IV: Patients receive idarubicin IV, ARA-C IV over 2 hours, and etoposide IV on days 1-3. Patients then undergo leukapheresis. Beginning on day 8, patients receive filgrastim (G-CSF) SC daily until end of leukapheresis. Patients then receive oral high-dose busulfan daily for 4 consecutive days. The following day, patients undergo reinfusion of autologous PBSC. After blood count recovery, patients receive maintenance IFN 3 times weekly for 8 weeks and then daily. Patients are followed every 3 months for 3 years and then every 6 months thereafter.
PROJECTED ACCRUAL: A total of 1,000 patients will be accrued for this study within 5 years.
Eligibility
Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of chronic myelogenous leukemia in chronic phase
- Previously untreated
- Patients negative for Philadelphia chromosome and BCR-ABL translocation must fulfill at least 1 of the following criteria:
- Impaired health status with reduced exercise tolerance
- Spleen-related symptoms in cases of splenomegaly
- Weight loss greater than 10% in 6 months
- Fever greater than 38.5 degrees C on 5 consecutive days
- Clinically relevant bone pain
- Leukocytosis greater than 5,000/mm^3
- Thrombocytosis greater than 100,000/mm^3
PATIENT CHARACTERISTICS: Age:
- Any age
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- See Disease Characteristics
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- No other concurrent malignancy that is likely to require treatment during study or that is likely to reduce life expectancy
- No severe concurrent disease or other cause that would preclude study
- Not pregnant
PRIOR CONCURRENT THERAPY: Biologic therapy:
- No prior interferon
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- Not specified
Radiotherapy:
- No prior radiotherapy
Surgery:
- Not specified
Location and Contact Information
Czech Republic
Masaryk University Hospital, Brno, 62500, Czech Republic; Recruiting
J. Mayer, MD 420-5-3223-3643 jmayer@fnbrno.cz
Germany
Allgemeines Krankenhaus Altona, Hamburg, 22763, Germany; Recruiting
Contact Person 49-40-8822-0
Allgemeines Krankenhaus Hagen, Hagen, D-58095, Germany; Recruiting
Theo Scholten, MD 49-23-31-201-2247
Barmbek General Hospital, Hamburg, D-22291, Germany; Recruiting
Ulrich Muellerleile, MD 49-40-6385-3877 umuellerleile@web.de
Bundeswehr Krakenhaus, Ulm, D-89070, Germany; Recruiting
Alfred P. Schoengen, MD 49-731-17-100
Caritas - Krakenhaus Lebach, Lebach, 66822, Germany; Recruiting
Dieter Hufnagl, MD 49-6881-501-200
Caritasklinik St. Theresia, Saarbrucken, D-66113, Germany; Recruiting
Joachim Preiss, MD, PhD 49-681-406-1100 j.preiss@caritasklinik.de
Charite - Campus Charite Mitte, Berlin, D-10117, Germany; Recruiting
Kurt Possinger, MD 49-30-2802-2228 kurt.possinger@charite.de
Charite - Campus Virchow Klinikum, Berlin, D-13353, Germany; Recruiting
Contact Person 49-30-30-350
Clinic for Bone Marrow Transplantation and Hematology and Oncology, Idar-Oberstein, D-55743, Germany; Recruiting
Axel Arthur Fauser, MD, PhD 49-6781-66-1580
Department of Medicine III, Erlangen, D-91054, Germany; Recruiting
J R Kalden, MD 49-9131-85-334-18
Deutsche Klinik fuer Diagnostik, Wiesbaden, D-65191, Germany; Recruiting
Rainer Schwerdfeger, MD, PhD 49-611-577-207 kmt@dkd-wiesbaden.de
Diakonissen - Krankenhaus, Karlsruhe-Rueppur, 76199, Germany; Recruiting
S Domschke, MD 49-721-889-2678
Diakonissen-Krankenhaus Stuttgart, Stuttgart, D-70176, Germany; Recruiting
Else G. Heidemann, MD 49-711-991-3501
DR Herbert - Nieper Krankenhaus Goslar, Goslar, 38642, Germany; Recruiting
Andreas Hoyer, MD 49-5321-555-401
Eberhard Karls Universitaet, Tuebingen, D-72076, Germany; Recruiting
Lothar Kanz, MD 49-7071-298-2726 lothar.kanz@med.uni-tuebingen.de
Europahochhaus, Bochum, 44787, Germany; Recruiting
Ute Bueckner, MD 9 62 03 90
Evangelische Krankenhaus Hamm, Hamm, DOH-59063, Germany; Recruiting
Albert Grote-Metke, MD 2381-589-1332 agrote-metke@evkhamm.de
Evangelisches Krankenhaus Essen Werden, ESSEN, D-45239, Germany; Recruiting
Franz-Karl Baur, MD 49-201-4089-2099
Facharzt Fuer Jnnere Medizin, Karlsruhe, 76135, Germany; Recruiting
Franz A. Mosthaf, MD 49-721-853-505
Franziskus Hospital, Bietigheim, 74321, Germany; Recruiting
S Walker, MD, Prof 49-7142-795050
Gemeinschaftspraxis Brunoehler, Oberhausen, 46045, Germany; Recruiting
A. Brunoehler, MD 0208-209-197
Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie, Ansbach, 91522, Germany; Recruiting
Sebastian Mueller, MD 49-981-97-0790 onkologie-anshach@t-online.de
Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie, Giessen, 35392, Germany; Recruiting
Andreas Kaebisch, MD 49-641-920-3190 schliesser.kaebisch@t-online.de
Gemeinschaftspraxis Innere Medizin, Jena, D-07743, Germany; Recruiting
Ruffert, MD 49-36-415-6246
Gemeinschaftspraxis, Munich, 80331, Germany; Recruiting
W. Kaboth, MD 49-89-2916-3549
Gemeinschaftspraxis, Niddatel-IIbenstadt, 61194, Germany; Recruiting
H Lukas, MD 49-6034-5018
Gemeinschaftspraxis, Mannheim, D-68161, Germany; Recruiting
Ute Queisser, MD 49-721-889-2678
Gemeinschaftspraxis, Nuernberg, D-90402, Germany; Recruiting
M. Chauer, MD 49-9112-2910
Haematologie Und Internistische Onkologie, Hanau, 63450, Germany; Recruiting
G Lautenschlaeger, MD 49-6181-25-5535
Haematologisch Onkologische Praxis, Aachen, 52070, Germany; Recruiting
Ursula Essers, MD 49-241-50-0051
Haematologische / Onkologische Schwerpunktpraxis, Krefeld, 47798, Germany; Recruiting
M Neise, MD 0049-2151-978674 onko-krefeld@telemed.de
Haematologische Praxis, Augsburg, 86150, Germany; Recruiting
Hans Rainer Slawik, MD 49-821-513143
Haematologische Praxis, Stuttgart, D-70173, Germany; Recruiting
Gregor Springer, MD 49-711-222-0244
Haematologisch-Onkologische Praxis Altona, Hamburg, D-22767, Germany; Recruiting
Ulrich R. Kleeberg, MD, PhD 49-40-3802-1260 urkleeberg@hopa-hamburg.de
Haematologisch-Onkologische Schwerpunktpraxis, Berlin, 13357, Germany; Recruiting
Ilona Blau, MD 49-30-461-4857
Hans - Susemihl - Krankenhaus, Emden, 26721, Germany; Recruiting
H. Becker, MD 4921 98 1295 h.becker@hsk-emden.de
Helios Klinikum Berlin, Berlin, 13122, Germany; Recruiting
W. Dorffel, MD 49-30-9407-2359 hodgkinped@cecon.de
Helios Klinikum Wuppertal, Wuppertal, D-42283, Germany; Recruiting
Aruna Raghavachar, MD, PhD 49-202-896-3351 araghavachar@wuppertal.helios-kliniken.de
Hematologisch - Onkologische Praxis, Wuerselen, 52146, Germany; Recruiting
Christoph Maintz, MD 49-2405-421-422
Hematologische Onkologische Praxis, Regensburg, 93047, Germany; Recruiting
Robert Dengler, MD 49-941-566-342 robert.dougler@t-online.de
Hematologische Praxis, Oldenburg, 26121, Germany; Recruiting
Hans Fokke-Hinrichs, MD 49-441-973-6229
Hermann - Holthusen Institute for Radiotherapy, Hamburg, D-20099, Germany; Recruiting
Rolf Kuse, MD 49-40-2890-2361
II Medizinische Klinik, Fuerth, 90766, Germany; Recruiting
Michael Fink, MD 49-911-7580-1155 onkologie@klinikum-fuerth.de
II. Medizinische Klinik, Aschaffenburg, RG 63739, Germany; Recruiting
Wolfgang Fischbach, MD 49-6021-32-3010 wolfgang.fischbach@klinikum-aschaffenburg.de
III Medizinische Klinik Mannheim, Mannheim, D-68305, Germany; Recruiting
Ruediger Hehlmann, MD 49-621-383-4115 Ruediger.Hehlmann@med3.ma.uni-heidelberg.de
Internistiche Praxis, Erfurt, 99084, Germany; Recruiting
Ulrich Hauch, MD 49-361-260-1106 uhauch.onco@web.de
Jakobi Krankenhaus, Rheine, 48431, Germany; Recruiting
D Bauer, MD 05971/46-0
Kinderklinik Aachen, Aachen, 52074, Germany; Recruiting
R. Mertens, MD, PhD 0049-241-8089902 rmertens@ukaachen.de
Kinderklinik der Freier Universitaet Berlin, Berlin, D-14059, Germany; Recruiting
R. Fengler, MD
Klinik fuer Onkologie - Katharinenhospital Stuttgart, Stuttgart, D-70174, Germany; Recruiting
Hans-Guenther Mergenthaler, MD 49-711-278-5601 h.mergenthaler@katharinehospital.de
Klinik fuer Radioonkologie und Strahlentherapie, Goeppingen, 73035, Germany; Recruiting
Eberhard Kurrle, MD 49-7161-640
Klinik Konstanz, Konstanz, 78461, Germany; Recruiting
Dieter Hardt, MD 49-7531-801-1651
Klinik und Poliklinik fuer Kinderheilkunde - Universitaetsklinikum Muenster, Muenster, D-48129, Germany; Recruiting
B. Rath, MD 49-251-834-7784
Kliniken St. Antonius, Wuppertal 2, D-42283, Germany; Recruiting
Matthias Sandmann, MD 49-202-299-2591 sandmann@antonius.de
Klinikum Coburg, Coburg, 96450, Germany; Recruiting
Diethard Eichmann, MD 49-9561-22-5547
Klinikum der Friedrich-Schiller Universitaet Jena, Jena, D-07740, Germany; Recruiting
Klaus Hoeffken, MD 49-3641-939-100 ilh@rz.uni-jena.de
Klinikum Der Hansestadt Stralsund - Klin. West, STRALSUND, D-18410, Germany; Recruiting
Thomas Heinz Ittel, MD 49-3831-35-2700 medizinische.klinik@klinikum-stralsund.de
Klinikum der J.W. Goethe Universitaet, Frankfurt, D-60590, Germany; Recruiting
Dieter Hoelzer, MD 49-69-6301-5194
Klinikum der Stadt Ludwigshafen am Rhein, Ludwigshafen am Rhein, D-67063, Germany; Recruiting
Michael J. Uppenkamp, MD 49-621-503-3900 UppenKamM@klilu.de
Klinikum Der Stadt Villingen - Schwenningen, Villingen-Schwenningen, D-78054, Germany; Recruiting
Hans Tesch, MD 49-7721-934-000
Klinikum der Universitaet Regensburg, Regensburg, D-93053, Germany; Recruiting
Reinhard Andreesen, MD 49-941-944-5001 reinhard.andreesen@klinik.uni-regensburg.de
Klinikum Erfurt, Erfurt, 99089, Germany; Recruiting
D. Kuestner, MD +49-361-781-3400 dkuestner@erfurt.helios-kliniken.de
Klinikum Garmisch - Partenkirchen, Garmisch-Partenkirchen, N 82467, Germany; Recruiting
Helmut Lambertz, MD 49-8821-77-1520 helmut.lambertz@klinikum-gap.de
Klinikum Grosshadern der Ludwig-Maximilians Universitaet Muenchen, Munich, D-81377, Germany; Recruiting
Wolfgang Hiddemann, MD, PhD 49-89-7095-2551
Klinikum Kassel, Kassel, D-34125, Germany; Recruiting
Contact Person 49-0561-980-3051
Klinikum Kempten Oberallgaeu, Kempten, 87439, Germany; Recruiting
Otto Pruemmer, MD 49-831-530-2226 otto.pruemmer@klinikum-kempten.de
Klinikum Krefeld GmbH, Krefeld, D-47805, Germany; Recruiting
Manfred Planker, MD 49-215-132-2780 planker_med@klinikum-krefeld.de\
Klinikum Lippe - Lemgo, LEMGO, D-32657, Germany; Recruiting
Hans-Peter Lohrmann, MD 49-5261-26-4123
Klinikum Minden, Minden, D-32423, Germany; Recruiting
Heinrich Bodenstein, MD 49-571-801-4810 heinrich.bodenstein@klinikum.minden.de
Klinikum Nuernberg - Klinikum Nord, Nuernberg, D-90419, Germany; Recruiting
Christiane Falge, MD 49-911-398-2460
Klinikum Nuernberg - Klinikum Sued, Nuernberg, D-90471, Germany; Recruiting
W Brockhaus, MD 911-398-0
Klinikum Oldenburg, Oldenburg, D-26133, Germany; Recruiting
Hans J. Illiger, MD 49-441-403-2611 illiger.h.j@klinikum-oldenburg.de
Klinikum Rechts Der Isar - Technische Universitaet Muenchen, Munich, D-81675, Germany; Recruiting
Christian Peschel, MD 49-89-4140-4111 christian.peschel@lrz.tu-muenchen.de
Klinikum Remscheid GMBH, Remscheid, 42859, Germany; Recruiting
Arthur Wehmeier, MD 49-21-9113-3900
Klinikum St. Marien, Amberg, D-92224, Germany; Recruiting
Koellinger, MD 49-9621-380
Krankenhaus Bietigheim, Bietigheim, 74321, Germany; Recruiting
S Walker, MD, Prof 49-7142-795050
Krankenhaus D Barmherzigen Brueder, Regensburg, 93049, Germany; Recruiting
Ernst D Kreuser, MD 49-941-369-2151
Krankenhaus Dueren, Dueren, 52351, Germany; Recruiting
Marianne Engels, MD 49-421-30-1363
Krankenhaus Hohe Warte Mediziniche Klinik, Bayreuth, 95445, Germany; Recruiting
D Seybold, MD
Krankenhaus Maria Hilf GmbH, Moenchengladbach, DOH-41063, Germany; Recruiting
H. E. Reis, MD 49-2161-892-2200
Krankenhaus Muenchen Neuperlach, Munich, D-81737, Germany; Recruiting
Manfred Garbrecht, MD 49-89-6794-2451
Krankenhaus Muenchen Schwabing, Munich, 80804, Germany; Recruiting
Christoph Nerl, MD, PhD 89-3068-2228
Krankenhaus Neukoelln, Berlin, D-12313, Germany; Recruiting
Andreas Grueneisen, MD 49-30-6004-2251 andreas.grueneisen@vivantes.de
Krankenhaus Siloah - Medizinische Klinik II, Hannover, D-30449, Germany; Recruiting
Hartmut Kirchner, MD 49 511 9272801 siloahcc@hannover.sgh-net.de
Krankenhaus St. Michael, Voeklingen, 66333, Germany; Recruiting
D Woerdehoff, MD 06898-17411
Kreiskrankenhaus Boeblingen, Boeblingen, 71032, Germany; Recruiting
Axel Ohmenhaeuser, MD 49-7031-668-0
Kreiskrankenhaus Fuessen, Fuessen, 87629, Germany; Recruiting
Heinrich Kremer, MD 836-250-0366
Kreiskrankenhaus Mellrichstadt, Mellrichstad, DT-97638, Germany; Recruiting
Klaus Wutke, MD 49-9776-6020
Kreiskrankenhaus Radebeul, Radebeul, D-01445, Germany; Recruiting
H J Schulze, MD 0049 0 351 8333333
Kreiskrankenhaus Siegen, Siegen, D-57076, Germany; Recruiting
F. A. Trux, MD 49-271-705-1201
Kreiskrankenhaus, Waldroel, 51545, Germany; Recruiting
H. J. Bias, MD 22 91/8 20
Kreiskrankenhaus, Aalen, 73430, Germany; Recruiting
J.D. Faulhaber, MD 49-921-2800
Kreiskrankenhaus, Bad Hersfeld, 36251, Germany; Recruiting
P J Majunke, MD 49-6621-881779
Kreiskrankenhaus, Herford, D-32049, Germany; Recruiting
Ulrich Schmitz-Huebner, MD 49-522-194-2430 prof.schmitz_huebner@klinikum-kreis-herford.de
Luisenkrankenhaus, Lindenfels, 64678, Germany; Recruiting
Fiez, MD 49-6255-301-1809
Malteser Krankenhaus, Flensburg, D-24939, Germany; Recruiting
Johannes G. Saal, MD 461-816-2512
Marienhospital Bottrop, Bottrop, D-46236, Germany; Recruiting
Eugen Musch, MD 49-2041-106-1501
Medizinische Hochschule Hannover, Hannover, D-30625, Germany; Recruiting
Arnold Ganser, PhD, MD 49-511-532-3020 ganser.arnold@mh-hannover.de
Medizinische Kl. Klinikum Innenstadt Universitaet Muenchen, Munich, D-80336, Germany; Recruiting
Detlef Schloendorff, MD 49-89-516-022-05
Medizinische Klinik Am Lukas - Krankenhaus, Buende, 32257, Germany; Recruiting
D Brunswig, MD 49-52231670
Medizinische Klinik I, Dresden, D-01307, Germany; Recruiting
Gerhard Ehninger, MD 49-351-458-4190 gerhard.ehninger@uniklinikum-dresden.de
Medizinische Poliklinik, Bonn, D-53111, Germany; Recruiting
H Vetter, MD 49-228-287-2263 stefan.frouhotts@uni-bonn.de
Medizinische Universitaetsklinik I, Cologne, D-50924, Germany; Recruiting
Volker Diehl, MD 49-221-478-7408 v.diehl@uni-koeln.de
Medizinische Universitaetsklinik und Poliklinik, Heidelberg, 69115, Germany; Recruiting
Anthony D. Ho, MD, PhD 49-6221-56-8001 anthony_ho@med.uni-heidelberg.de
Michael Schaefers und Partner, Duisburg, D-47051, Germany; Recruiting
Michael Schaefers, MD 49-203-28-41-77
Mutterhaus der Borromaerinnen, Trier, D-54219, Germany; Recruiting
Michael Clemens, MD 49-651-947-2377 clemens@uni-trier.de
Onkolog - Haematolog Schwerpunktpraxis, Berlin, D-10559, Germany; Recruiting
Ingrid Weissenfels, MD 49-30-394-2003
Onkolog Gemeinschaftspraxis, Frankfurt, 60389, Germany; Recruiting
Manfred Fischer, MD 49-69-451-080
Onkologische Praxis Lueneburg, Lueneburg, D-21335, Germany; Recruiting
Bernhard Goldmann, MD +49-4131-855-688 dr.goldmann@freenet.de
Onkologische Schwerpunkt Praxis, Erlangen, 91052, Germany; Recruiting
M.J. Eckart, MD 0049-9131-76250
Onkologische Schwerpunktpraxis Bielefeld, Bielefeld, D-33602, Germany; Recruiting
Erhardt Schaefer, MD 49-521-137-930
Onkologische Schwerpunktpraxis Leer, Leer, D-26789, Germany; Recruiting
Lothar Mueller, MD 49-491-987-910 Lothar.Mueller@onkologie-leer.de
Onkologische Schwerpunktpraxis, Cottbus, D-03046, Germany; Recruiting
Ulrich von Gruenhagen, MD 035-579-7170
Onkologischer Schwerpunkt Lerchenfeld, Hamburg, D-22081, Germany; Recruiting
Andreas Mohr, MD 0049-40-2271800 andreasmohr@t-online.de
Paracelsas Klinik Osnabrueck, Osnabrueck, D-49076, Germany; Recruiting
Olaf M. Koch, MD, PhD 49-541-966-3040 omkoch@aol.com
Philipps-Universitaet Marburg Klinikum, Marburg, D-35033, Germany; Recruiting
Andreas Neubauer, MD 49-6421-28-66273 neubauer@mailer.uni-marburg.de
Praxis am Evangelischen Krankenhaus Bethanien, Iserlohn, D-58644, Germany; Recruiting
Juergen Kemper, MD 011- 492-3712-0007
Praxis DR. J. Weniger, Erfurt, D-99085, Germany; Recruiting
J Weniger, MD 49-361-566-7819
Praxis Fuer Haematologie Internistische Onkologie, Koeln, D-50677, Germany; Recruiting
Stephan Schmitz, MD 49-221-931-8220 schmitz@oncokoeln.de
Praxis fuer Haematologie und Interne Onkologie, Norderstedt, 22844, Germany; Recruiting
Ruediger Hoffmann, MD 49-40-526-5060 dr.r.hoffmann.norderstedt@t-online.de
Praxis Fuer Haematologie/Onkologie, Luebeck, 23560, Germany; Recruiting
Claus Engelmann, MD 49-451-55039 EngelmannCR@T-online.de
Praxis Fuer Haemotologie Und Internistischer Onkologie, Wuppertal, 42105, Germany; Recruiting
Werner Fett, MD 49-202-449-232 fett-onkologe@t-online.de
Praxis fuer Innere Medizin und Haematologie, Munich, D-80797, Germany; Recruiting
Clemens Scheidegger, MD 49-089-129-2054 scheidegger@web.de
Praxis Fuer Internistische Haematologie / Onkologie, Troisdorf, 53840, Germany; Recruiting
Helmut Forstbauer, MD 49-2241-801-871
Praxis Gemeinschaft, Koeln, D-50676, Germany; Recruiting
Rudolf Zankovich, MD, PR 49-221-203-7121
Praxisgemeinschaft, Tuebingen, 72070, Germany; Recruiting
Swen H. Jacki, MD 49-7071-5678-88
Prosper-Hospital Recklinghausen, Recklinghausen, D-45659, Germany; Recruiting
Carl Peter Sodomann, MD 49-02361-54-2651
Trier, D-54290, Germany; Recruiting
Bernhard Rendenbach, MD 49-651-493-93 info@straurenlau.de
Robert-Bosch-Krankenhaus, Stuttgart, 70376, Germany; Recruiting
Walter Aulitzky, MD 49-711-8101-3506 walter.aulitzky@rbk.de
Ruppiner Klinikum GMBH, Neuruppin, 16816, Germany; Recruiting
D Nuernberg, MD 49-221-203-7120
Saechsische Schweiz Klinik, Sebnitz, D-01855, Germany; Recruiting
Ernst-Udo Radke, MD +49-35971-61541 eu.radke@klinik-sebnitz.de
Schwerpunktpraxis Fuer Haematologie Und Onkologie, Saarbruecke, N-66113, Germany; Recruiting
Joerg Schimke, MD 0049 681 473575
St Elisabeth Krankenhaus, Ravensburg, 88191, Germany; Recruiting
Gerhard Meuret, MD 49-751-870
St Marienkrankenhaus, Ludwigshafen, Rhein, D-67067, Germany; Recruiting
H Weis, MD 49-621-5501-2254
St. Antonius Hospital, Eschweiler, DOH-52249, Germany; Recruiting
Roland Fuchs, MD 49-240-376-1280 info@onkologie-eschweiler.de
St. Hedwig Kranken Haus, Berlin, 10115, Germany; Recruiting
Christian Boewer, MD 49-30-2311-2255
St. Irmgardis Krankenhaus, Viersen-Suechteln, 41749, Germany; Recruiting
H. R. Milstrey, MD 49-2162-89-9301 dr.milstrey@st-irmgardis.de
St. Johannes Hospital - Medical Klinik II, Duisburg, D-47166, Germany; Recruiting
Carlo Aul, MD 49-203-546-2480
St. Joseph Hospital, Bremerhaven, N-27568, Germany; Recruiting
HansHeinrich Heidtmann, MD, PhD 471-480-5680 heidtmann@st.joseph-hospital.de
St. Marien - Krankenhaus Siegen GMBH, Siegen, D-57072, Germany; Recruiting
Winfried Gassmann 0271 231 2260
St. Marien Hospital at Katholisches Krankenhaus hagen gem. GmbH, Hagen, 58095, Germany; Recruiting
Hartmut Eimermacher, MD 49-2331-129-250 h.eimermacher@kkh-hagen.de
St. Marien-Hospital Hamm - Klinik Knappenstrasse, Hamm, D-59071, Germany; Recruiting
Heinz Albert Duerk, MD, PhD 49-2381-18-22-51 heinz.duerk@marienhospital-hamm.de
St. Willehad Hospital, Wilhelmshaven, D-26382, Germany; Recruiting
Wiprecht Augener 49-4421-208-0
Stadt. KH Dresden - Neustadt, Dresden, 01129, Germany; Recruiting
Renate Huhn, MD 49-35-856-2220
Staedt Klinikum Karlsruhe GGMBH, Karlsruhe, 76133, Germany; Recruiting
Joerg Th Fischer, MD 49-721-974-3001 haematologie@klinikum-karlsruhe.de
Staedt Krankenhaus, Sebnitz, D-01855, Germany; Recruiting
Kurt Ranft, MD
Staedtisches Klinikum Braunschweig, Braunschweig, D-38114, Germany; Recruiting
Bernhard Woermann, MD 49-531-595-3224 b.woermann@klinikum-braunschweig.de
Staedtisches Krankenhaus Muenchen - Harlaching, Munich, D-81545, Germany; Recruiting
Reiner C. Hartenstein, MD, PhD 01149-89-6210-2731 R.Hartenstein@t-online.de
Staedtisches Krankenhaus, Pforzheim, 75175, Germany; Recruiting
Theilmann, MD 49-7231-969-612 lorenz.theilmann@dgn.de
Tumorzentrum Berlin - Moabit e.V., Berlin, 10967, Germany; Recruiting
Klaus-Peter Hellriegel, MD 49-30-6972-2100 klau-peter.hellriegel@vivantes.de
Universitaet Ulm, Ulm, D-89075, Germany; Recruiting
E Kohne, MD 49-73-1500-27601
Universitaetklinikum Des Saarlandes, St. Ingbert, 66386, Germany; Recruiting
St. Kremers, MD 49-6841-16-23-001
Universitaets - Kinderpoliklinik, Muenchen, 80336, Germany; Recruiting
Detlef Schloendorff, MD 48-89-5160-3500
Universitaetsklinik Duesseldorf, Duesseldorf, D-40225, Germany; Recruiting
Rainer Haas, MD 49-211-811-7720 haem-onk.haas@med.uni-duesseldorf.de
Universitaetsklinikum Bonn, Bonn, D-53105, Germany; Recruiting
I. G. H. Schmidt-Wolf, MD 49-228-287-5489
Universitaetsklinikum Essen, ESSEN, D-45122, Germany; Recruiting
Ulrich Wilhelm Schaefer, MD 49-201-723-2321
Universitaetsklinikum Freiburg, Freiburg, D-79106, Germany; Recruiting
Juergen Finke, MD 49-761-270-3408 finke@mm11.ukl.uni-freiburg.de
Universitaetsklinikum Goettingen, GOETTINGEN, D-37075, Germany; Recruiting
Frank Griesinger, MD, PhD 49-551-39-6303 fgriesi@gwdg.de
Universitaetsklinikum Ulm, Ulm, D-89081, Germany; Recruiting
Hartmut Doehner, MD 49-731-5002-4400 hartmut.doehner@medizin.uni-ulm.de
Universitaets-Krankenhaus Eppendorf, Hamburg, D-20246, Germany; Recruiting
D.K. Hossfeld, MD 49-40-428-032-960 dk.hossfeld@uke.uni-hamburg.de
Universitatsklinik - Saarland, Homburg, D-66421, Germany; Recruiting
Michael G.M. Pfreundschuh, MD 49-6841-162-3084
University Hospital Schleswig-Holstein - Kiel Campus, Kiel, D-24105, Germany; Recruiting
Frank Gieseler, MD 49-431-597-1393
Urologische Klinik - Universitaetsklinikum Aachen, Aachen, D-52074, Germany; Recruiting
Susanne Handt, MD 49-241-808-9377
Urologische Klinik, Giessen, D-35392, Germany; Recruiting
Hans Pralle, MD, PhD 49-641-994-2650 hans.pralle@innere.med.uni-giessen.de
Vincentius Krankenhaus, Karlsruhe, D-76137, Germany; Recruiting
J. Mezger 49-721-8108-3014
Vinzentiuskrankenhaus, Landau, D-76829, Germany; Recruiting
Martin Schroeder, MD 49-6341-17-2200 m.schroeder@vinzentius.de
Munich, 80637, Germany; Recruiting
S. Voelkl, MD 49-89-155-200
Wenckebach - Krankenhaus, Berlin, 12099, Germany; Recruiting
Reinhard Musch, MD 0049 30 7561-2992 reinhard.musch@vivantes.de
Munich, D-81241, Germany; Recruiting
Annebaerbl Wohlrab, MD 49-89-820-1313
Zentralklinikum Augsburg, Augsburg, DOH-86156, Germany; Recruiting
Gunter Schlimok, MD 49-821-400-2353
Zentralkrankenhaus, Bremen, D-28205, Germany; Recruiting
H. Rasche, MD 49-421-497-5240
Zentralkrankenhaus, Bremerhaven, N 27574, Germany; Recruiting
Manegold, MD 49-471-2990
Poland
Medical University of Gdansk, Gdansk, 80-211, Poland; Recruiting
A A Hellmann, MD (11-48 58) 349 22 30
Silesian Medical Academy, Katowice, 40-029, Poland; Recruiting
Jerzy Holowiecki, MD, PhD 48-32-256-2858 holow@slam.katowice.pl
Spain
Hospital Universitario "Virgen de la Victoria" Malaga, Malaga, 29010, Spain; Recruiting
Emilio Alba Conejo 34-95-103-20-00 ext. 99
Switzerland
Bezirksspital Dornach, Dornach, CH-4143, Switzerland; Recruiting
Karl A. Steuer, MD 41-61-704-4346 gastmed_do@spital.ktso.ch
Centre Hospitalier Universitaire Vaudois, Lausanne, CH-1011, Switzerland; Recruiting
Tibor Kovacsovics, MD 41-21-314-4222 tibor.kovacsovics@chuv.hospvd.ch
Facharzt FMH Fuer Innere Medizin and Oncology, Baar, CH-6340, Switzerland; Recruiting
Meinrad Mannhart, MD 41-49-763-1122 mannhart.harms@bluewin.ch
Facharzt Fuer Onkologie-Hematologie, Bern, 3013, Switzerland; Recruiting
Guido Brun Del Re, MD 41-31-331-0092
FMH f. Innere Medizin and Hematologie, Grosshochstetten, 3506, Switzerland; Recruiting
Beatrice Galliker-Vondach, MD 41-31-712-0001
Hopital Cantonal Universitaire de Geneve, Geneva, CH-1211, Switzerland; Recruiting
Sarah Mach-Pascual 41-22-372-9870
Inneremedizin FMH, Breitenbach, 4226, Switzerland; Recruiting
Raphael Haberthuer, MD 41-61-781-1925
Inselspital, Bern, Bern, CH-3010, Switzerland; Recruiting
Bernhard Laemmle, MD 41-31-632-3393
Institut Central des Hopitaux Valaisans, Sion, CH1951, Switzerland; Recruiting
M Stalder, MD 41-27-603-4786
Kantonspital Aarau, AARAU, 5001, Switzerland; Recruiting
Mario Bargetzi, MD 41-62-838-6050 mario.bargetzi@ksa.ch
Kantonsspital - St. Gallen, St. Gallen, CH-9007, Switzerland; Recruiting
Thomas Cerny, MD 41-71-494-1062 thomas.cerny@kssg.ch
Kantonsspital, Luzerne, Luzerne, CH-6016, Switzerland; Recruiting
W A Wuillemin, MD 41-41-205-5147
Klinik Hirslanden, Zurich, CH-8008, Switzerland; Recruiting
Albert von Rohr, MD 41-1-387-3780 avonrohr@onkozentrum.ch
Oncology Institute of Southern Switzerland, Bellinzona, CH-6500, Switzerland; Recruiting
Franco Cavalli, MD 41-91-250-333
UniversitaetsSpital, Zurich, CH-8091, Switzerland; Recruiting
Alexander Knuth, MD 41-1-255-9778
Universitatsspital-Basel, Basel, CH-4031, Switzerland; Recruiting
Alois Gratwohl, MD 41-61-265-4277 hematology@uhbs.ch
Basel, CH 4051, Switzerland; Recruiting
Walter Weber-Stadelmann, MD 41-61-261-0225 cancer@bluewin.ch
Study chairs or principal investigators
Ruediger Hehlmann, MD, Study Chair, III. Medizinische Klinik Mannheim
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
Study ID Numbers: CDR0000068957; III-MK-CML-3A; EU-20118; NCT00025402
Record last reviewed: September 2003
Last Updated: April 4, 2005
Record first received: October 11, 2001
ClinicalTrials.gov Identifier: NCT00025402
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Record last reviewed: September 2003
Last Updated: April 4, 2005
Record first received: October 11, 2001
ClinicalTrials.gov Identifier: NCT00025402
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
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