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Levodopa |
Dopar; Larodopa |
Levodopa Systematic (IUPAC) name (S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid Identifiers CAS number 59-92-7 ATC code N04BA01 PubChem 6047 DrugBank APRD00055 Chemical data Formula C9H11NO4 Mol. weight 197.19 g/mol Pharmacokinetic data Bioavailability 30% Metabolism Aromatic-L-amino-acid decarboxylase Half life 0.75–1.5 hours Excretion renal 70–80% Therapeutic considerations Pregnancy cat. B3(AU) C(US) Legal status ℞ Prescription only ...
Wikipedia - [full article]
Levodopa Clinical Trials
- Levetiracetam Administration for the Management of Levodopa-Induced Dyskinesias in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00291733 - Active, not recruiting
Levodopa Induced Dyskinesia
- Improved Language Acquisition with Levodopa
ClinicalTrials.gov Identifier: NCT00103805 - Active, not recruiting
Healthy
- Efficacy and Safety of Stalevo® in Patients with Parkinson's Disease Requiring Initiation of Levodopa Therapy
ClinicalTrials.gov Identifier: NCT00099268 - Active, not recruiting
Parkinson's Disease
- Continuous Delivery of Levodopa in Patients With Advanced Idiopathic Parkinsons Disease - Cost-Benefit
ClinicalTrials.gov Identifier: NCT00272688 - Recruiting
Parkinson Disease
- Study of Efficacy, Safety and Tolerability of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Subjects
ClinicalTrials.gov Identifier: NCT00357994 - Not yet recruiting
Parkinson's Disease; Severe Motor Fluctuations; Dyskinesias
- Efficacy of Levodopa/Carbidopa/Entacapone vs. Levodopa/Carbidopa in Parkinson's Disease Patients With Early Wearing Off
ClinicalTrials.gov Identifier: NCT00391898 - Recruiting
Parkinson's Disease
- Comparison of IPX054, Immediate-Release Carbidopa-Levodopa, and Controlled-Release Carbidopa-Levodopa in Subjects With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00279825 - Recruiting
Idiopathic Parkinson's Disease
- Adherence of Stalevo, Entacapone and Levodopa
ClinicalTrials.gov Identifier: NCT00245700 - Active, not recruiting
Parkinson's Disease
- A Study to Evaluate Fixed Dose Carbidopa/Levodopa/Entacapone Vs. Immediate Release Carbidopa/Levodopa
ClinicalTrials.gov Identifier: NCT00134966 - Completed
Parkinson''s Disease
- Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00218075 - Active, not recruiting
Cocaine Abuse; Cocaine-Related Disorders
- A Multicenter Study to Evaluate the Safety and Tolerability of Rasagiline in Advanced Parkinson’s Disease Patients With Motor Fluctuations Treated With Levodopa/Carbidopa Therapy.
ClinicalTrials.gov Identifier: NCT00203177 - Active, not recruiting
Parkinson's Disease
- Study of KW-6002 (Istradefylline) in Parkinson's Disease in Patients With Motor Response Complications on Levodopa
ClinicalTrials.gov Identifier: NCT00203957 - Active, not recruiting
Parkinson's Disease
- Efficacy, Safety, and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00368108 - Active, not recruiting
Parkinson's Disease
- A Multicenter Study to Determine the Effectiveness, Tolerability and Safety Using Two Doses of Study Medication (Rasagiline Mesylate) in Early Parkinson’s Disease Patients Not Treated With Levodopa
ClinicalTrials.gov Identifier: NCT00203060 - Active, not recruiting
Parkinson's Disease
- Stalevo in Early Wearing-Off Patients
ClinicalTrials.gov Identifier: NCT00125567 - Active, not recruiting
Idiopathic Parkinson''s Disease
- Influence of Theta Burst Stimulation and Carbidopa-Levodopa on Motor Performance in Stroke Patients
ClinicalTrials.gov Identifier: NCT00366184 - Recruiting
Stroke
- Developing Objective Measures of Levodopa Induced Dyskinesia: (Study 1)
ClinicalTrials.gov Identifier: NCT00467597 - Recruiting
Parkinson Disease; Dyskinesia; Movement Disorders
- Botulinum Toxin Type A (BOTOX) in the Management of Levodopa-Induced Peak-Dose Dyskinesias in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00477802 - Recruiting
Parkinson Disease
- DAPHNE (Duodopa in Advanced Parkinson''s: Health Outcomes & Net Economic Impact).
ClinicalTrials.gov Identifier: NCT00141518 - Active, not recruiting
advanced idiopathic Parkinson''s disease
- Swiss Restless Legs Syndrome Trial (SRLS)
ClinicalTrials.gov Identifier: NCT00144209 - Active, not recruiting
Restless Legs Syndrome
- Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients with Dyslexia
ClinicalTrials.gov Identifier: NCT00111371 - Recruiting
Dyslexia
- Efficacy and Safety of Levetiracetam Versus Placebo on Levodopa-Induced Dyskinesias in Advanced Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00307450 - Recruiting
Parkinson's Disease
- Efficacy, Safety and Tolerability of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00360308 - Recruiting
Parkinson's Disease
- A Study of E2007 as an Adjunctive Therapy in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00360412 - Recruiting
Parkinson's Disease
- Evaluating Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00219284 - Recruiting
Parkinson's Disease
- Dose-Finding Safety Study of BIIB014 in Combination With Levodopa in Moderate to Late Stage Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00438607 - Recruiting
Parkinson's Disease
- A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
ClinicalTrials.gov Identifier: NCT00455507 - Recruiting
Parkinson's Disease
- A Study of E2007 in Levodopa Treated Parkinson's Disease Patients With Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00286897 - Recruiting
Parkinson's Disease
- PK, PD and Safety of Multiple Doses of V1512 Tablets in PD Patients Compared to Standard Levodopa/Carbidopa Oral Tablets
ClinicalTrials.gov Identifier: NCT00491998 - Recruiting
Parkinson's Disease
- Comparison of IPX054 and Immediate-Release Carbidopa-Levodopa in Patients With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00253084 - Recruiting
Parkinson's Disease
- Dopamine Turnover Rate as Surrogate Parameter for Diagnosis of Early Parkinson''s Disease
ClinicalTrials.gov Identifier: NCT00153972 - Recruiting
Parkinson''s Disease
- Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone Under Fasting Conditions in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00415844 - Completed
Healthy
- PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding
ClinicalTrials.gov Identifier: NCT00562198 - Not yet recruiting
Parkinson´s Disease
- Study to Compare the Effect of Treatment with Carbidopa/Levodopa/Entacapone on the Quality of Life of Patients with Parkinson''s Disease.
ClinicalTrials.gov Identifier: NCT00143026 - Completed
Parkinson''s Disease
- Timing of levodopa treatment in Parkinson's disease
ClinicalTrials.gov Identifier: NCT00004733 - Completed
Parkinson's Disease
- Dopaminergic Enhancement of Learning and Memory in Aphasia
ClinicalTrials.gov Identifier: NCT00102869 - Recruiting
Cerebrovascular Accident; Aphasia
- A Multicenter, Open-Label Trial to Assess Subject Preference of PARCOPA, Carbidopa/Levodopa Orally Disintegrating Tablets, Compared to Conventional Carbidopa/Levodopa Tablets in Subjects with Stable Parkinson''s Disease
ClinicalTrials.gov Identifier: NCT00139867 - Completed
Parkinson''s Disease
- Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00415740 - Completed
Healthy
- Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00415831 - Completed
Healthy
- Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00415922 - Completed
Healthy
- Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects
ClinicalTrials.gov Identifier: NCT00360568 - Not yet recruiting
Parkinson's Disease; Severe Motor Fluctuations; Dyskinesia
- Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced PD
ClinicalTrials.gov Identifier: NCT00335153 - Not yet recruiting
Advanced Parkinson's Disease With Severe Motor Fluctuations; Dyskinesia
- The Effect Of E2007 On Pharmacodynamic Responses To Levodopa Among Patients With Parkinson's Disease Who Experience Dyskinesia And Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00451633 - Not yet recruiting
Parkinson's Disease
- Evaluation of the Long-Term Safety, Tolerability, and Efficacy of Perampanel (E2007) as an Adjunctive Therapy in Levodopa Treated Parkinson's Disease Subjects With Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00505622 - Not yet recruiting
Parkinson's Disease
- AMPA Receptor Antagonist Treatment of Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00108667 - Completed
- A Multiple-Dose Study of Sinemet® CR (Carbidopa/Levodopa) in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00460954 - Completed
Parkinson's Disease
- Comtess® Versus Cabaseril® as Add-on to Levodopa in the Treatment of Parkinsonian Patients Suffering From Wearing- Off.
ClinicalTrials.gov Identifier: NCT00247247 - Completed
Parkinson's Disease
- Study of the Modification of the Pharmacokinetic Profile of Levodopa by the Fiber Plantago Ovata Husk
ClinicalTrials.gov Identifier: NCT00507715 - Completed
Parkinson's Disease, Idiopathic
- A Study of Istradefylline (KW-6002) for the Treatment of Parkinson’s Disease in Patients Taking Levodopa
ClinicalTrials.gov Identifier: NCT00199407 - Completed
Parkinson's Disease
- Rotigotine Patch in Subjects With Advanced Stage, Idiopathic Parkinson’s Disease Who Are Not Well Controlled on Levodopa
ClinicalTrials.gov Identifier: NCT00244387 - Completed
Parkinson Disease, Idiopathic
- A Study of Istradefylline (KW-6002) for the Treatment of Parkinson’s Disease in Patients Taking Levodopa
ClinicalTrials.gov Identifier: NCT00199355 - Completed
Parkinson’s Disease
- ACP-103 to Treat Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00086294 - Completed
- A Study of Istradefylline (KW-6002) in Treating Patients With Parkinson’s Disease on Levodopa
ClinicalTrials.gov Identifier: NCT00199420 - Completed
Parkinson’s Disease
- A Multicenter Study to Assess the Effectiveness, Tolerability, and Safety of the Study Medication, Rasagiline, in Parkinson’s Disease Patients Using Levodopa and Experiencing Motor Fluctuations
ClinicalTrials.gov Identifier: NCT00203034 - Completed
Parkinson's Disease
- 12-Week, Double-Blind, Placeob-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa
ClinicalTrials.gov Identifier: NCT00456794 - Completed
Parkinson's Disease
- 12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa
ClinicalTrials.gov Identifier: NCT00456586 - Completed
Parkinson's Disease
- Levetiracetam Treatment of L-dopa Induced Dyskinesias
ClinicalTrials.gov Identifier: NCT00076674 - Completed
Dyskinesias; Parkinson Disease
- Intravenous Levodopa for the Diagnosis of Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00001928 - Completed
Parkinson Disease
- Riluzole to Treat Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00013624 - Completed
Parkinson's Disease
- Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00006077 - Completed
Parkinson's Disease
- Study of the Effects of Dopaminergic Medications on Dopamine Transporter Density in Subjects with Parkinson''s Disease
ClinicalTrials.gov Identifier: NCT00129181 - Completed
Parkinson Disease; Parkinsonian Syndrome
- Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy
ClinicalTrials.gov Identifier: NCT00432393 - Completed
Nonarteritic Anterior Ischemic Optic Neuropathy
- Lisuride Patch to Treat Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00089622 - Completed
Parkinson Disease
- Study of the Effects of Dopaminergic Medications on Dopamine Transporter Imaging in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00096720 - Completed
Parkinson Disease; Parkinsonian Syndrome
- JP-1730 to Treat Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00040209 - Completed
Parkinson Disease
- EMD 128130 for the Treatment of Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00009048 - Completed
Parkinson's Disease
- KW-6002 to Treat Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00006337 - Completed
Parkinson's Disease
- A Randomized, Double-Blind, Placebo-Controlled, Five Parallel Groups Efficacy and Safety Study of NS 2330 (Tesofensine) (0.125 Mg, 0.25 Mg, 0.5 Mg and 1.0 Mg) Administered Orally Once Daily Over 14 Weeks in Levodopa Treated Parkinson Patients with Motor F
ClinicalTrials.gov Identifier: NCT00148512 - Completed
Parkinson Disease
- Neuromodulation and Language Acquisition (Project stage Ia)
ClinicalTrials.gov Identifier: NCT00102284 - Terminated
Healthy
- Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00296959 - Terminated
Parkinson's Disease
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