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Dapsone |
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Dapsone Systematic (IUPAC) name 4,4'sulfonyldianiline Identifiers CAS number 80-08-0 ATC code J04BA02 PubChem 2955 DrugBank APRD00345 Chemical data Formula C12H12N2O2S Mol. weight 248.302 g/mol Pharmacokinetic data Bioavailability 70 to 80% Protein binding 70 to 90% Metabolism Hepatic (mostly CYP2E1-mediated) Half life 20 to 30 hours Excretion Renal Therapeutic considerations Pregnancy cat. B2 (Au), C (U.S.) Legal status ℞-only (U.S.), ...
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Dapsone Clinical Trials
- A Phase 3 Study to Compare the Safety and Efficacy of 5% Dapsone Topical Gel, (DTG) Twice Daily in Combination with Once Daily Vehicle Control, Adapalene Gel 0.1% or Benzoyl Peroxide Gel 4%.
ClinicalTrials.gov Identifier: NCT00151541 - Completed
Acne Vulgaris
- Chlorproguanil-Dapsone-Artesunate (CDA) Versus Chlorproguanil-Dapsone (LAPDAP) For Uncomplicated Malaria
ClinicalTrials.gov Identifier: NCT00371735 - Completed
Malaria
- Intermittent Preventive Treatment with Antimalarials in Kenyan Infants
ClinicalTrials.gov Identifier: NCT00111163 - Active, not recruiting
Malaria; Anemia
- A Randomised Trial of Antimalarial Drugs Used in Pregnancy in Tanzania
ClinicalTrials.gov Identifier: NCT00146731 - Active, not recruiting
Malaria; Pregnancy
- IPT and Efficacy of Sulphadoxine/Pyrimethamine and Chlorproguanil/Dapsone in 6-59 Month Old Children With Malaria.
ClinicalTrials.gov Identifier: NCT00361114 - Recruiting
Malaria
- Kilimanjaro IPTi Drug Options Trial
ClinicalTrials.gov Identifier: NCT00158574 - Recruiting
Malaria
- Chlorproguanil/Dapsone Compared with Chloroquine and SP for Vivax Malaria
ClinicalTrials.gov Identifier: NCT00158561 - Completed
Malaria; Vivax Malaria
- Dapsone 100 mg Versus 50 as Primary Prophylaxis for Pneumocystis carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
ClinicalTrials.gov Identifier: NCT00002043 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- Chlorproguanil-Dapsone in Pregnant Women
ClinicalTrials.gov Identifier: NCT00126971 - Suspended
Malaria
- A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides
ClinicalTrials.gov Identifier: NCT00000802 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis carinii Pneumonia in Pediatric HIV Infection
ClinicalTrials.gov Identifier: NCT00000739 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- Kidney Transplants in People with HIV Infection
ClinicalTrials.gov Identifier: NCT00023478 - Active, not recruiting
HIV Infections; End-Stage Renal Disease
- A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis carinii Pneumonia (PCP) in Patients with AIDS
ClinicalTrials.gov Identifier: NCT00002283 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS
ClinicalTrials.gov Identifier: NCT00000640 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites
ClinicalTrials.gov Identifier: NCT00000826 - Completed
Bacterial Infections; Mycoses; HIV Infections
- Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis carinii Pneumonia
ClinicalTrials.gov Identifier: NCT00002120 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- Chlorproguanil-Dapsone-Artesunate Versus COARTEM For Uncomplicated Malaria
ClinicalTrials.gov Identifier: NCT00344006 - Completed
Malaria
- A Phase II, Randomized Study of ACZONE™ (Dapsone) Gel, 5% for Papulopustular Rosacea.
ClinicalTrials.gov Identifier: NCT00249782 - Completed
Rosacea
- A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides
ClinicalTrials.gov Identifier: NCT00001028 - Terminated
Pneumonia, Pneumocystis carinii; HIV Infections
- Lapdap and Coartemether for Uncomplicated Malaria
ClinicalTrials.gov Identifier: NCT00118794 - Completed
Malaria
- Diffuse Fibrotic Lung Disease
ClinicalTrials.gov Identifier: NCT00000596 - Completed
Lung Diseases; Pulmonary Fibrosis; Sarcoidosis
- A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00000991 - Completed
Pneumonia, Pneumocystis carinii; HIV Infections
- A Phase II Study of ACZONE™ (Dapsone) Gel, 5% As a Treatment For Tarceva® (Erlotinib)Related Rash
ClinicalTrials.gov Identifier: NCT00343187 - Terminated
Rash; Non-Small-Cell Lung Cancer
- Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris
ClinicalTrials.gov Identifier: NCT00429533 - Terminated
Pemphigus Vulgaris
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