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Dacarbazine |
DTIC; DTIC-Dome |
Dacarbazine Systematic (IUPAC) name 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide Identifiers CAS number 4342-03-4 ATC code L01AX04 PubChem 2942 DrugBank APRD00331 Chemical data Formula C6H10N6O Mol. weight 182.18 Pharmacokinetic data Bioavailability ? Metabolism ? Half life 5 hours Excretion 40% renal (unchanged) Therapeutic considerations Pregnancy cat. C Legal status ℞ Prescription only Routes IV Dacarbazine (da-KAR-ba ...
Wikipedia - [full article]
Dacarbazine Clinical Trials
- Dacarbazine and Ipilimumab vs. Dacarbazine With Placebo in Untreated Unresectable Stage III or IV Melanoma
ClinicalTrials.gov Identifier: NCT00324155 - Recruiting
Melanoma
- Temozolomide Versus Dacarbazine in Stage IV Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00091572 - Active, not recruiting
Melanoma
- Thalidomide and Dacarbazine for Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00006200 - Active, not recruiting
Melanoma
- Oblimersen and Dacarbazine in Treating Patients With Advanced Malignant Melanoma That Has Responded to Treatment on Clinical Trial GENTA-GM301
ClinicalTrials.gov Identifier: NCT00070343 - Active, not recruiting
Stage IV Melanoma; stage III melanoma
- Trial of PI-88 with Dacarbazine in Patients with Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00130442 - Recruiting
Melanoma
- Dacarbazine With or Without Oblimersen (G3139) in Treating Patients With Advanced Malignant Melanoma
ClinicalTrials.gov Identifier: NCT00016263 - Active, not recruiting
stage III melanoma; Stage IV Melanoma; Recurrent Melanoma
- Temozolomide or Dacarbazine in Treating Patients With Stage IV Melanoma
ClinicalTrials.gov Identifier: NCT00101218 - Active, not recruiting
Recurrent Melanoma; Stage IV Melanoma
- PI-88 and/or Dacarbazine in Treating Patients With Metastatic Melanoma That Cannot Be Removed By Surgery
ClinicalTrials.gov Identifier: NCT00128648 - Recruiting
Recurrent Melanoma; Stage IV Melanoma
- Chemotherapy With or Without Immunotherapy in Treating Patients With Stage III or Stage IV Melanoma
ClinicalTrials.gov Identifier: NCT00003647 - Active, not recruiting
Stage IV Melanoma; stage III melanoma; Recurrent Melanoma
- Imatinib in Combination With Dacarbazine and Capecitabine in Medullary Thyroid Carcinoma
ClinicalTrials.gov Identifier: NCT00354523 - Active, not recruiting
Solid Tumor; Thyroid Cancer
- Lenalidomide and Dacarbazine (DTIC) in Patients With Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00412581 - Active, not recruiting
Melanoma
- A Phase I/II Study of Sunitinib and Dacarbazine
ClinicalTrials.gov Identifier: NCT00496223 - Recruiting
Melanoma
- Volociximab and Dacarbazine in Treating Patients With Unresectable Stage III or Stage IV Melanoma
ClinicalTrials.gov Identifier: NCT00109915 - Recruiting
Recurrent Melanoma; stage III melanoma; Stage IV Melanoma
- A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of PARP in Combination With Dacarbazine
ClinicalTrials.gov Identifier: NCT00516802 - Recruiting
Melanoma Neoplasms
- A Phase II, Multi-Center, Open-Label, Uncontrolled Study to Evaluate the Efficacy and Safety of Sorafenib Given Daily in Combination With Repeated 21-Day Cycles of Dacarbazine (DTIC) Chemotherapy in Subjects With Advanced Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00492297 - Active, not recruiting
Cancer; Melanoma
- Phase 3 Trial of Ticilimumab Versus Either Dacarbazine or Temozolomide in Patients Without Prior Therapy
ClinicalTrials.gov Identifier: NCT00257205 - Active, not recruiting
Melanoma
- Study of Taxoprexin Injection vs. Dacarbazine in Patients with Metastatic Malignant Melanoma
ClinicalTrials.gov Identifier: NCT00087776 - Active, not recruiting
Malignant Melanoma
- Preoperative Thalidomide With Radiation Therapy for Patients With Low-Grade Primary Soft Tissue Sarcoma or Thalidomide With Radiation Therapy, Doxorubicin, Ifosfamide, and Dacarbazine for Patients with High or Intermediate Grade Primary Soft Tissue Sarcom
ClinicalTrials.gov Identifier: NCT00089544 - Active, not recruiting
stage I adult soft tissue sarcoma; stage II adult soft tissue sarcoma; stage III adult soft tissue sarcoma; recurrent adult soft tissue sarcoma
- AGENDA : Randomized Trial of Dacarbazine With or Without Genasense in Advanced Melanoma
ClinicalTrials.gov Identifier: NCT00518895 - Recruiting
Melanoma
- Phase I Safety Study Of The Combination Of Lenalidomide And DTIC (Dacarbazine) In Patients With Metastatic Malignant Melanoma Previously Untreated With Systemic Chemotherapy
ClinicalTrials.gov Identifier: NCT00179608 - Active, not recruiting
Malignant Melanoma
- Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-Risk Melanoma Patients
ClinicalTrials.gov Identifier: NCT00553618 - Recruiting
Metastatic Melanoma
- Bevacizumab, Dacarbazine and Interferon-Alfa to Treat Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00308607 - Recruiting
Metastatic Melanoma
- Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003389 - Active, not recruiting
adult Hodgkin's lymphoma
- Evaluating The Antitumor Activity Of MEDI-522 With Or Without Dacarbazine In Patients With Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00066196 - Active, not recruiting
Melanoma; Malignant Metastatic Melanoma
- Safety Study of IMC-1121B With or Without Dacarbazine to Treat Metastatic Malignant Melanoma
ClinicalTrials.gov Identifier: NCT00533702 - Recruiting
Metastatic Malignant Melanoma
- Combination Chemotherapy With or Without Interleukin-2 and Interferon alfa in Treating Patients With Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00003027 - Active, not recruiting
Stage IV Melanoma
- Therapy Based on Stage of Disease and Risk Assessment in Treating Children With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00002802 - Active, not recruiting
stage IVS neuroblastoma; disseminated neuroblastoma; localized unresectable neuroblastoma; regional neuroblastoma; localized resectable neuroblastoma
- Interferon alfa With or Without Combination Chemotherapy Plus Interleukin-2 in Treating Patients With Melanoma
ClinicalTrials.gov Identifier: NCT00002882 - Active, not recruiting
stage III melanoma
- Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Men With Stage III or Stage IV Hodgkin's Disease
ClinicalTrials.gov Identifier: NCT00005090 - Active, not recruiting
adult Hodgkin's disease
- Safety Study of Dacarbazine and Bortezomib in Melanoma and Soft Tissue Sarcoma
ClinicalTrials.gov Identifier: NCT00580320 - Recruiting
Melanoma; Soft Tissue Sarcoma; Parathyroid Carcinoma; Small Cell Carcinoma of the Lung; Carcinoid Tumors
- Combination Chemotherapy, Interferon alfa, and Interleukin-2 in Treating Patients With Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00002669 - Active, not recruiting
Stage IV Melanoma; Recurrent Melanoma
- Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00041210 - Recruiting
adult Hodgkin's lymphoma
- Combination Chemotherapy Plus Biological Therapy in Treating Patients With Metastatic Melanoma
ClinicalTrials.gov Identifier: NCT00004141 - Active, not recruiting
stage III melanoma; Stage IV Melanoma; Recurrent Melanoma
- Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease
ClinicalTrials.gov Identifier: NCT00003421 - Active, not recruiting
stage II adult Hodgkin's disease; stage III adult Hodgkin's disease; stage IV adult Hodgkin's disease; stage I adult Hodgkin's disease
- Combination Chemotherapy and Radiation Therapy in Treating Children With Previously Untreated Stage II, Stage III, or Stage IV Hodgkin's Disease
ClinicalTrials.gov Identifier: NCT00004010 - Active, not recruiting
stage III childhood Hodgkin's disease; stage IV childhood Hodgkin's disease; childhood lymphocyte predominant Hodgkin's disease; ...
- Radiation Therapy and Chemotherapy in Treating Patients With Hodgkin's Disease
ClinicalTrials.gov Identifier: NCT00002561 - Active, not recruiting
adult lymphocyte predominant Hodgkin's disease; adult lymphocyte depletion Hodgkin's disease; adult mixed cellularity Hodgkin's disease; ...
- Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplantation in Treating Children With Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00025064 - Active, not recruiting
stage II childhood Hodgkin's lymphoma; stage I childhood Hodgkin's lymphoma; stage III childhood Hodgkin's lymphoma; ...
- Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00017225 - Active, not recruiting
localized resectable neuroblastoma; regional neuroblastoma; disseminated neuroblastoma; stage 4S neuroblastoma; recurrent neuroblastoma; ...
- Chemotherapy Plus Biological Therapy in Treating Patients With Melanoma
ClinicalTrials.gov Identifier: NCT00006237 - Recruiting
stage III melanoma; Recurrent Melanoma
- Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Stage III or Stage IV Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00049595 - Recruiting
adult lymphocyte depletion Hodgkin's lymphoma; adult mixed cellularity Hodgkin's lymphoma; adult nodular sclerosis Hodgkin's lymphoma; ...
- Dacarbazine and/or Cisplatin Compared With Complete Metastasectomy in Treating Patients With Stage IV Melanoma
ClinicalTrials.gov Identifier: NCT00072124 - Completed
Melanoma (Skin)
- Volociximab in Combination with DTIC in Patients with Metastatic Melanoma Not Previously Treated with Chemotherapy
ClinicalTrials.gov Identifier: NCT00099970 - Completed
Melanoma; Metastases
- Phase II Study of Filgrastim (G-CSF) Plus ABVD in the Treatment of HIV-Associated Hodgkin's Disease
ClinicalTrials.gov Identifier: NCT00000626 - Completed
HIV Infections; Hodgkin's Disease
- Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus
ClinicalTrials.gov Identifier: NCT00033644 - Completed
stage IV uterine sarcoma; recurrent uterine sarcoma; uterine leiomyosarcoma
- Chemotherapy Plus Radiation Therapy Followed by Surgery in Treating Patients With Soft Tissue Sarcoma
ClinicalTrials.gov Identifier: NCT00002791 - Completed
recurrent adult soft tissue sarcoma; stage II adult soft tissue sarcoma; stage III adult soft tissue sarcoma
- Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma
ClinicalTrials.gov Identifier: NCT00023738 - Completed
stage IIC adult soft tissue sarcoma; recurrent adult soft tissue sarcoma; stage III adult soft tissue sarcoma
Resources
- Dacarbazine (Drug Digest)
- DTIC (Drug Digest)
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