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Rosuvastatin |
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Rosuvastatin Systematic (IUPAC) name 7-[4-(4-fluorophenyl) -6-(1-methylethyl)- 2-(methyl-methylsulfonyl-amino)- pyrimidin- 5-yl]- 3,5-dihydroxy-hept-6-enoic acid Identifiers CAS number 287714-41-4 ATC code C10AA07 PubChem 6439133 DrugBank APRD00546 Chemical data Formula C22H28N3FO6S Mol. weight 481.539 Pharmacokinetic data Bioavailability 20% Metabolism Liver Half life 19 hours Excretion Urine / Faeces Therapeutic considerations Pregnancy ca ...
Wikipedia - [full article]
Rosuvastatin Clinical Trials
- Rosuvastatin Versus Pravastatin in HIV Patients Treated with Boosted Protease Inhibitors (PI)
ClinicalTrials.gov Identifier: NCT00117494 - Active, not recruiting
Hyperlipidemia; HIV Infections
- PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatin
ClinicalTrials.gov Identifier: NCT00355615 - Active, not recruiting
Familial Hypercholesterolemia
- The Effect of Rosuvastatin on Aortic Stiffness in Hemodialysis Patients in the AURORA Study
ClinicalTrials.gov Identifier: NCT00240279 - Active, not recruiting
Hypercholesterolemia
- Rosuvastatin in the Long-Term Treatment of Hypercholesterolaemic Subjects With Coronary Heart Disease
ClinicalTrials.gov Identifier: NCT00329160 - Active, not recruiting
Hypercholesteremia
- Exercise And Rosuvastatin Treatment: Is There an Anti-Inflammatory Synergy?
ClinicalTrials.gov Identifier: NCT00295373 - Active, not recruiting
Nonfamilial Hypercholesterolemia; Physical Inactivity
- Effect of TAK-475 or Placebo on Blood Cholesterol Levels in Subjects co-Administered Rosuvastatin
ClinicalTrials.gov Identifier: NCT00249912 - Active, not recruiting
Hyperlipidemia; Hypercholesterolemia
- GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF
ClinicalTrials.gov Identifier: NCT00336336 - Active, not recruiting
Heart Failure
- Pharmacokinetic (PK) Study of Single-Dose Rosuvastatin and Tipranavir/Ritonavir in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00344123 - Active, not recruiting
HIV Infections
- Study of Asian Patients With Hypercholesterolaemia in the UK - Rosuvastatin 5mg Versus Atorvastatin 10mg
ClinicalTrials.gov Identifier: NCT00427960 - Active, not recruiting
Hypercholesterolaemia
- Rosuvastatin and Renal Endothelial Function
ClinicalTrials.gov Identifier: NCT00160745 - Completed
Hypercholesterolemia
- Effect of Rosuvastatin on Left Ventricular Remodeling
ClinicalTrials.gov Identifier: NCT00505154 - Recruiting
Dilated Cardiomyopathy
- A Multicenter Study Comparing the Safety and Efficacy of ABT-335 and Rosuvastatin Calcium Combination Therapy to Monotherapy in Subjects With Mixed Dyslipidemia
ClinicalTrials.gov Identifier: NCT00300482 - Active, not recruiting
Mixed Dyslipidemia
- A Study Investigating Blood Concentrations Of Rosuvastatin When Co-Administered With GW856553 In Healthy Men
ClinicalTrials.gov Identifier: NCT00549653 - Recruiting
Atherosclerosis
- Rosuvastatin Affecting Aortic Valve Endothelium
ClinicalTrials.gov Identifier: NCT00114491 - Completed
Atherosclerosis; Hypercholesterolemia
- LUNAR IIIb Study Comparing Rosuvastatin and Atorvastatin in Subjects With Acute Coronary Syndromes
ClinicalTrials.gov Identifier: NCT00214630 - Active, not recruiting
Acute Coronary Syndromes
- Dose Finding Trial of Rosuvastatin and Atorvastatin Versus Hepatitis C
ClinicalTrials.gov Identifier: NCT00446940 - Recruiting
Hepatitis C
- Real-Life EValuation Of High Dose RosUvastatin in High Risk Patients After TitraTION
ClinicalTrials.gov Identifier: NCT00526721 - Recruiting
Hypercholesterolemia
- Evaluate the Efficacy and Safety of Rosuvastatin Versus Simvastatin in Type 2 Diabetic Patients With Dyslipidemia
ClinicalTrials.gov Identifier: NCT00506961 - Recruiting
Diabetes Mellitus; Dyslipidemia
- 12-Week Open-Label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe
ClinicalTrials.gov Identifier: NCT00525824 - Recruiting
Hypercholesterolemia; Coronary Heart Disease; Atherosclerosis
- A Multicenter Study Comparing the Safety and Efficacy of ABT-335 and Rosuvastatin Calcium Combination Therapy to Monotherapy in Subjects With Dyslipidemia
ClinicalTrials.gov Identifier: NCT00463606 - Recruiting
Hypercholesterolemia; Dyslipidemia
- Effect of Rosuvastatin in Abdominal Sepsis
ClinicalTrials.gov Identifier: NCT00357123 - Recruiting
Sepsis
- Crestor RAPID (The Efficacy of RosuvAstatin for Korean Dyslipidemia PatIents With Diabetes)
ClinicalTrials.gov Identifier: NCT00526552 - Recruiting
Dyslipidemia; Diabetes
- Crestor RUSH (The Efficacy of RosUvaStatin for Korean Dyslipidemia Patients With Hypertension )
ClinicalTrials.gov Identifier: NCT00526708 - Recruiting
Dyslipidemia; Hypertension
- Dutch Sub Study: Controlled Rosuvastatin Multinational Study in Heart Failure (CORONA). PET Sub Study
ClinicalTrials.gov Identifier: NCT00228514 - Completed
Rosuvastatin; Heart Failure; Positron Emission Tomography (PET)
- Effect of Rosuvastatin on Triglyceride Levels in Mexican Hypertriglyceridemic Patients
ClinicalTrials.gov Identifier: NCT00473655 - Recruiting
Hypertriglyceridemia; Hyperlipoproteinemia Type IV; Hyperlipoproteinemia Type V; Hyperlipoproteinemia Type IIb; Hyperlipidemia
- Effect of Rosuvastatin on Amnesia and Orientation Through Galveston Outcome Amnesia Test in Moderate Head Injury
ClinicalTrials.gov Identifier: NCT00329758 - Recruiting
Head Injury
- Effect of Rosuvastatin in Intracerebral Hemorrhage
ClinicalTrials.gov Identifier: NCT00364559 - Recruiting
Intracerebral Hemorrhage; Stroke
- ROMEO (ROsuvastatin in MEtabolic Syndrome With Obesity)
ClinicalTrials.gov Identifier: NCT00395486 - Recruiting
Metabolic Syndrome X
- Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?
ClinicalTrials.gov Identifier: NCT00457652 - Recruiting
Ischemia Reperfusion Injury
- The Effect of Rosuvastatin on Adenosine Metabolism
ClinicalTrials.gov Identifier: NCT00554138 - Recruiting
Adenosine Metabolism
- Rosuvastatin for Hepatitis C
ClinicalTrials.gov Identifier: NCT00371579 - Not yet recruiting
Hepatitis C
- Rosuvastatin ORBITAL Germany
ClinicalTrials.gov Identifier: NCT00379249 - Completed
Hypercholesterolemia
- Interaction Between ABT-335, Rosuvastatin and Warfarin
ClinicalTrials.gov Identifier: NCT00487136 - Completed
Healthy
- Korean Rosuvastatin Effectiveness Study in Nondiabetic Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00335699 - Completed
Hypercholesterolemia
- Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy
ClinicalTrials.gov Identifier: NCT00239330 - Completed
Hypercholesteremia
- Rosuvastatin Impact on Ventricular Remodelling Lipids and Cytokines
ClinicalTrials.gov Identifier: NCT00240292 - Completed
Heart Failure, Congestive
- A Study Of SB-751689, Atorvastatin, Ketoconazole, And Rosuvastatin In Health Postmenopausal Women.
ClinicalTrials.gov Identifier: NCT00388596 - Completed
Osteoporosis
- Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET)
ClinicalTrials.gov Identifier: NCT00396110 - Completed
Hypercholesterolemia; Coronary Heart Disease
- PULSAR - A Prospective Study to Evaluate the Utility of Low Doses of the Statins Atorvastatin and Rosuvastatin.
ClinicalTrials.gov Identifier: NCT00329173 - Completed
Hypercholesterolaemia
- A Study Measuring Effects on Intima Media Thickness: An Evaluation of Rosuvastatin 40 Mg (METEOR)
ClinicalTrials.gov Identifier: NCT00225589 - Completed
Hypercholesteremia
- Pharmacokinetic Study of Rosuvastatin and Lopinavir/Ritonavir in HIV Patients
ClinicalTrials.gov Identifier: NCT00184951 - Completed
HIV Infections; Hyperlipidemia
- A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID)
ClinicalTrials.gov Identifier: NCT00240318 - Completed
Coronary Arteriosclerosis
- ORBITAL: Open-Label Primary Care Study: Rosuvastatin Based Compliance Initiatives Linked To Achievement Of LDL Goals
ClinicalTrials.gov Identifier: NCT00396240 - Completed
Primary Hypercholesterolaemia
- Rho Kinase in Patients with Atherosclerosis
ClinicalTrials.gov Identifier: NCT00115830 - Completed
Atherosclerosis
- Evaluation of the Efficacy of Rosuvastatin in Daily Practice in Untreated High Risk Patients (CHALLENGE)
ClinicalTrials.gov Identifier: NCT00574782 - Completed
Hypercholesterolemia; Coronary Heart Disease; Peripheral Vascular Disease; CVA; Diabetes
- Study of High Density Lipoprotein Cholesterol (HDL-C)-Raising Mechanism of Rosuvastatin (CRESTOR™) by Quantifying the Key Steps of Reverse Cholesterol Transport (RCT)
ClinicalTrials.gov Identifier: NCT00240266 - Completed
Metabolic Syndrome; Dyslipidemia
- A Study to Investigate the Effect of Rosuvastatin (CRESTOR®) on High Density Lipoprotein Kinetics in Patients With the Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00240305 - Completed
Metabolic Syndrome; Dyslipidemia
- Impact of Rosuvastatin on Endothelial Function and Inflammation in Patients With Chronic Heart Failure
ClinicalTrials.gov Identifier: NCT00176332 - Completed
Heart Failure
- Rosuvastatin and Ischemia Reperfusion
ClinicalTrials.gov Identifier: NCT00315510 - Completed
Ischemia
- Assessment of the Lipid Lowering Effect of Rosuvastatin Compared to Atorvastatin in Subjects With Coronary Heart Disease
ClinicalTrials.gov Identifier: NCT00235950 - Completed
Coronary Heart Disease
- Effects in The ApoB/ApoA-I Ratio Using Rosuvastatin and Atorvastatin in Patients With Acute Coronary Syndrome
ClinicalTrials.gov Identifier: NCT00296387 - Completed
Acute Coronary Syndrome
- DIALOOG: Crestor in Patients With Diabetes Mellitus Type 2: Lowering of LDL-C Levels to New European Guidelines
ClinicalTrials.gov Identifier: NCT00233649 - Completed
Diabetes Mellitus Type 2; Crestor, Rosuvastatin; LDL Cholesterol; Observational
- Comparative Efficacy Evaluation of Lipids when Treated with Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
ClinicalTrials.gov Identifier: NCT00079638 - Completed
Dyslipidemia; Coronary Heart Disease; Atherosclerosis; Stroke; Diabetes
Resources
- Crestor (Drug Digest)
- Crestor Consumer Information (U.S. Food and Drug Administration)
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