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Clobetasol propionate - Article


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Clobetasol

Cormax; Embeline; Embeline E; Olux; Temovate 




Article: Clobetasol propionate

Image:Clobetasol propionate.png
Clobetasol propionate
Systematic (IUPAC) name
[17-(2-chloroacetyl)- 9-fluoro-11-hydroxy-10,13,16-trimethyl- 3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Identifiers
CAS number 25122-46-7
ATC code D07AD01
PubChem 32798
DrugBank APRD00876
Chemical data
Formula C25H32ClFO5
Mol. weight 466.97 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Clobetasol propionate comes in ointment and emollient cream presentations. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.

It is used to treat illnesses such as psoriasis, where it is used for the treatment of scalp and body psoriasis. This product usually works very well.

Presentations

  • Clobetasol propionate ointment USP 0.05%, supplied in 15 g, 30 g, and 45 g tubes.
  • Temovate & emollient 0.05%, supplied in 15 g (NDC 0173-0454-01), 30 g (NDC 0173-0454-02) and 60 g (NDC 0173-0454-03) tubes.
  • Clobetasol propionate foam 0.05% (Olux®)

Possible side effects

  • Acneform eruptions
  • Allergic contact dermatitis
  • Burning sensation
  • Cracking and fissuring of the skin
  • Cushing's syndrome
  • Dryness
  • Erythema
  • Folliculitis
  • Hypertrichosis
  • Hypopigmentation
  • Itching
  • Irritation
  • Millaria
  • Numbness of fingers
  • Perioral dermatitis
  • Pruritus
  • Secondary infection
  • Skin atrophy
  • Skin maceration
  • Stinging
  • Striae
  • Telangiectasia
Retrieved from "http://en.wikipedia.org/wiki/Clobetasol_propionate"

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November 8, 2009



Page Updated: July 22, 2006
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