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Bupropion Sustained-Release (Zyban) |
Buproban; Zyban |
Bupropion Systematic (IUPAC) name (±)-1-(3-chlorophenyl)- 2-[(1,1-dimethylethyl)amino]- 1-propanone Identifiers CAS number 34841-39-9 ATC code N07BA02 PubChem 444 DrugBank APRD00621 Chemical data Formula C13H18NClO Mol. weight 239.74 Pharmacokinetic data Bioavailability 5-20% in animals; no studies in humans Metabolism Hepatic Half life 20 hours Excretion Urine (87%), feces (10%) Therapeutic considerations Pregnancy cat. B (USA) Legal statu ...
Wikipedia - [full article]
Bupropion Sustained-Release (Zyban) Clinical Trials
- Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke
ClinicalTrials.gov Identifier: NCT00307203 - Active, not recruiting
Tobacco-Use Disorder; Schizophrenia; Psychotic Disorders
- Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 2: Do Varenicline (Chantix) and Bupropion (Zyban) Change Alcohol Drinking?
ClinicalTrials.gov Identifier: NCT00580645 - Recruiting
Alcohol Drinking
- The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior
ClinicalTrials.gov Identifier: NCT00580853 - Recruiting
Smoking Lapse Behavior
- Randomized Trial of Ultrashort Psychotherapy vs Sustained-Release Bupropion for Smoking Cessation
ClinicalTrials.gov Identifier: NCT00484692 - Completed
Nicotine Dependence; Substance Abuse; Substance Dependence; Tobacco Dependence
- A GCRC Study: A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine
ClinicalTrials.gov Identifier: NCT00314340 - Active, not recruiting
Chronic Pain
- Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation
ClinicalTrials.gov Identifier: NCT00419731 - Recruiting
Tobacco Use Disorder
- Comparison of 23 mg Donepezil Sustained Release (SR) to 10 mg Donepezil Immediate Release (IR) in Patients With Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00478205 - Recruiting
Alzheimer's Disease
- Pilot Study of Bupropion for Smoking Cessation in Postpartum Non-Breastfeeding Women
ClinicalTrials.gov Identifier: NCT00119210 - Active, not recruiting
Tobacco Use Disorder
- Bupropion and Weight Control for Smoking Cessation - 1
ClinicalTrials.gov Identifier: NCT00006170 - Active, not recruiting
Tobacco Use Disorder
- Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal Women
ClinicalTrials.gov Identifier: NCT00406640 - Active, not recruiting
Depression; Depressive Disorder; Depressive Disorder, Major
- Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Vs Placebo in Peri- and Postmenopausal Women
ClinicalTrials.gov Identifier: NCT00369343 - Active, not recruiting
Depression; Depressive Disorder; Depressive Disorder, Major
- A Study of the Effectiveness and Safety of Sustained-Release Hydromorphone (a Strong Opioid) in Patients With Chronic Noncancer Pain.
ClinicalTrials.gov Identifier: NCT00261495 - Active, not recruiting
Pain
- Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
ClinicalTrials.gov Identifier: NCT00418691 - Recruiting
Brain Tumor
- Framing Messages for Smoking Cessation with Bupropion - 6
ClinicalTrials.gov Identifier: NCT00104598 - Active, not recruiting
Tobacco Use Disorder
- Bupropion as a Smoking Cessation Aid in Alcoholics
ClinicalTrials.gov Identifier: NCT00044434 - Active, not recruiting
Alcoholism; Smoking
- Assessment of Potential Interactions between Methamphetamine and Bupropion - 1
ClinicalTrials.gov Identifier: NCT00040040 - Active, not recruiting
Amphetamine-Related Disorders
- Bupropion for the Treatment of Methamphetamine Dependence - 1
ClinicalTrials.gov Identifier: NCT00069251 - Active, not recruiting
Amphetamine-Related Disorders
- Effectiveness of Bupropion Combined with Behavioral Thearpy for Treating Methamphetamine Dependence - 2
ClinicalTrials.gov Identifier: NCT00135785 - Recruiting
methamphetamine
- Effect of Sustained-Release Cetylpyridinium Chloride Varnish on Streptococcus Mutans and Lactobacillus in Orthodontic Patients
ClinicalTrials.gov Identifier: NCT00416286 - Not yet recruiting
Healthy
- Effects of a Voucher Incentive Program and a Pharmacological Intervention (Bupropion) on Smoking in People with Schizophrenia. - 1
ClinicalTrials.gov Identifier: NCT00136760 - Recruiting
Tobacco Use Disorder
- Effectiveness of Bupropion in Treating Marijuana Dependent Individuals - 1
ClinicalTrials.gov Identifier: NCT00142870 - Active, not recruiting
Marijuana Abuse; Substance-Related Disorders
- Effectiveness of Bupropion for Treating Nicotine Dependence in Young People - 1
ClinicalTrials.gov Identifier: NCT00129272 - Recruiting
Tobacco Use Cessation; Tobacco Use Disorder
- Use of Sustained Release Antiepileptic Medication (Depakote® ER) for Pediatric Epilepsy in a Mental Retardation/Developmental Disorder Population
ClinicalTrials.gov Identifier: NCT00207935 - Recruiting
Epilepsy; Mental Retardation; Developmental Disabilities
- Effects of Sustained Release d-Amphetamine and Buprenorphine on Drug Seeking Behavior in Opioid and Cocaine Dependent Individuals Who Are Not Seeking Treatment
ClinicalTrials.gov Identifier: NCT00429767 - Recruiting
Heroin Dependence; Opioid-Related Disorders; Cocaine Abuse or Dependence
- Bupropion and Counseling With or Without Contingency Management to Enhance Smoking Cessation in Treating Cancer Survivors Who Continue to Smoke
ClinicalTrials.gov Identifier: NCT00079469 - Active, not recruiting
unspecified adult solid tumor, protocol specific
- Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
ClinicalTrials.gov Identifier: NCT00511134 - Recruiting
Insomnia; Nicotine Dependence
- Smoking Cessation Treatment - 1
ClinicalTrials.gov Identifier: NCT00110825 - Active, not recruiting
Behavior Therapy; Bupropion; Tobacco Use Disorder; nicotine transdermal system
- A Comparison of Bupropion SR and Placebo for Smoking Cessation
ClinicalTrials.gov Identifier: NCT00176449 - Active, not recruiting
Tobacco Use Disorder
- RLS In Adults: Comparing Immediate Release Formulation With Extended Release Formulation Of Ropinirole
ClinicalTrials.gov Identifier: NCT00314860 - Active, not recruiting
Restless Legs Syndrome
- Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals
ClinicalTrials.gov Identifier: NCT00308763 - Active, not recruiting
Tobacco Use Disorder
- Study Evalutating the Pharmacokinetics (PK) and Safety of a Single Dose of Desvenlafaxine Sustained Release (DVS SR)
ClinicalTrials.gov Identifier: NCT00440427 - Completed
Depressive Disorder, Major
- A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol(CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain
ClinicalTrials.gov Identifier: NCT00361504 - Active, not recruiting
Osteoarthritis; Sciatica; Pain Assessment; Arthralgia
- Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals
ClinicalTrials.gov Identifier: NCT00249509 - Active, not recruiting
Marijuana Abuse
- Risperidone Vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression
ClinicalTrials.gov Identifier: NCT00179244 - Active, not recruiting
Unipolar Depression
- Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
ClinicalTrials.gov Identifier: NCT00285584 - Active, not recruiting
HIV Infections; Depression
- A Study of Naltrexone SR/Bupropion SR and Placebo in Obese Subjects Participating in a Behavior Modification Program
ClinicalTrials.gov Identifier: NCT00456521 - Active, not recruiting
Obesity
- Bupropion for Hospital-Based Smoking Cessation
ClinicalTrials.gov Identifier: NCT00261170 - Active, not recruiting
Smoking
- Study Evaluating LAMICTAL Extended-release Therapy Added To Current Seizure Treatments In Patients With Partial Seizures
ClinicalTrials.gov Identifier: NCT00113165 - Active, not recruiting
Epilepsy
- Study of the Effectiveness and Tolerability of OROS Hydromorphone HCI SR(Slow-Release) Tablets and Immediate-Release Hydromorphone Tablets in Patients With Chronic Pain
ClinicalTrials.gov Identifier: NCT00410943 - Active, not recruiting
Pain
- Efficacy and Safety of Bupropion for Treatment of Adolescent Smoking
ClinicalTrials.gov Identifier: NCT00248118 - Recruiting
Tobacco Dependence
- Bupropion With Telephone-Based Counseling and/or Internet-Based Counseling in Helping Adults Stop Smoking
ClinicalTrials.gov Identifier: NCT00301145 - Active, not recruiting
Unspecified Adult Solid Tumor, Protocol Specific
- Drug Treatment for Pathological Gambling
ClinicalTrials.gov Identifier: NCT00055393 - Active, not recruiting
Gambling
- Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With Chronic Hepatitis C
ClinicalTrials.gov Identifier: NCT00207363 - Active, not recruiting
Hepatitis C
- Effect of Combined Pharmacotherapy/Behavioral Treatment on Smoking Cessation For Methadone Maintenance Therapy Patients - 2
ClinicalTrials.gov Identifier: NCT00060814 - Active, not recruiting
Tobacco Use Disorder
- Paroxetine Versus Bupropion for Treating People With High-Risk Major Depressive Disorder
ClinicalTrials.gov Identifier: NCT00429169 - Recruiting
Depression
- Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis
ClinicalTrials.gov Identifier: NCT00492622 - Recruiting
Gastroparesis; Gastroesophageal Reflux Disease
- Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in the Treatment of Major Depressive Disorders
ClinicalTrials.gov Identifier: NCT00326144 - Completed
Major Depressive Disorder
- Comparative Study of Modified Release (MR) Tacrolimus/MMF in de novo Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00064701 - Active, not recruiting
Kidney Transplantation
- Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism
ClinicalTrials.gov Identifier: NCT00330434 - Recruiting
Alcohol Drinking; Depression; Smoking Cessation; Attention Deficit Disorder
- Effectiveness of Bupropion Used in Combination with the Nicotine Replacement Patch and Cognitive Behavioral Therapy for Treating Nicotine Dependent Individuals - 1
ClinicalTrials.gov Identifier: NCT00142831 - Active, not recruiting
Tobacco Use Disorder
- Efficacy and Safety of Quetiapine Fumarate Sustained Release (SEROQUEL SR) in Combination With an Antidepressant in the Treatment of Major Depressive Disorders
ClinicalTrials.gov Identifier: NCT00326105 - Completed
Major Depressive Disorder
- ISTAPS: A Stepped Primary Care Smoking Cessation Intervention
ClinicalTrials.gov Identifier: NCT00125905 - Active, not recruiting
Smoking cessation
- Effect of Bupropion on Smoking Behavior in People With Schizophrenia Who Smoke
ClinicalTrials.gov Identifier: NCT00218231 - Recruiting
Schizophrenia
- A Study of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Obese Subjects
ClinicalTrials.gov Identifier: NCT00532779 - Recruiting
Obesity
- Dopamine Reuptake Inhibitors of Cocaine Abuse - 1
ClinicalTrials.gov Identifier: NCT00000276 - Active, not recruiting
Cocaine-Related Disorders
- Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00304707 - Recruiting
Smoking Cessation; Alcohol-Related Disorders
- Tobacco Dependence: Treatment and Outcomes Project 3 Pharmacotherapies: Effectiveness in Primary Care - 2
ClinicalTrials.gov Identifier: NCT00106873 - Recruiting
nicotine
- Bupropion in the Treatment of Methamphetamine Dependence
ClinicalTrials.gov Identifier: NCT00572234 - Recruiting
Methamphetamine Use Disorder
- A Randomised, Crossover Study Comparing the Biochemical and Platelet Effects of Modified-Release Dipyridamole/Aspirin (200mg/25 Mg Bd; Asasantin Retard®) with Aspirin (75 Mg Qd) in Coronary Artery Disease Patients with Aspirin Resistance Manifesting
ClinicalTrials.gov Identifier: NCT00129038 - Active, not recruiting
Coronary Arteriosclerosis
- Immediate Release (IR) to Sustained Release (SR) Switching Study: Study of Switching From IR Seroquel to SR Seroquel in Outpatients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00206128 - Completed
Schizophrenia
- A Study to Evaluate LAMICTAL Extended-release Therapy in Patients with Primary Generalized Tonic Clonic Seizures
ClinicalTrials.gov Identifier: NCT00104416 - Active, not recruiting
Tonic-Clonic Seizures; Epilepsy
- A Comparison of Ropinirole Immediate Release With Ropinirole Prolonged Release in Patients With Advanced Parkinson's
ClinicalTrials.gov Identifier: NCT00331149 - Recruiting
Parkinson's Disease
- Research Evaluating the Value of Augmenting Medication with Psychotherapy (REVAMP)
ClinicalTrials.gov Identifier: NCT00057551 - Active, not recruiting
Depression; Depressive Disorder
- A Within-Subject Cross-Over Comparison Between Immediate Release and Extended Release Adderall
ClinicalTrials.gov Identifier: NCT00468143 - Not yet recruiting
Attention Deficit Hyperactivity Disorder
- Study of a 6-Month Sustained-release Formulation of Leuprolide in Prostate Cancer
ClinicalTrials.gov Identifier: NCT00056654 - Completed
Prostatic Neoplasms
- Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults with Depression
ClinicalTrials.gov Identifier: NCT00106197 - Recruiting
Depression
- Acetaminophen-Induced Hepatotoxicity in Chronic Alcohol Abusers
ClinicalTrials.gov Identifier: NCT00137059 - Completed
hepatotoxicity
- A Study of Aripiprazole in Patients with Major Depressive Disorder
ClinicalTrials.gov Identifier: NCT00105196 - Active, not recruiting
Major Depressive Disorder
- Maintaining Abstinence in Chronic Cigarette Smokers - 1
ClinicalTrials.gov Identifier: NCT00087880 - Recruiting
Tobacco Use Disorder
- A Multicenter Trial to Investigate Fesoterodine Sustained Release in Overactive Bladder Syndrome
ClinicalTrials.gov Identifier: NCT00220363 - Completed
Overactive Bladder Syndrome
- A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Type 2 Diabetics
ClinicalTrials.gov Identifier: NCT00474630 - Recruiting
Obesity; Diabetes Mellitus, Type 2
- Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism
ClinicalTrials.gov Identifier: NCT00449007 - Recruiting
Depression; Alcoholism; Suicidal Behavior
- Maintenance Treatment for Abstinent Smokers - 1
ClinicalTrials.gov Identifier: NCT00063323 - Recruiting
Tobacco Use Disorder
- A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Obesity
ClinicalTrials.gov Identifier: NCT00567255 - Recruiting
Obesity
- Comparison of IPX054, Immediate-Release Carbidopa-Levodopa, and Controlled-Release Carbidopa-Levodopa in Subjects With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00279825 - Recruiting
Idiopathic Parkinson's Disease
- HRN 004- Peginterferon a-2a Plus Ribavirin for Chronic Hepatitis C Infection in HIV Infected Persons Who Have Failed to Achieve a Sustained Virologic Response Following Previous Interferon Therapy
ClinicalTrials.gov Identifier: NCT00215839 - Active, not recruiting
Chronic Hepatitis C Infection in HIV Infected Persons; HIV Infections
- A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent
ClinicalTrials.gov Identifier: NCT00563563 - Recruiting
Nicotine Dependence; Overweight; Obesity
- An Open Label, Single Arm, Extension Study to Evaluate the Long Term Safety and Sustained Efficacy of Denosumab (AMG162) in the Treatment of Postmenopausal Osteoporosis
ClinicalTrials.gov Identifier: NCT00523341 - Recruiting
Osteopenia; Osteoporosis
- Safety and Efficacy of Sustained Erythropoietin Therapy
ClinicalTrials.gov Identifier: NCT00542568 - Not yet recruiting
Anemia
- Tolerability of MK0524A Versus Niacin Extended-Release
ClinicalTrials.gov Identifier: NCT00378833 - Active, not recruiting
Hypercholesterolemia; Hyperlipidemia
- Effect of Food on Bioavailability of Modified Release Formulations of Imatinib
ClinicalTrials.gov Identifier: NCT00420043 - Active, not recruiting
Healthy
- Two Phase Extension Trial of SP668 to Investigate the Safety and Tolerability of Sustained Release Fesoterodine in Subjects With Overactive Bladder: a Double-Blind Phase Followed by an Open-Label Extension Phase
ClinicalTrials.gov Identifier: NCT00220389 - Completed
Overactive Bladder
- Bupropion in Helping Adults Stop Smoking
ClinicalTrials.gov Identifier: NCT00534001 - Recruiting
Bladder Cancer; Cervical Cancer; Esophageal Cancer; Gastric Cancer; Head and Neck Cancer; Kidney Cancer; Leukemia; Liver Cancer; Lung Cancer; Pancreatic Cancer; Tobacco Use Disorder
- Effect of an Investigational Compound on Tolerability of Extended Release Niacin
ClinicalTrials.gov Identifier: NCT00376584 - Active, not recruiting
Hypercholesteremia; Hyperlipidemia
- A Phase 3, Parallel Group, Randomized, Double-Blind, Placebo Controlled Multicenter Trial to Investigate the Efficacy, Tolerability and Safety of Fesoterodine Sustained Release in Subjects with Overactive Bladder Syndrome
ClinicalTrials.gov Identifier: NCT00138723 - Completed
Overactive Bladder
- Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1
ClinicalTrials.gov Identifier: NCT00124683 - Completed
Tobacco Use Cessation; Tobacco Use Disorder; Schizophrenia
- Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation
ClinicalTrials.gov Identifier: NCT00412100 - Active, not recruiting
Pain
- Testing the Effectiveness of Low-Dose Naltrexone Combined with Bupropion to Stop Smoking With Less Weight Gain
ClinicalTrials.gov Identifier: NCT00129246 - Completed
Smoking; Nicotine Dependence
- Study Evaluating Venlafaxine Extended Release in Elderly Depressed Patients
ClinicalTrials.gov Identifier: NCT00247429 - Active, not recruiting
Depressive Syndrome; Anxiety
- A Study To Look At The Starting Dose Of Ropinirole Immediate Release Tablets In Young Patients With Restless Legs Syndrome
ClinicalTrials.gov Identifier: NCT00140712 - Recruiting
Restless Legs Syndrome
- Safety and Quality of Life Study of Dexlansoprazole Modified Release Formulation to Treat Heartburn.
ClinicalTrials.gov Identifier: NCT00255190 - Active, not recruiting
Gastroesophageal Reflux Disease
- Safety and Tolerability of Long-Term Administration of Hydromorphone HCI CR (Controlled Release)
ClinicalTrials.gov Identifier: NCT00410748 - Active, not recruiting
Pain; Analgesics, Opioid
- To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With High Cholesterol.
ClinicalTrials.gov Identifier: NCT00271817 - Recruiting
Hypercholesterolemia
- ESP Study: A Study to Assess the Effect of Adding Fuzeon (Enfuvirtide) to an Antiretroviral Regimen in Fuzeon-Naive Patients With Sustained HIV Viral Suppression.
ClinicalTrials.gov Identifier: NCT00461266 - Recruiting
HIV Infections
- A Study of a Modified-Release Tacrolimus Based Immunosuppression Regimen in Stable Pediatric Liver Transplant Patients
ClinicalTrials.gov Identifier: NCT00282256 - Active, not recruiting
Liver Transplantation
- A Study to Assess the Pharmacokinetics of a Modified-Release Tacrolimus Based Immunosuppression Regimen in Stable Liver Transplant Patients
ClinicalTrials.gov Identifier: NCT00282243 - Active, not recruiting
Liver Transplantation
- A Study to Assess the Pharmacokinetics of a Modified-Release Tacrolimus Based Immunosuppression Regimen in Stable Kidney Transplant Patients
ClinicalTrials.gov Identifier: NCT00282568 - Active, not recruiting
Kidney Transplantation
- Onset Motor Complications Using REQUIP CR (Ropinirole Controlled-Release) As Add-on Therapy To L-Dopa In Parkinson's
ClinicalTrials.gov Identifier: NCT00363727 - Active, not recruiting
Parkinson's Disease; Dyskinesias
- An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)
ClinicalTrials.gov Identifier: NCT00399048 - Active, not recruiting
Osteoarthritis, Knee; Osteoarthritis, Hip
- Safety and Tolerability of Long-Term Administration of OROS Hydromorphone HCI (Slow Release) in Cancer Pain
ClinicalTrials.gov Identifier: NCT00410787 - Active, not recruiting
Pain; Analgesics, Opioid
Resources
- Bupropion Sustained-Release (Zyban) (Drug Digest)
- Zyban (Drug Digest)
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