Article: Brompheniramine

Brompheniramine
Systematic (IUPAC) name
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Identifiers
CAS number	86-22-6
ATC code	R06AB01
PubChem	6834
DrugBank	APRD00832
Chemical data
Formula	C16H19BrN2
Mol. weight	319.24
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	C (USA)
Legal status	Unscheduled, OTC
Routes	Oral

Brompheniramine (also known as Bromfed®, Bromfenex®, and Dimetane®) is an antihistamine drug of the propylamine class. It is commonly available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.

Pharmacology

Brompheniramine works by acting as an antagonist of histamine H1 receptors. It also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine.

Brompheniramine is metabolised via cytochrome P450 oxidase.

Side effects

Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.