Not Signed In -
Belladonna Alkaloids, Ergotamine, and Phenobarbital Tablets |
Bellacane SR; Bellaspas; Bellergal-S; Folergot-DF; Phenerbel-S; Spastrin |
Clinical Trial: Treatment of Hypertension
This study has been completed.
Purpose
To determine whether the long-term treatment of essential hypertension without significant target organ disease materially influenced mortality and/or cardiovascular renal morbidity.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Cardiovascular Diseases Heart Diseases Hypertension Vascular Diseases | Drug: chlorothiazide Drug: Rauwolfia alkaloids | Phase III |
MedlinePlus related topics: Heart Diseases; Heart Diseases--Prevention; High Blood Pressure; Vascular Diseases
Study Type: Interventional
Study Design: Prevention, Randomized, Double-Blind, Placebo Control
Study start: April 1966
BACKGROUND: This grant-supported, cooperative, fixed-protocol clinical study was initiated in 1966 and followed a cooperative study of the treatment of renal hypertension initiated in 1960 to evaluate the relative efficacy of several recognized drug regimens for reduction of blood pressure. Six centers (USPHS hospitals) and a coordinating center were involved in the trial.
DESIGN NARRATIVE: Randomized, double-blind, fixed sample. Three hundred and eighty nine eligible patients were assigned to drug therapy consisting of chlorothiazide plus Rauwolfia serpentina or to placebo.
Eligibility
Ages Eligible for Study: 21 Years - 55 Years, Genders Eligible for Study: Both
Criteria
Location Information
Anthony Damato, USPHS Hospital
Richard Thurm, USPHS Hospital
Christfried Urner, USPHS Hospital
John Vaillancourt, USPHS Hospital
J. Warbasse, USPHS Hospital
Robert Wells, USPHS Hospital
More Information
Publications
[No authors listed] Morbidity and mortality in mild essential hypertension. Circ Res. 1972 Sep;31(9):Suppl 2:110-24. No abstract available.
U.S. Public Health Service Hospitals Cooperative Study Group. Smith WM, et al: Intervention Trial in Mild Hypertension. Epidemiology and Control of Hypertension. Paul, O (Ed.), Symposia Specialists, Miami, l975, pp. 46l-483.
Elharrar V, Foster PR, Jirak TL, Gaum WE, Zipes DP. Alterations in canine myocardial excitability during ischemia. Circ Res. 1977 Jan;40(1):98-105.
Smith WM. Mild essential hypertension: benefit of treatment: discussion. Ann N Y Acad Sci. 1978 Mar 30;304:74-80. No abstract available.
Smith WM, Edlavitch SA, and Krushat WM: U.S. Public Health Service Hospitals Intervention Trial in Mild Hypertension. Hypertension, Determinants, Complications, and Intervention. Onesti G, and Klimt C, (Eds.), Grune & Stratton, New York, l979, pp. 38l-399.
Smith WM: Hypertension--Effectiveness of Early Treatment in Preventing Sequellae. Proceedings of the Eisenhower Medical Center. Preventive Interventions in the Practice of Medicine, Spring, l979, pp. 8l-87.
Smith WM, Edlavitch SA, and Krushat WM: Prevention of Stroke in Mild Hypertension: Public Health Service Hospitals Trial. Perspectives in Cardiovascular Research, Vol. 4. Prophylactic Approach to Hypertensive Diseases, Yamori Y, Lovenberg W, and Freis ED, (Eds.), Raven Press, New York, l979, pp. 53-62.
Record last reviewed: January 2000
Last Updated: October 13, 2004
Record first received: October 27, 1999
ClinicalTrials.gov Identifier: NCT00000484
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Bellacane SR (Drug Digest)
- Belladonna Alkaloids; Ergotamine; and Phenobarbital Tablets (Drug Digest)
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