Article: Atazanavir

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Atazanavir
Systematic (IUPAC) name
methyl N-[(1S)-1-[[[(2S,3S)-2-
hydroxy-3-[[(2S)-2-
(methoxycarbonylamino)-3,3-
dimethyl-butanoyl]amino]-4-phenyl-
butyl]-[(4-pyridin-2-ylphenyl)
methyl]amino]carbamoyl]-
2,2-dimethyl-propyl]carbamate
Identifiers
CAS number 198904-31-3
ATC code J05AE08
PubChem 148192
DrugBank APRD00804
Chemical data
Formula C38H52N6O7
Mol. weight 704.856 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

Atazanavir, trade name Reyataz®, (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).

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Two Reyataz 200mg capsules

Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications.

The Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. Atazanavir is the first PI approved for once-daily dosing, and also appears to be less likely to cause lipodystrophy and elevated cholesterol as side effects. It may also not be cross-resistant with other PIs. When boosted with ritonavir it is of equivalent potency to lopinavir for use in salvage therapy in patients with a degree of drug resistance.


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