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The Renin-Angiotensin System in Essential Hypertension - Article


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Candesartan

Atacand; candesartan cilexetil 



Clinical Trial: The Renin-Angiotensin System in Essential Hypertension

This study is currently recruiting patients.
Verified by St George''''s, University of London August 2005

Sponsored by: St George''''s, University of London
Information provided by: St George''''s, University of London
ClinicalTrials.gov Identifier: NCT00141583

Purpose

Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.
Condition Intervention
Hypertension
  Drug: Enalapril 20 mg bd
 Drug: Candesartan 8 mg bd

MedlinePlus related topics:  High Blood Pressure

Study Type: Interventional
Study Design: Educational/Counseling/Training, Randomized, Open Label, Active Control, Crossover Assignment

Further Study Details: 
Primary Outcomes: Change in BP; Change in PRA and aldosterone
Expected Total Enrollment:  11

Study start: April 2004;  Expected completion: October 2006

Eligibility

Ages Eligible for Study:  18 Years   -   70 Years,  Genders Eligible for Study:  Both
Criteria

Inclusion Criteria:

  • Essential Hypertension
  • SBP 140-159 mmHg
  • DBP 90-99 mmHg

Exclusion Criteria:

  • Intolerance of or allergy to ACE Inhibitors or ARBS
  • Pregnant or Breastfeeding
  • Pre-menopausal women
  • Uncontrolled cardiac or renal failure
  • Diabetes mellitus

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00141583

Timothy WR Doulton, BSc MRCP      +44 208 725 3176  Ext. -    tdoulton@sgul.ac.uk

United Kingdom
      Blood Pressure Unit, Dept. Cardiac & Vascular Sciences, SGUL, London,  SW17 0RE,  United Kingdom; Recruiting
Timothy WR Doulton, BSc MRCP  +44 208 725 3176  Ext. -    tdoulton@sgul.ac.uk 
Timothy WR Doulton, BSc MRCP,  Principal Investigator

Study chairs or principal investigators

Timothy WR Doulton, BSc MRCP,  Principal Investigator,  SGUL   

More Information

Study ID Numbers:  LREC 01.87.10
Last Updated:  August 31, 2005
Record first received:  August 31, 2005
ClinicalTrials.gov Identifier:  NCT00141583
Health Authority: United Kingdom: Research Ethics Committee
ClinicalTrials.gov processed this record on 2005-09-06


Source: ClinicalTrials.gov
Cache Date: September 7, 2005

Resources



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Page Updated: September 6, 2005
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