Trisenox is used to treat a form of leukemia (acute promyelocytic leukemia or APL) in adults who have not responded to other chemotherapy treatments, or in whom disease has returned after other chemotherapy.

Who should not be treated with Trisenox?

You should not be given Trisenox if you are allergic to arsenic.

Special Warning(s) with Trisenox:

Trisenox can cause changes in heart rhythms, which may cause symptoms, or in the worst case, could be fatal. The risk of these side effects may be increased if you:

• have a history of abnormal heart rhythms
• take other medications that affect the heart the same, such as:
  • erythromycin (antibiotic)
  • ketoconozole or amphotericin B (antifungals)
  • hydrochlorothiazide and furosemide (diuretics)
  • blood thinners
  • certain medicines to stabilize heart rhythms
  • thioridazine (mood and depression medicines)
• have congestive heart failure
• have other medical conditions or take medicines that significantly lower potassium and magnesium in the blood.

Before starting treatment with Trisenox, tell your doctor if you have any of these conditions.