Clinical Trial: TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer

This study has been completed.

Sponsored by: Telik
Information provided by: Telik

Purpose

The purpose of this study is to demonstrate superiority in survival in favor of TLK286 as compared to active control therapy with Doxil/Caelyx or Hycamtin in the intent-to-treat (ITT) populations.

Condition Treatment or Intervention Phase
Ovarian Neoplasms
 Drug: TLK286 HCl for injection
 Drug: topotecan hydrochloride for injection
 Drug: doxorubicin HCl liposome injection
Phase III

MedlinePlus related topics:  Ovarian Cancer

Study Type: Interventional
Study Design: Treatment, Randomized, Open Label, Active Control, Safety/Efficacy Study

Official Title: Phase 3 Randomized Study of TLK286 (Telcyta) versus Doxil/Caelyx or Hycamtin as Third-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-1 (Assessment of Survival In Solid Tumors-1)]

Further Study Details: 

Expected Total Enrollment:  440

Study start: April 2003

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Female

Criteria

Inclusion criteria include:

  • Considered platinum refractory or resistant according to standard criteria
  • Progressed during or following completion of one second-line treatment with Doxil/Caelyx or Hycamtin
  • Histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube, or primary peritoneal cancer
  • Measurable disease according to RECIST criteria with documented tumor progression

Exclusion criteria include:

  • Treatment with second-line chemotherapy other than Doxil/Caelyx or Hycamtin
  • History of whole pelvis radiation therapy within 12 months of enrollment
  • Clinically significant cardiac disease
  • Evidence of gross hematuria at the time of study entry
  • Any signs of intestinal obstruction interfering with nutrition at the time of study entry
  • Pregnant or lactating women

Location Information


Arkansas
      Little Rock Hematology Oncology Associates, Little Rock,  Arkansas,  72205,  United States

      University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States

California
      Southwest Cancer Care, Poway,  California,  92064,  United States

      David Geffen School of Medicine at UCLA, Los Angeles,  California,  90095,  United States

      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States

      Gyncologic Oncology Associates, Newport Beach,  California,  92663,  United States

      Southwest Cancer Care, Escondido,  California,  92025,  United States

      Southwest Cancer Care, Murrieta,  California,  92562,  United States

      Sharp Healthcare Clinical Oncology Research, San Diego,  California,  92123,  United States

      Bay Area Research Cancer Group, Concord,  California,  94520,  United States

      Gynecologic Oncology Associates, La Jolla,  California,  92037,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Vallejo,  California,  94589,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Oakland,  California,  94611,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Sacramento,  California,  95825,  United States

      Kaiser Permanente Oncology Clinical Trials Program, San Francisco,  California,  94115,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Santa Clara,  California,  95051,  United States

      Kaiser Permanente Oncology Clinical Trails Program, Santa Teresa,  California,  95119,  United States

      Kaiser Permanente Oncology Clinial Trials Program, Walnut Creek,  California,  94596,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Hayward,  California,  94545,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Roseville,  California,  95661,  United States

      Kaiser Permanente Oncology Clinical Trials Program, San Rafael,  California,  94903,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Santa Rosa,  California,  95403,  United States

      Kaiser Permanente Oncology Clinical Trials Program, South San Francisco,  California,  94080,  United States

      Kaiser Permanente Oncology Clinical Trials Program, Redwood City,  California,  94063,  United States

      Sharp Memorial Hospital, San Diego,  California,  92123,  United States

      Grossmont Hospital, La Mesa,  California,  91942,  United States

      Sharp Rees-Stealy, San Diego,  California,  92123,  United States

      Sharp Rees-Stealy, La Mesa,  California,  91942,  United States

      Medical Oncology Associates-SD, San Diego,  California,  92123,  United States

      Rosalba Rodriguez, M. D., Chula Vista,  California,  91911,  United States

      Marilyn Norton, M. D., Chula Vista,  California,  91911,  United States

      N. County Oncology Medical, Oceanside,  California,  92056,  United States

      LLU Faculty Medical Offices, Loma Linda,  California,  92354,  United States

      Southern California Permanente Medical Group, San Diego,  California,  92120,  United States

      Southern California Permanente Medical Group, Baldwin Park,  California,  91706,  United States

      California Oncology of the Central Valley, Fresno,  California,  93710,  United States

      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States

      LLU Faculty Meidical Offices, Loma Linda,  California,  92354,  United States

      Women's Cancer Center - Community Hospital Los Gatos, Los Gatos,  California,  95032,  United States

      Providence Saint Joseph Medical Center, Burbank,  California,  91505-4866,  United States

Connecticut
      Whittingham Cancer Center at Norwalk Hospital, Norwalk,  Connecticut,  06856,  United States

      Hematology Oncology, P.C., Stamford,  Connecticut,  06902,  United States

Florida
      Gynecologic Oncology, Orlando,  Florida,  32804,  United States

      Women's Cancer Research Foundation, Inc., S. Miami,  Florida,  33143,  United States

      Sheridan Clinical Research, Inc., Hollywood,  Florida,  33021,  United States

      University of Florida Health Science Center/Jacksonville, Jacksonville,  Florida,  32209,  United States

      Florida Hospital, Orlando,  Florida,  32803,  United States

      Memorial Regional Hospital, Hollywood,  Florida,  33021,  United States

      Gynecologic Oncology Associates, Pembroke Pines,  Florida,  33028,  United States

      Palm Beach Cancer Institute, West Palm Beach,  Florida,  33401,  United States

      Palm Beach Cancer Institute, Palm Beach Gardens,  Florida,  33410,  United States

      Palm Beach Cancer Institute, Wellington,  Florida,  33414,  United States

      Sheridan Clinical Research, Inc., Hollywood,  Florida,  33021,  United States

      Memorial Regional Hospital, Hollywood,  Florida,  33021,  United States

      Gynecologic Oncology Associates, Pembroke Pines,  Florida,  33028,  United States

      The Center for Hematology-Oncology, Boca Raton,  Florida,  33486,  United States

      The Center for Hematology-Oncology, Delray Beach,  Florida,  33484,  United States

      Hematology/Oncology Associates of Treasure Coast, Port St. Lucie,  Florida,  34952,  United States

      Florida Hospital Memorial Division, Cancer Care Center, Ormond Beach,  Florida,  32174,  United States

      Florida Hospital Memorial Division, Ormond Beach,  Florida,  32174,  United States

Georgia
      Suburban Hematology-Oncology Associates, Lawrenceville,  Georgia,  30045,  United States

      Memorial Health University Medical Center, Savannah,  Georgia,  31404,  United States

      Suburban Hematology Oncology, Snellville,  Georgia,  30078,  United States

      Suburban Hematology Oncology, Duluth,  Georgia,  30096,  United States

Hawaii
      Univ. of Hawaii, Kapiolani Medical Center for Women and Children, Honolulu,  Hawaii,  96826,  United States

      Straub Clinic and Hospital, Honolulu,  Hawaii,  96826,  United States

      Kaiser Permanente - Moanalua Medical Center, Honolulu,  Hawaii,  96819,  United States

Illinois
      MacNeal Cancer Center, Berwyn,  Illinois,  60402,  United States

      Cancer Care Specialists of Central IL, Decatur,  Illinois,  62526,  United States

      Cancer Care Specialists of Central IL-Crossroads Cancer Care Center, Effingham,  Illinois,  62401,  United States

      Decatur Memorial Hospital, Decatur,  Illinois,  62526,  United States

      Joliet Oncology-Hematology Associates, Ltd., Joliet,  Illinois,  60435,  United States

      Joliet Oncology-Hematology Associates, Ltd., Morris,  Illinois,  60450,  United States

      Joliet Oncology-Hematology Associates, Ltd., Flossmoor,  Illinois,  60422,  United States

      Hematology Oncology Associates of Illinois (HOAI), Chicago,  Illinois,  60657,  United States

      Hematology Oncology Associates of Illinois (HOAI), Skokie,  Illinois,  60076,  United States

      Swedish Covenant Cancer Center, Chicago,  Illinois,  60625,  United States

      North Shore Oncology Hematology Associates - Deerpath Medical Associates, Lake Forest,  Illinois,  60045,  United States

      North Shore Oncology Hematology Associates, Barrington,  Illinois,  60010,  United States

      North Shore Oncology Hematology Associates, Libertyville,  Illinois,  60048,  United States

      North Shore Oncology Hematology Associates, McHenry,  Illinois,  60050,  United States

      Midwest Cancer Research Group, Inc., Skokie,  Illinois,  60077,  United States

Indiana
      Indiana University Medical Center, Indianapolis,  Indiana,  46202,  United States

      St. Joseph's Regional, South Bend,  Indiana,  46617,  United States

      St. Vincent Gynecologic Oncology, Indianapolis,  Indiana,  46260,  United States

      Michiana Hematology Oncology, Elkhart,  Indiana,  46514,  United States

      St. Vincent Hospital and Health Care Center, Indianapolis,  Indiana,  46260,  United States

      Indiana Cancer Pavilion, Indianapolis,  Indiana,  46202,  United States

      Saint Joseph's Regional, South Bend,  Indiana,  46634,  United States

      Elkhart General Hospital, Elkhart,  Indiana,  46514,  United States

      Michiana Hematology Oncology, South Bend,  Indiana,  46617,  United States

      St. Vincent Hospital and Helath Care Center, Indianapolis,  Indiana,  46260,  United States

Iowa
      University of Iowa, Iowa City,  Iowa,  52242,  United States

      University of Iowa Hospitals and Clinics, Iowa City,  Iowa,  52242,  United States

Kansas
      Associates in Women's Health, Wichita,  Kansas,  67214,  United States

      Research Support Personnel, LLC, Wichita,  Kansas,  67208,  United States

Kentucky
      Oncology/Hematology Care, Inc., Crestview,  Kentucky,  41017,  United States

      Univ. of Louisville, Div. of Gynecologic Oncology, Louisville,  Kentucky,  40202,  United States

Louisiana
      LSU Health Sciences Center, Shreveport,  Louisiana,  71103,  United States

      Ochsner Clinic Foundation, New Orleans,  Louisiana,  70121,  United States

      Hematology and Oncology Specialists, LLC, New Orleans,  Louisiana,  70115,  United States

      Hematology and Oncology Specialists, LLC, Covington,  Louisiana,  70433,  United States

      OncRx (Pharmacy), Metairie,  Louisiana,  70002,  United States

Maryland
      Center for Cancer and Blood Disorders, Bethesda,  Maryland,  20817,  United States

      Sinai Cancer Institute, Baltimore,  Maryland,  21205,  United States

Massachusetts
      St. Elizabeth's Med. Ctr., Boston,  Massachusetts,  02135,  United States

Michigan
      Sparrow Regional Cancer Center, Lansing,  Michigan,  48909,  United States

      St. Joseph Mercy Hospital, Ann Arbor,  Michigan,  48106,  United States

Minnesota
      St. Mary's Duluth Clinic, Duluth,  Minnesota,  55805,  United States

Missouri
      Gynecology & Oncology Consultants, PC, St. Louis,  Missouri,  63141,  United States

      Ellis Fischel Cancer Center, Columbia,  Missouri,  65203,  United States

      St. Louis University, Dept. of Ob-Gyn and Women's Health, St. Louis,  Missouri,  63117,  United States

      Saint John's Mercy Hospital, St. Louis,  Missouri,  63141,  United States

Montana
      Hematology & Oncology Centers Northern Rockies, Billings,  Montana,  59101,  United States

      Deaconess Billings Clinic, Billings,  Montana,  59101,  United States

      Hematology Oncology Centers of the Northern Rockies, Butte,  Montana,  59701,  United States

      Hematology Oncology Centers of the Northern Rockies, Butte,  Montana,  59701,  United States

Nebraska
      Horizon's West Medical Group, Scottsbluff,  Nebraska,  69361,  United States

Nevada
      Nevada Cancer Center, Las Vegas,  Nevada,  89109,  United States

New Jersey
      The Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08901,  United States

      Jersey Shore University Medical Center, Neptune,  New Jersey,  07754,  United States

      Robert Wood Johnson University Hospital, New Brunswick,  New Jersey,  08903,  United States

New Mexico
      UNM Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131,  United States

New York
      The Mary Imogene Bassett Hospital, Cooperstown,  New York,  13326,  United States

      NYU School of Medicine, New York,  New York,  10016,  United States

      The Union State Bank Cancer Center at Nyack Hospital, Nyack,  New York,  10960,  United States

      Med-Onc/Hem, Malone,  New York,  12953,  United States

      Gynecologic-Oncology, Rochester,  New York,  14620,  United States

      Memorial Sloan Kettering Cancer Center, New York,  New York,  11021,  United States

      Good Samaritan Hospital Medical Center, West Islip,  New York,  11795,  United States

      Benjamin Schwartz, M.D., Babylon,  New York,  11702,  United States

      South Bay OB/GYN, West Islip,  New York,  11795,  United States

      Hematology-Oncology Associates of Rockland, New City,  New York,  10956,  United States

      Comprehensive Cancer Center Medical Practice Offices, New York,  New York,  10016,  United States

      Bellevue Hospital Center, New York,  New York,  10016,  United States

      North Shore-Long Island Jewish Health System/Medical Center, New Hyde Park,  New York,  11040,  United States

      New York University Medical Center - Tisch Hospital, New York,  New York,  10016,  United States

      Long Island Jewish Medical Center, New Hyde Park,  New York,  11040,  United States

North Carolina
      Piedmont Hematology Oncology Assoc., PA-Salem Research Group, Winston Salem,  North Carolina,  27103,  United States

      Wake Forest University School of Medicine, Winston Salem,  North Carolina,  27157,  United States

      Blumenthal Cancer Center, Charlotte,  North Carolina,  28203,  United States

      Salem Research Group, Inc., Winston Salem,  North Carolina,  27103,  United States

      Presbyterian Hospital Center for Cancer Research, Charlotte,  North Carolina,  28204,  United States

      Presbyterian Gynecologic Oncology, Charlotte,  North Carolina,  28204,  United States

North Dakota
      Dakota Cancer Institute, Fargo,  North Dakota,  58103,  United States

      Mid Dakota Clinic, Bismarck,  North Dakota,  58501,  United States

      Odyssey Research Services, Bismarck,  North Dakota,  58501,  United States

      Odyssey Research Services, Fargo,  North Dakota,  58104,  United States

Ohio
      Gynecologic Oncology, Columbus,  Ohio,  43222,  United States

      Mid-Ohio Oncology Hematology, Columbus,  Ohio,  43213,  United States

      Mid-Ohio Oncology Hematology St. Anne's, Columbus,  Ohio,  43081,  United States

      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45242,  United States

      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45236,  United States

      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45013,  United States

      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45230,  United States

      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45219,  United States

      Wright State Univ. School of Medicine, Dayton,  Ohio,  45409,  United States

      MetroHealth Medical Center, Cleveland,  Ohio,  44109,  United States

      University Hospital, Cincinnati,  Ohio,  45219,  United States

      Hillcrest Hospital Cancer Center, Mayfield Heights,  Ohio,  44124,  United States

      Barrett Cancer Center, Cincinnati,  Ohio,  45219,  United States

      UC Physician's Medical Arts Bldg., Cincinnati,  Ohio,  45219,  United States

      Mount Carmel Health, Columbus,  Ohio,  43222,  United States

      Mid Ohio Oncology Hematology, Columbus,  Ohio,  43213,  United States

      Metro Health Medical Center, Cleveland,  Ohio,  44109,  United States

Oklahoma
      University of Oklahoma Health Sciences Center, Oklahoma City,  Oklahoma,  73104,  United States

      OU Medical Center - Everett Tower, Oklahoma City,  Oklahoma,  73104,  United States

      Presbyterian, Oklahoma City,  Oklahoma,  73104,  United States

      OU Physicians' Bldg., Oklahoma City,  Oklahoma,  73104,  United States

Oregon
      Oregon Health Science University, Portland,  Oregon,  97239,  United States

      Kaiser Permanente Nw, Oncology Research, Portland,  Oregon,  97227,  United States

      Oregon Health & Science University, Portland,  Oregon,  97239-3098,  United States

Pennsylvania
      Hematology & Oncology Associates of NEPA, Dunmore,  Pennsylvania,  18512,  United States

      Magee-Womens Hospital, Pittsburgh,  Pennsylvania,  15213,  United States

      Abington Mem. Hospita/Rosenfield Cancer Center, Abington,  Pennsylvania,  19001,  United States

      Mercy Health Partners, Scranton,  Pennsylvania,  18510,  United States

      Moses Taylor Hospital, Scranton,  Pennsylvania,  18510,  United States

      Community Medical Center, Scranton,  Pennsylvania,  18510,  United States

      Viewmont Medical Services, Scranton,  Pennsylvania,  18508,  United States

      Advanced Imaging, Dunmore,  Pennsylvania,  18512,  United States

      Associates in Hematology-Oncology, P.C., Upland,  Pennsylvania,  19013,  United States

South Carolina
      Gynecologic Oncology Research and Development, Greenville,  South Carolina,  29605,  United States

      Carolina Center of Gynecologic Oncology, PA, Charleston,  South Carolina,  29407,  United States

      Gynecologic Oncology Research and Development, Spartanburg,  South Carolina,  29303,  United States

      South Carolina Oncology Associates, PA, Columbia,  South Carolina,  29201,  United States

South Dakota
      Sioux Calley Clinic OBGYN Ltd., Sioux Falls,  South Dakota,  57105,  United States

      Sioux Valley Clinic Clinical Research Center, Sioux Falls,  South Dakota,  57104,  United States

      Sioux Valley Clinic Oncology, Sioux Falls,  South Dakota,  57104,  United States

      Sioux Valley Hospital - North Center Radiology, Sioux Falls,  South Dakota,  57104,  United States

Tennessee
      The Consultant Group, Nashville,  Tennessee,  37205,  United States

      Fort Sanders Parkwest Medical Center, Knoxville,  Tennessee,  37923,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37203,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37211,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Hermitage,  Tennessee,  37076,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37207,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Murfreesboro,  Tennessee,  37130,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37205,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Gallatin,  Tennessee,  37066,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Lebanon,  Tennessee,  37087,  United States

      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Smyma,  Tennessee,  37167,  United States

      Memorial Hospital, Chattanooga,  Tennessee,  37404,  United States

      Chattanooga Oncology & Hematology Associates, P.C., Chattanooga,  Tennessee,  37404,  United States

      Saint Mary's Health System, Inc., Knoxville,  Tennessee,  37917,  United States

      Hall and Martin, M.D.'s, P.C., Knoxville,  Tennessee,  37920,  United States

      The Consultant Group, Franklin,  Tennessee,  37067,  United States

Texas
      Arlington Cancer Center, Arlington,  Texas,  76012,  United States

      Univ. of TX, MD Anderson Cancer Center, Houston,  Texas,  77030,  United States

      Texas Cancer Associates, Dallas,  Texas,  75231,  United States

      Texas Oncology, PA, Fort Worth,  Texas,  76104,  United States

      Southwest Fort Worth Cancer Center, Fort Worth,  Texas,  76132,  United States

      Amarillo Cancer Center, Amarillo,  Texas,  79106,  United States

      Dallas Oncology Consultants, Dallas,  Texas,  75201,  United States

Virginia
      Danville Hematology and Oncology, Inc., Danville,  Virginia,  24541,  United States

Washington
      Western Washington Oncology, Olympia,  Washington,  98502,  United States

      MultiCare Health System - Medical Oncology, Tacoma,  Washington,  98405,  United States

      Western Washington Oncology, Olympia,  Washington,  98506,  United States

      Western Washington Oncology, Centralia,  Washington,  98531,  United States

      Western Washington Oncology, Shelton,  Washington,  98584,  United States

      Western Washington Oncology, Aberdeen,  Washington,  98520,  United States

      Allenmore Hospital - Hematology Oncology Clinic, Tacoma,  Washington,  98405,  United States

      Covington Multicare - Oncology Clinic, Covington,  Washington,  98042,  United States

Wisconsin
      Medical Consultants, Ltd., Milwaukee,  Wisconsin,  53215,  United States

      Marshfield Clinic Research Foundation, Marshfield,  Wisconsin,  54449,  United States

      Saint Joseph's Hospital, Marshfield,  Wisconsin,  54449,  United States

      Chippewa Falls Cancer Center, Chippewa Falls,  Wisconsin,  54729,  United States

      Merrill Cancer Center, Merrill,  Wisconsin,  54452,  United States

      Wausau Cancer Center, Wausau,  Wisconsin,  54401,  United States

      Wisconsin Rapid Cancer Center, Marshfield,  Wisconsin,  54494,  United States

      Regional Cancer Center, Eau Claire,  Wisconsin,  54701,  United States

      Saint Michael Hospital, Stevens Point,  Wisconsin,  54481,  United States

      Marshfield Clinic - Indianhead Center, Rice Lake,  Wisconsin,  54868,  United States

      Marshfield Clinc - Lakeland Center, Minocqua,  Wisconsin,  54548,  United States

      Marshfield Clinic - Lakeland Center, Minocqua,  Wisconsin,  54548,  United States

      Marshfield Clinic - Lakeland Center, Minocqua,  Wisconsin,  54548,  United States

      Diagnostic Radiology Associates, Rice Lake,  Wisconsin,  54868,  United States

      Lakeview Medical Center, Rice Lake,  Wisconsin,  54868,  United States

Wyoming
      Hematology Oncology Centers of the Northern Rockies, Cody,  Wyoming,  82414,  United States

      Hematology Oncology of the Northern Rockies, Sheridan,  Wyoming,  82801,  United States

Argentina
      Sociedad de Beneficencia Hospital Italiano, Cordoba,  Argentina

      Hospital Donacion Francisco Santojanni, Buenos Aires,  1408,  Argentina

      Complejo Medico de la Policia Federal Argentina "Churruca-Visca", Buenos Aires,  1437,  Argentina

      Sanatorio Municipal Dr. Julio Mendez, Buenos Aires,  C1405CNF,  Argentina

      Complejo Medico de la Policia Federal Argentina "Churruca-Visca", Buenos Aires,  C1437JCP,  Argentina

      Hospital General de Agudos "Carlos G. Durand", Buenos Aires,  C1405DCS,  Argentina

      Hospital Italiano de Buenos Aires, Buenos Aires,  C1181ACH,  Argentina

      Policlinica Privada Instituto de Medicina Nuclear, Buenos Aires,  Argentina

      Hospital de Oncologia Maria Curie, Buenos Aires,  Argentina

Argentina, Buenos Aires
      Hospital General de Agudos Donacion F. Santojanni, Capital Federal,  Buenos Aires,  1408,  Argentina

      Hospital Universitario Austral, Pilar,  Buenos Aires,  B1629AHJ,  Argentina

      Hospital Italiano Regional del Sur, Bahia Blanca,  Buenos Aires,  B8001HXM,  Argentina

Argentina, Santa Fe
      ISIS Clinica Especializada, Sante Fe,  Santa Fe,  03000,  Argentina

Belgium
      Cliniques Universitaires Saint-Luc, Brussels,  B 1200,  Belgium

      Universitair Ziekenhuis Gent., Gent,  9000,  Belgium

      AZ-VUB Dienst Oncologie, Brussels,  1090,  Belgium

      Centre Hospitalier Regional de la Citadelle, LIEGE,  4000,  Belgium

Belgium, Antwerpen
      Algemeen Ziekenhuis Antwerpen, Lindedreef,  Antwerpen,  2020,  Belgium

Belgium, Edegem
      Universitaire Ziekenhuis Antwerpen, Wilrijkstraat,  Edegem,  2650,  Belgium

Belgium, Leuven
      University Hospital Gasthuisberg, Herestraat,  Leuven,  49,  Belgium

Brazil
      INCA Hospital de Oncologia Clinica, Rio de Janeiro,  20220-410,  Brazil

      Instituto de Saude e Bem Estar da Mulher, Sao Paolo,  Brazil

      Hospital do Cancer - A.C. Camargo, Sao Paolo,  01509,  Brazil

      UNIFESP/EPM, Sao Paulo,  04024-002,  Brazil

Brazil, CE
      Instituto do Cancer do Ceara, Fortaleza,  CE,  60430-230,  Brazil

Brazil, MG
      Hospital Luxemburgo, Belo Horizonte,  MG,  32380,  Brazil

      Hospital Vera Cruz, Belo Horizonte,  MG,  30190-130,  Brazil

Brazil, PR
      Hospital de Clinicas da Universidade Federal do Parana, Curitiba,  PR,  Brazil

      Centro de Tratamento Oncologico de Londrina, Londrina,  PR,  86010-640,  Brazil

Brazil, Porto Alegre
      Hospital de Clinicas de Porto Alegre, Bairro Bom Fim,  Porto Alegre,  90035-003,  Brazil

Brazil, SP
      Hospital das Clinicas de Sao Paulo-FMUSP, Sao Paolo,  SP,  05403,  Brazil

      Instituto Arnaldo Vieira de Carvalho, Sao Paolo,  SP,  01223,  Brazil

Chile
      Clinica Santa Maria, Santiago de Chile,  Chile

Chile, Santiago
      Servicio de Oncologia-Hospital Clinico Unversidad de Chile, Independencia,  Santiago,  Santos Dumontt 999,  Chile

Czech Republic
      Masarykuv Onkologicky Ustav, Brno,  656 53,  Czech Republic

      Fakultni nemocnice, Onkologicka klinika, Plzen,  Czech Republic

Czech Republic, Olomouc
      Fakultni nemocnice Olomouc, Onkologicka klinika, Pardubice,  Olomouc,  77520,  Czech Republic

Czech Republic, Pardubice
      Krajska nemocnice Pardubice, Oddeleni radiacni onklogie, Kyjevska 44,  Pardubice,  53203,  Czech Republic

Czech Republic, Plzen
      Fakultni Nemocnice - Onkologicka Klinika, Doudlevecka 69,  Plzen,  301 31,  Czech Republic

Czech Republic, Praha
      Vseobecna Fakultni Nemocnice - Onkologicka Klinika, Unemocnice,  Praha,  12808,  Czech Republic

Czech Republic, Zlin
      Batova krajska nemocnice Zlin, prispevkova organizace, Onkologicke oddeleni, Havlickovo nabrezi 600,  Zlin,  76001,  Czech Republic

      Batova krajska nemocnice Zlin, prispevkova organizace, Radiodiagnosticke oddeleni, Havlickovo nabrezi,  Zlin,  76001,  Czech Republic

Germany
      St. Vincentius Kliniken - Frauenkinik, Karlsruhe,  D76137,  Germany

      Klinikum GroBhadern-Zentrum fur Frauenheilkunde, Munich,  D81377,  Germany

      Klinikum GroBhadern-Institut fur Radiologie, Munich,  D-81377,  Germany

      St. Vincentius Kliniken - Radiology, Karlsruhe,  D76137,  Germany

      Universitaets-Frauenklinik Ulm, Ulm,  D89075,  Germany

      Dr. Horst-Schmidt-Kliniken GmbH, Wiesbaden,  D65199,  Germany

      Universitatsklinikum Charite - Campus Virchow-Klinikum, Berlin,  D13353,  Germany

      St. Vincentius Kliniken, Karlsruhe,  D-76137,  Germany

Hungary
      SZTE, Department of Oncotherapy, Szeged,  6720,  Hungary

      Faculty of Gynaecologycal Oncology/Univ. of Debrecen, Debrecen,  4032,  Hungary

      Baranya County Hospital, Pecs,  7632,  Hungary

      Uzsoki Street Hospital Dept. of Radiooncology, Budapest,  H-1145,  Hungary

      Semmelweis University, 1st Dept. of Obstetrics and Gynaecology, Baross,  H-1088,  Hungary

      Baranya County Hospital - Department of Oncology, Rakoczi,  Hungary

      Baranya County Hospital - Department of Radiology, Rakoczi,  Hungary

Ireland
      Oncology Dept., University Floor, Belfast City Hospital, Belfast,  BT9 7AB,  Ireland

Netherlands
      Vrije Universiteit Medical Centre (VUMC), HV Amsterdam,  1081,  Netherlands

      University Medical Centre Nijmegen (UMCN), Nijmegen,  6525,  Netherlands

South Africa
      Eastern Cape Oncology Research Centre, Port Elizabeth,  6001,  South Africa

South Africa, Cape Town
      Panorama Medical Centre, Panorama,  Cape Town,  7500,  South Africa

South Africa, Durban
      Hopelands Cancer Centre, Overport,  Durban,  4091,  South Africa

South Africa, Johannesburg
      Rosebank Oncology Centre, Saxonwold,  Johannesburg,  2196,  South Africa

      Medical and Dental Centre, Rosebank,  Johannesburg,  2196,  South Africa

South Africa, Pretoria
      Wilgers Oncology Centre, Die Wilgers x14,  Pretoria,  41,  South Africa

Spain
      Servicio de Oncologia, Madrid,  28007,  Spain

      Hospital Clinic i Provincial, Barcelona,  8035,  Spain

      Hospital General de Guadalajara, Guadalajara,  Spain

      Instituto Valenciano de Oncologia (IVO) Servicio de Oncologia, Valencia,  46009,  Spain

      Instituto Valenciano de Oncologia (IVO) Servicio de Radiologia, Valencia,  46009,  Spain

      Hospital Clinic i Provincial de Barcelona - Servicio de Oncologia Medica, Barcelona,  08036,  Spain

Spain, Barcelona
      Servicio Oncologia Hospital General Vall d'HebronPaseo, Vall d'Hebron,  Barcelona,  119-129,  Spain

Spain, Valencia
      Instituto Valenciano de Oncologia (IVO), Profesor Beltran Baguena,  Valencia,  46009,  Spain

United Kingdom
      Department of Medical Oncology, Christie Hospital, Manchester,  M20 4BX,  United Kingdom

      St. Chad's Outpatients Unit, City Hospital, Birmingham,  B18 7QH,  United Kingdom

      Beatson Oncology Centre, Glasgow,  G11 6NT,  United Kingdom

      Medical Oncology (NCCT) - Newcastle General Hospital, Newcastle upon Tyne,  NE4 6BE,  United Kingdom

      Medical Oncology - Guy's and St. Thomas' Hospital, London,  SE1 9RT,  United Kingdom

      Dorset Cancer Centre - Poole Hospital, Poole,  BH15 2JB,  United Kingdom

      Beatson Oncology Unit, Glasgow,  G11 6NT,  United Kingdom

      United Bristol Healthcare Trust - Bristol Oncology Centre, Bristol,  BS2 8ED,  United Kingdom

      Velindre NHS Trust - Velindre Hospital, Wales,  CFT142TL,  United Kingdom

      Department of Medicine-Royal Marsden Hospital, London,  SW3 6JJ,  United Kingdom

United Kingdom, Dundee
      Department of Cancer Medicine - Ninewells Hospital & Medical School, Scotland,  Dundee,  DD1 9SY,  United Kingdom

United Kingdom, Surrey
      Dept. of Med. Oncology/The Royal Marsden Hospital, Sutton,  Surrey,  SMT 5PT,  United Kingdom

More Information

Study ID Numbers:  TLK286.3017
Record last reviewed:  February 2005
Last Updated:  February 8, 2005
Record first received:  April 7, 2003
ClinicalTrials.gov Identifier:  NCT00057720
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

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