Clinical Trial: Immunotherapy Using Cyclosporine, Interferon gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma

This study is currently recruiting patients.

Sponsors and Collaborators: Children's Oncology Group
National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)


RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Giving immunotherapy using cyclosporine, interferon gamma, and interleukin-2 after stem cell transplantation may help the transplanted cells kill more cancer cells. It is not yet known whether high-dose chemotherapy followed by autologous stem cell transplantation is more effective with or without immunotherapy.

PURPOSE: Randomized phase II/III trial to compare the effectiveness of high-dose chemotherapy followed by autologous stem cell transplantation with or without immunotherapy using cyclosporine, interferon gamma, and interleukin-2 in treating patients who have refractory or relapsed Hodgkin's lymphoma.

Condition Treatment or Intervention Phase
recurrent adult Hodgkin's lymphoma
recurrent/refractory childhood Hodgkin's lymphoma
 Drug: carmustine
 Drug: cyclosporine
 Drug: cytarabine
 Drug: etoposide
 Drug: filgrastim
 Drug: interferon gamma
 Drug: interleukin-2
 Drug: melphalan
 Procedure: autologous bone marrow transplantation
 Procedure: biological response modifier therapy
 Procedure: bone marrow ablation with stem cell support
 Procedure: bone marrow transplantation
 Procedure: chemotherapy
 Procedure: colony-stimulating factor therapy
 Procedure: cytokine therapy
 Procedure: graft versus host disease prophylaxis/therapy
 Procedure: graft versus tumor induction
 Procedure: high-dose chemotherapy
 Procedure: interferon therapy
 Procedure: interleukin therapy
 Procedure: non-specific immune-modulator therapy
 Procedure: peripheral blood stem cell transplantation
 Procedure: supportive care/therapy
Phase II
Phase III

MedlinePlus related topics:  Hodgkin's Disease

Study Type: Interventional
Study Design: Treatment

Official Title: Phase II/III Randomized Study of Immunotherapy Comprising Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Patients With Refractory or Relapsed Hodgkin's Lymphoma

Further Study Details: 



OUTLINE: This is a nonrandomized, multicenter phase II study followed by a randomized, multicenter phase III study. Patients are stratified according to study phase (II vs III).

Patients receive 2 courses of salvage induction therapy on COG-AHOD00P1 or equivalent. Within 2-5 weeks after completion of salvage induction therapy, patients receive protocol therapy.

  • All patients receive the following treatment:
  • Hyperfractionated involved-field radiotherapy: Patients who have completed prior salvage induction therapy and have not received full tissue tolerance from prior radiotherapy may receive hyperfractionated involved-field radiotherapy twice daily for 7 days.
  • High-dose preparative regimen: Beginning within 7 days after radiotherapy, patients receive carmustine IV over 3 hours on day -6; etoposide IV over 1 hour and cytarabine IV over 1 hour on days -5 to -2; and melphalan IV over 30 minutes on day -1.
  • Autologous stem cell transplantation: Patients undergo autologous bone marrow or peripheral blood stem cell transplantation on day 0. Patients then receive filgrastim (G-CSF) subcutaneously (SC) or IV beginning on day 1 and continuing until blood counts recover.
  • Immunotherapy: Patients receive cyclosporine IV twice daily beginning on day 0 and continuing until the completion of the course of interferon gamma and interleukin-2. When sufficiently recovered, patients also receive interferon gamma SC every other day for 10 doses. Beginning 2 days after the start of interferon gamma, patients also receive interleukin-2 SC once daily for 18 days.
  • Patients who respond to prior salvage induction therapy are randomized to 1 of 2 treatment arms. Patients who have progressive disease after 2 courses of prior salvage induction therapy are assigned to arm I.
  • Arm I: Patients receive treatment as in phase II.
  • Arm II: Patients receive treatment as in phase II without immunotherapy. In both phases, treatment continues in the absence of disease progression or unacceptable toxicity.

Patients are followed at 1 year.

PROJECTED ACCRUAL: A total of 156 patients (25 for phase II and 131 for phase III) will be accrued for this study within 5.4 years.


Ages Eligible for Study:  up to  30 Years,  Genders Eligible for Study:  Both



  • Diagnosis of Hodgkin's lymphoma
  • Histologically confirmed at original diagnosis AND at relapse or disease progression
  • Relapsed or refractory to conventional therapy
  • No recurrence without B symptoms or bulky disease at least 1 year after completion of minimal systemic therapy defined by either of the following:
  • Stage IA/IIA with nodal disease previously treated with radiotherapy only
  • Stage IA/IIA with nodal disease previously treated with less than 3 courses of standard dose chemotherapy
  • Concurrently enrolled on the COG-AHOD00P1 salvage chemotherapy study OR received other appropriate salvage therapy (e.g., ifosfamide and vinorelbine)


  • Under 30

Performance status

  • ECOG 0-2 (for adults)
  • Lansky 50-100% (for children)

Life expectancy

  • At least 2 months



  • Bilirubin no greater than 1.5 times normal
  • SGPT less than 2.5 times normal


  • Creatinine no greater than 1.5 times normal OR
  • Creatinine clearance or radioisotope glomerular filtration rate at least 70 mL/min/1.73 m^2


  • Shortening fraction at least 27% by echocardiogram OR
  • Ejection fraction at least 50% by MUGA


  • No evidence of dyspnea at rest
  • No exercise intolerance
  • DLCO at least 50% (patients 8 years of age and over)


  • Not pregnant or nursing
  • Negative pregnancy test
  • No concurrent serious illness


  • Recovered from prior immunotherapy
  • At least 1 week since prior antineoplastic biologic agents
  • More than 1 week since prior growth factors
  • No prior stem cell transplantation
  • No other concurrent immunomodulating agents


  • See Disease Characteristics
  • More than 2 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas) and recovered
  • No other concurrent anticancer chemotherapy

Endocrine therapy

  • No concurrent steroids, including dexamethasone as an antiemetic


  • See Disease Characteristics
  • Recovered from prior radiotherapy


  • Not specified


  • No concurrent participation in another COG therapeutic study

Location and Contact Information

      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35233,  United States; Recruiting
Robert P. Castleberry, MD  205-939-9285 

      University of South Alabama Cancer Research Institute, Mobile,  Alabama,  36604,  United States; Recruiting
Felicia L. Wilson, MD  251-405-5115 

      Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson,  Arizona,  85724,  United States; Recruiting
Rochelle Bagatell, MD  520-626-4851 

      Phoenix Children's Hospital, Phoenix,  Arizona,  85016,  United States; Recruiting
Jessica Boklan, MD  602-546-0920 

      Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States; Recruiting
David L. Becton, MD  501-320-5650 

      Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange,  California,  92868,  United States; Recruiting
Stanley Calderwood, MD  714-456-6615 

      Children's Hospital and Health Center, San Diego, San Diego,  California,  92123-4282,  United States; Recruiting
Richard Kadota, MD  858-966-5811 

      Children's Hospital and Research Center at Oakland, Oakland,  California,  94609-1809,  United States; Recruiting
James H. Feusner, MD  510-428-3000 

      Children's Hospital Central California, Madera,  California,  93638-8762,  United States; Recruiting
Vonda Lee Crouse, MD  559-353-5480 

      Children's Hospital Los Angeles, Los Angeles,  California,  90027-0700,  United States; Recruiting
Paul S. Gaynon, MD  323-669-2163 

      Children's Hospital of Orange County, Orange,  California,  92868,  United States; Recruiting
Wei-Ping Violet Shen, MD  714-516-4348 

      General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base,  California,  94535,  United States; Recruiting
Peter J. Chenaille, MD  707-423-7176 

      Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach,  California,  90801-1428,  United States; Recruiting
William Mark Roberts, MD  562-933-8600 

      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States; Recruiting
Stephen A. Feig, MD  310-825-5268 

      Kaiser Permanente Medical Center - Sacramento, Sacramento,  California,  95825,  United States; Recruiting
Vincent A. Kiley, MD  916-973-7331 

      Kaiser Permanente Medical Center - Santa Clara, Santa Clara,  California,  95051-5386,  United States; Recruiting
Carolyn Lucille Russo, MD  408-236-5028 

      Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego,  California,  92120,  United States; Recruiting
Wellington Loh, MD  619-516-6144 

      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States; Recruiting
Antranik Bedros, MD  909-558-8626 

      Lucile Packard Children's Hospital at Stanford University Medical Center, Palo Alto,  California,  94304,  United States; Recruiting
Neyssa M. Marina, MD  650-723-5535 

      Rebecca and John Moores UCSD Cancer Center, La Jolla,  California,  92093-0658,  United States; Recruiting
Richard Kadota, MD  858-657-7020 

      Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles,  California,  90048,  United States; Recruiting
Moshe Arditi, MD  310-423-4471 

      Santa Barbara Cottage Hospital, Santa Barbara,  California,  93102,  United States; Recruiting
Felicity Hodder, MD  805-682-7111 

      Southern California Permanente Medical Group, Downey,  California,  90242,  United States; Recruiting
Willye B. Powell, MD  562-803-2472 

      Sutter Cancer Center, Sacramento,  California,  95816,  United States; Recruiting
Yisheng Lee, MD, PhD, MBA  916-733-1757 

      UCSF Comprehensive Cancer Center, San Francisco,  California,  94143,  United States; Recruiting
Katherine K. Matthay, MD  415-476-3831 

      Children's Hospital Cancer Center, Denver,  Colorado,  80218,  United States; Recruiting
Roger Howard Giller, MD  303-861-6892 

      Presbyterian - St. Luke's Medical Center, Denver,  Colorado,  80218,  United States; Recruiting
Stephen R. Palmer, MD  719-471-2462 

      Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington,  Connecticut,  06360-7106,  United States; Recruiting
Arnold J. Altman, MD  860-545-9630 

      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8064,  United States; Recruiting
Jack van Hoff, MD  203-785-4640 

      Alfred I. duPont Hospital for Children, Wilmington,  Delaware,  19899,  United States; Recruiting
Rita S. Meek, MD  302-651-5502 

District of Columbia
      Children's National Medical Center, Washington,  District of Columbia,  20010-2970,  United States; Recruiting
Nita Louise Seibel, MD  202-884-2144 

      Lombardi Cancer Center at Georgetown University Medical Center, Washington,  District of Columbia,  20007,  United States; Recruiting
Aziza Shad, MD  202-444-2224 

      All Children's Hospital, St. Petersburg,  Florida,  33701,  United States; Recruiting
Jerry L. Barbosa, MD  727-892-4231 

      Baptist-South Miami Regional Cancer Program, Miami,  Florida,  33176-2197,  United States; Recruiting
Doured Daghistani, MD  786-596-1960 

      Broward General Medical Center, Fort Lauderdale,  Florida,  33316,  United States; Recruiting
Rudolph R. Roskos, MD  954-355-4527 

      Children's Hospital of Southwest Florida, Fort Myers,  Florida,  33908,  United States; Recruiting
Emad K. Salman, MD  239-432-3333 

      Florida Hospital Cancer Institute, Orlando,  Florida,  32804,  United States; Recruiting
Jane Crofton, RN, BSN, OCN  407-303-2090 

      Jackson Memorial Hospital, Miami,  Florida,  33136,  United States; Recruiting
Stuart R. Toledano, MD  305-585-5635 

      Joe DiMaggio Children's Hospital at Memorial, Hollywood,  Florida,  33021,  United States; Recruiting
Iftikhar Hanif, MD  954-986-2234 

      Miami Children's Hospital, Miami,  Florida,  33155,  United States; Recruiting
Enrique A. Escalon, MD  305-666-6511 

      Nemours Children's Clinic, Jacksonville,  Florida,  32207,  United States; Recruiting
Eric Sandler, MD  904-390-3793 

      Nemours Children's Clinic-Orlando, Orlando,  Florida,  32806,  United States; Recruiting
Vincent F. Giusti, MD  407-650-7230 

      Sacred Heart Children's Hospital, Pensacola,  Florida,  32504,  United States; Recruiting
John F. Kelleher, MD  850-505-4798 

      St. Joseph's Children's Hospital, Tampa,  Florida,  33677-4227,  United States; Recruiting
Cameron K. Tebbi, MD  813-870-4252 

      St. Mary's Hospital, West Palm Beach,  Florida,  33407,  United States; Recruiting
Narayana Gowda, MD  561-840-6125 

      University of Florida Shands Cancer Center, Gainesville,  Florida,  32610-0296,  United States; Recruiting
Stephen P. Hunger, MD  352-392-5633 

      AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta,  Georgia,  30342,  United States; Recruiting
Howard M. Katzenstein, MD  404-785-0853 

      Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah,  Georgia,  31405,  United States; Recruiting
Tribhawan S. Vats, MD  912-350-8194 

      MBCCOP-Medical College of Georgia Cancer Center, Augusta,  Georgia,  30912-4000,  United States; Recruiting
Roger A. Vega, MD  706-721-3626 

      Medical Center of Central Georgia, Macon,  Georgia,  31201,  United States; Recruiting
Hassan Dannawi, MD  478-633-1104 

      Cancer Research Center of Hawaii, Honolulu,  Hawaii,  96813,  United States; Recruiting
Robert Warren Wilkinson, MD  808-586-2979 

      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States; Recruiting
Brian F. Issell, MD  808-586-3015 

      Tripler Army Medical Center, Honolulu,  Hawaii,  96859-5000,  United States; Recruiting
Braden Alan Shoupe, MD  808-433-6057 

      Mountain States Tumor Institute - Boise, Boise,  Idaho,  83712,  United States; Recruiting
J. Martin Johnston, MD  208-381-2782 

      Advocate Hope Children's Hospital, Oak Lawn,  Illinois,  60453,  United States; Recruiting
Sharad N. Salvi, MD  708-346-4094 

      Children's Memorial Hospital - Chicago, Chicago,  Illinois,  60614,  United States; Recruiting
Susan Lerner Cohn, MD  773-880-4562 

      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068-1174,  United States; Recruiting
Jong-Hyo Kwon, MD  847-723-5962 

      Rush University Medical Center, Chicago,  Illinois,  60612,  United States; Recruiting
Allen D. Korenblit, MD  312-942-5983 

      Saint Jude Midwest Affiliate, Peoria,  Illinois,  61637,  United States; Recruiting
John A. McCallister, MD  309-624-4945 

      Southern Illinois University School of Medicine, Springfield,  Illinois,  62794-9658,  United States; Recruiting
Gregory Brandt, MD  217-545-5817 

      University of Chicago Cancer Research Center, Chicago,  Illinois,  60601,  United States; Recruiting
James B. Nachman, MD  773-702-6808 

      University of Illinois Medical Center, Chicago,  Illinois,  60612,  United States; Recruiting
Mary Lou Schmidt, MD  312-996-6143 

      Riley Children Cancer Center at Riley Hospital for Children, Indianapolis,  Indiana,  46202-5225,  United States; Recruiting
Robert Fallon, MD, PhD  317-274-8784 

      St. Vincent Hospitals and Health Care Centers, Indianapolis,  Indiana,  46260,  United States; Recruiting
Randy Alan Hock, MD, PhD, MMM  317-338-4673 

      Blank Children's Hospital, Des Moines,  Iowa,  50308,  United States; Recruiting
Torrey Leighton Mitchell, MD  515-241-8912 

      Holden Comprehensive Cancer Center at University of Iowa, Iowa City,  Iowa,  52242-1009,  United States; Recruiting
Raymond Tannous, MD  319-356-1905 

      John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines,  Iowa,  50309,  United States; Recruiting
Stephen C. Elliott, DO, PhD, FAAP  515-241-6000 

      Wesley Medical Center, Wichita,  Kansas,  67214,  United States; Recruiting
David Rosen, MD  316-962-2025 

      Kosair Children's Hospital, Louisville,  Kentucky,  40202-3830,  United States; Recruiting
Salvatore J. Bertolone, MD  502-852-8450 

      Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington,  Kentucky,  40536-0284,  United States; Recruiting
Martha F. Greenwood, MD  859-323-6771 

      Children's Hospital of New Orleans, New Orleans,  Louisiana,  70118,  United States; Recruiting
Lolie Chua Yu, MD  504-896-9740 

      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States; Recruiting
Jill Gilbert, MD  504-568-5613 

      Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans,  Louisiana,  70121,  United States; Recruiting
Marquis Zimri Hodes, MD, PhD  504-842-5230 

      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112,  United States; Recruiting
Marshall A. Schorin, MD  504-988-5412 

      CancerCare of Maine at Eastern Maine Medial Center, Bangor,  Maine,  04401,  United States; Recruiting
Judith B. Allen, MD  207-973-7520 

      Maine Children's Cancer Program, Scarborough,  Maine,  04074-9308,  United States; Recruiting
Craig A. Hurwitz, MD  207-885-7565 

      Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore,  Maryland,  21215,  United States; Recruiting
Joseph Michael Wiley, MD  410-601-5864 

      Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore,  Maryland,  21201-1595,  United States; Recruiting
Neil Jeffrey Grossman, MD  410-328-2808 

      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States; Recruiting
Cindy Schwartz, MD  410-955-7385 

      Walter Reed Army Medical Center, Silver Spring,  Maryland,  20910,  United States; Recruiting
Kip R. Hartman, MD  301-319-9116 

      Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield,  Massachusetts,  01107,  United States; Recruiting
David A. Steele, MD  413-794-9338 

      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02115,  United States; Recruiting
Holcombe Edwin Grier, MD  617-632-3971 

      Floating Hospital for Children, Boston,  Massachusetts,  02111,  United States; Recruiting
Cynthia S. Kretschmar, MD  617-636-5535 

      UMASS Memorial Cancer Center - University Campus, Worcester,  Massachusetts,  01655,  United States; Recruiting
Ghazala Naheed Usmani, MD  508-856-4225 

      Breslin Cancer Center at Ingham Regional Medical Center, Lansing,  Michigan,  48910,  United States; Recruiting
Renuka Gera, MD  517-334-2337 

      Bronson Methodist Hospital, Kalamazoo,  Michigan,  49007-5364,  United States; Recruiting
Leonard August Mattano, MD, PhD  616-341-6350 

      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States; Recruiting
Jeanne Archer, PhD, APN  248-551-8299 

      Children's Hospital of Michigan, Detroit,  Michigan,  48201,  United States; Recruiting
Yaddanapudi Ravindranath, MBBS  313-745-5649 

      DeVos Children's Hospital, Grand Rapids,  Michigan,  49503,  United States; Recruiting
David Robert Freyer, DO  616-391-2086 

      Hurley Medical Center, Flint,  Michigan,  48503,  United States; Recruiting
Susumu Inoue, MD  810-762-7303 

      Josephine Ford Cancer Center at Henry Ford Health System, Detroit,  Michigan,  48202,  United States; Recruiting
Hassan M. Yaish, MD  313-916-3138 

      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0914,  United States; Recruiting
Raymond J. Hutchinson, MD  734-936-8785 

      Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit,  Michigan,  48236,  United States; Recruiting
Hadi Sawaf, MD  313-647-3200 

      William Beaumont Hospital - Royal Oak, Royal Oak,  Michigan,  48073-6769,  United States; Recruiting
Charles A. Main, MD  248-551-0360 

      Children's Hospitals and Clinics - Minneapolis/St. Paul, Minneapolis,  Minnesota,  55404,  United States; Recruiting
Maura C. O'Leary, MD  612-813-5940 

      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905,  United States; Recruiting
Carola A.S. Arndt, MD  507-284-2695 

      St. Mary's - Duluth Clinic Cancer Center, Duluth,  Minnesota,  55805,  United States; Recruiting
Jacquelyn Dawn Wiermaa, MD  218-786-3625 

      University of Mississippi Medical Center, Jackson,  Mississippi,  39216-4505,  United States; Recruiting
Dale Jeanette Pullen, MD  601-984-5220 

      Cardinal Glennon Children's Hospital, Saint Louis,  Missouri,  63104,  United States; Recruiting
William Shay Ferguson, MD  314-577-5638 

      Children's Mercy Hospital, Kansas City,  Missouri,  64108,  United States; Recruiting
Maxine L. Hetherington, MD  816-234-3265 

      St. Louis Children's Hospital, Saint Louis,  Missouri,  63110,  United States; Recruiting
Robert James Hayashi, MD  314-454-4118 

      University of Missouri - Columbia, Columbia,  Missouri,  65203,  United States; Recruiting
Barbara Anne Gruner, MD  573-882-3961 

      Children's Hospital of Omaha, Omaha,  Nebraska,  68114,  United States; Recruiting
Minnie Abromowitch, MD  402-955-3949 

      UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha,  Nebraska,  68198-2168,  United States; Recruiting
Peter F. Coccia, MD  402-559-7257 

      Sunrise Hospital and Medical Center, Las Vegas,  Nevada,  89109,  United States; Recruiting
Jonathan Bernstein, MD  702-732-0971 

New Hampshire
      Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon,  New Hampshire,  03756,  United States; Recruiting
Eric Christian Larsen, MD  603-650-5541 

New Jersey
      Cancer Center at Hackensack University Medical Center, Hackensack,  New Jersey,  07601,  United States; Recruiting
Michael B. Harris, MD  201-996-5437 

      Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick,  New Jersey,  08903,  United States; Recruiting
Richard A. Drachtman, MD  732-235-5437 

      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112-2094,  United States; Recruiting
Peri Kamalakar, MD  973-926-7161 

      St. Joseph's Hospital and Medical Center, Paterson,  New Jersey,  07503,  United States; Recruiting
Mary Ann Bonilla, MD  973-754-3230 

      Valerie Fund Children's Center at Atlantic Health, Summit,  New Jersey,  07901,  United States; Recruiting
Hazem Helmy Mahmoud, MD  973-971-6731 

New Mexico
      University of New Mexico Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131,  United States; Recruiting
Jami Frost, MD  505-272-4461 

New York
      Albert Einstein Cancer Center at Albert Einstein College of Medicine, Bronx,  New York,  10461,  United States; Recruiting
Eva Radel, MD  718-920-7844 

      Brookdale University Hospital and Medical Center, Brooklyn,  New York,  11212,  United States; Recruiting
Kusum Viswanathan, MD  718-240-5904 

      Brooklyn Hospital Center, Brooklyn,  New York,  11201-5493,  United States; Recruiting
Swayamprabha Sadanandan, MD  718-250-6074 

      Cancer Center of Albany Medical Center, Albany,  New York,  12208,  United States; Recruiting
Jennifer M. Pearce, MD  518-262-5513 

      Comprehensive Cancer Center at Maimonides Medical Center, Brooklyn,  New York,  11219,  United States; Recruiting
Ludovico Guarini, MD  718-283-8173 

      Herbert Irving Comprehensive Cancer Center at Columbia University, New York,  New York,  10032,  United States; Recruiting
Linda Granowetter, MD  212-305-8652 

      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States; Recruiting
Barbara Lawrence Asselin, MD  716-275-2981 

      Long Island Cancer Center at Stony Brook University Hospital, Stony Brook,  New York,  11794,  United States; Recruiting
Robert Ingalls Parker, DSc  631-444-4000 

      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States; Recruiting
Peter G. Steinherz, MD  212-639-7951 

      Mount Sinai School of Medicine, New York,  New York,  10029,  United States; Recruiting
Elizabeth Raetz, MD  212-241-7022 

      New York Medical College, Valhalla,  New York,  10595,  United States; Recruiting
M. Fevzi Ozkaynak, MD  914-493-7997 

      New York Weill Cornell Cancer Center at Cornell University, New York,  New York,  10021,  United States; Recruiting
Patricia J.V. Giardina, MD  212-746-3400 

      Schneider Children's Hospital, New Hyde Park,  New York,  11042,  United States; Recruiting
Arlene Sara Redner, MD  718-470-3460 

      SUNY Downstate Medical Center, Brooklyn,  New York,  11203,  United States; Recruiting
Sreedhar P. Rao, MD  718-270-1693 

      SUNY Upstate Medical University Hospital, Syracuse,  New York,  13210,  United States; Recruiting
Ronald L. Dubowy, MD  315-464-5294 

North Carolina
      Blumenthal Cancer Center at Carolinas Medical Center, Charlotte,  North Carolina,  28232-2861,  United States; Recruiting
Daniel P. McMahon, MD  704-355-1130 

      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1081,  United States; Recruiting
Thomas Williams McLean, MD  336-716-4324 

      Duke Comprehensive Cancer Center, Durham,  North Carolina,  27710,  United States; Recruiting
Philip Paul Breitfeld, MD  919-684-3377 

      Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital, Greenville,  North Carolina,  27858-4354,  United States; Recruiting
Charles W. Daeschner, MD  252-744-4676 

      Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill,  North Carolina,  27599,  United States; Recruiting
Stuart Gold, MD  919-966-0985 

      Mission Hospitals, Asheville,  North Carolina,  28801,  United States; Recruiting
Orren Beaty, DO, PhD  823-213-5770 

      Presbyterian Cancer Center at Presbyterian Hospital, Charlotte,  North Carolina,  28233,  United States; Recruiting
Mark Mogul, MD  704-384-1900 

North Dakota
      Dakota Cancer Institute at Innovis Health - Dakota Clinic, Fargo,  North Dakota,  58103-4940,  United States; Recruiting
Janet K. Tillisch, MD  701-364-4964 

      Children's Hospital Medical Center of Akron, Akron,  Ohio,  44308-1062,  United States; Recruiting
Steven J. Kuerbitz, MD  330-543-8730 

      Children's Medical Center - Dayton, Dayton,  Ohio,  45404,  United States; Recruiting
Emmett H. Broxson, MD, FAAP  937-641-3111 

      Cincinnati Children's Hospital Medical Center, Cincinnati,  Ohio,  45229-3039,  United States; Recruiting
John Peter Perentesis, MD  513-636-6090 

      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195,  United States; Recruiting
Karen A. Bringelsen, MD  216-444-7923 

      Columbus Children's Hospital, Columbus,  Ohio,  43205-2696,  United States; Recruiting
Amanda Termuhlen, MD  614-722-3552 

      Forum Health-Tod Childrens Hospital, Youngstown,  Ohio,  44501,  United States; Recruiting
Ayman Saleh, MD, FAAP  330-884-3955 

      Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland,  Ohio,  44106-5065,  United States; Recruiting
Susan Wiersma, MD  216-844-3345 

      St. Vincent Mercy Medical Center, Toledo,  Ohio,  43608,  United States; Recruiting
Rama Jasty, MD  419-251-8215 

      Toledo Children's Hospital, Toledo,  Ohio,  43601,  United States; Recruiting
Richard M. Shore, MD  419-471-5437 

      CCOP - Oklahoma, Tulsa,  Oklahoma,  74136,  United States; Recruiting
James B. Lockhart, MD  918-491-5878 

      Children's Hospital at Oklahoma University Medical Center, Oklahoma City,  Oklahoma,  73104,  United States; Recruiting
William H. Meyer, MD  405-271-5311 

      Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa,  Oklahoma,  74136,  United States; Recruiting
Martina Christine Hum, MD  918-494-2525 

      CCOP - Columbia River Oncology Program, Portland,  Oregon,  97225,  United States; Recruiting
Keith S. Lanier, MD  503-216-6260 

      Doernbecher Children's Hospital at Oregon Health & Science University, Portland,  Oregon,  97239-3098,  United States; Recruiting
H. Stacy Nicholson, MD, MPH  503-494-1543 

      Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland,  Oregon,  97227,  United States; Recruiting
Janice Faye Olson, MD  503-413-2200 

      Children's Hospital at Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033,  United States; Recruiting
John E. Neely, MD  717-531-6012 

      Children's Hospital of Philadelphia, Philadelphia,  Pennsylvania,  19104,  United States; Recruiting
Richard Berry Womer, MD  215-590-2229 

      Children's Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15213,  United States; Recruiting
Arthur Kim Ritchey, MD  412-692-5055 

      Geisinger Medical Center, Danville,  Pennsylvania,  17822-1320,  United States; Recruiting
Jeffrey Taylor, MD  570-271-6848 

      St. Christopher's Hospital for Children, Philadelphia,  Pennsylvania,  19134-1095,  United States; Recruiting
Gregory E. Halligan, MD  215-427-5000 

Rhode Island
      Rhode Island Hospital, Providence,  Rhode Island,  02903,  United States; Recruiting
Sam W. Lew, MD  401-444-5171 

South Carolina
      Children's Hospital of Greenville Hospital System, Greenville,  South Carolina,  29605,  United States; Recruiting
Cary Ernest Stroud, MD  864-455-8898 

      Hollings Cancer Center at Medical University of South Carolina, Charleston,  South Carolina,  29425-0721,  United States; Recruiting
Julio C. Barredo, MD  843-792-2957 

      Palmetto Health South Carolina Cancer Center, Columbia,  South Carolina,  29203,  United States; Recruiting
Ronnie W. Neuberg, MD  803-434-3533 

South Dakota
      Avera Cancer Institute, Sioux Falls,  South Dakota,  57105-1080,  United States; Recruiting
Marwan D. Hanna, MD  605-322-7595 

      Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls,  South Dakota,  57117-5039,  United States; Recruiting
Jakica Tancabelic, MD  605-333-7171 

      East Tennessee Children's Hospital, Knoxville,  Tennessee,  37901,  United States; Recruiting
Ray C. Pais, MD  865-541-8266 

      East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City,  Tennessee,  37614-0622,  United States; Recruiting
David K. Kalwinsky, MD  423-433-6200    sjcrhta@msha,cin 

      St. Jude Children's Research Hospital, Memphis,  Tennessee,  38105-2794,  United States; Recruiting
Wayne Lee Furman, MD  901-495-3300 

      Vanderbilt Children's Hospital, Nashville,  Tennessee,  37232-6310,  United States; Recruiting
James A. Whitlock, MD  615-936-1762 

      Baylor College of Medicine, Houston,  Texas,  77030,  United States; Recruiting
C. Philip Steuber, MD  713-798-6970 

      CCOP - Scott and White Hospital, Temple,  Texas,  76508,  United States; Recruiting
Lucas Wong, MD  254-724-1053 

      Center for Cancer Prevention and Care at Scott and White Clinic, Temple,  Texas,  76508,  United States; Recruiting
Dick Suh, MD, PhD  254-724-9852 

      Children's Hospital of Austin, Austin,  Texas,  78701,  United States; Recruiting
Sharon K. Lockhart, MD  512-324-8480 

      Cook Children's Medical Center - Fort Worth, Fort Worth,  Texas,  76104,  United States; Recruiting
Timothy C. Griffin, MD  682-885-4020 

      Covenant Children's Hospital, Lubbock,  Texas,  79410,  United States; Recruiting
John Iacuone, MD  806-725-4840 

      MBCCOP - South Texas Pediatrics, San Antonio,  Texas,  78229-3900,  United States; Recruiting
Anne-Marie Langevin, MD  210-704-3405 

      MD Anderson Cancer Center at University of Texas, Houston,  Texas,  77030-4009,  United States; Recruiting
Joann Ater, MD  713-792-6665 

      Medical City Dallas Hospital, Dallas,  Texas,  75230,  United States; Recruiting
Carl Lenarsky, MD  972-566-6647 

      Methodist Cancer Center at Methodist Specialty and Transplant Hospital, San Antonio,  Texas,  78229-3902,  United States; Recruiting
Jaime Estrada, MD  210-575-8130 

      San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base,  Texas,  78236,  United States; Recruiting
Aaron Pitney, MD  210-292-5684 

      Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas,  Texas,  75390-9063,  United States; Recruiting
Naomi J. Winick, MD  214-648-3074 

      Texas Tech University Health Sciences Center School of Medicine, Amarillo,  Texas,  79106,  United States; Recruiting
Curtis Wade Turner, MD  806-354-5434 

      University of Texas Health Science Center at San Antonio, San Antonio,  Texas,  78207,  United States; Recruiting
Paul Jan Thomas, MD  210-704-3405 

      University of Texas Medical Branch, Galveston,  Texas,  77555-0209,  United States; Recruiting
Frederick Szujuei Huang, MD  409-772-2341 

      Huntsman Cancer Institute at University of Utah, Salt Lake City,  Utah,  84112,  United States; Recruiting
Carol S. Bruggers, MD  801-585-0303 

      Vermont Cancer Center at University of Vermont, Burlington,  Vermont,  05401-3498,  United States; Recruiting
Alan C. Homans, MD  802-847-2850 

      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States; Recruiting
Kimberly Dunsmore, MD  434-924-9333 

      Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke,  Virginia,  24029,  United States; Recruiting
Joan Mistretta Fisher, MD, PhD  540-985-8055 

      Children's Hospital of the King's Daughters, Norfolk,  Virginia,  23507,  United States; Recruiting
Rebecca L. Byrd, MD  757-668-7243 

      INOVA Fairfax Hospital, Falls Church,  Virginia,  22042-3300,  United States; Recruiting
Jay N. Greenberg, MD  703-698-1110 

      Massey Cancer Center at Virginia Commonwealth University, Richmond,  Virginia,  23298-0121,  United States; Recruiting
Nancy L. Dunn, MD  804-828-9605&n

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Study ID Numbers:  CDR0000330135; COG-AHOD0121; NCT00070187
Record last reviewed:  December 2004
Last Updated:  March 28, 2005
Record first received:  October 3, 2003 Identifier:  NCT00070187
Health Authority: United States: Federal Government processed this record on 2005-04-08

Cache Date: April 9, 2005


Common Treatments

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