Article: Melphalan

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Melphalan
Systematic (IUPAC) name
 ?
Identifiers
CAS number 148-82-3
ATC code L01AA03
PubChem 4053
DrugBank APRD00118
Chemical data
Formula C13H18Cl2N2O2
Mol. weight 305.2
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

â„ž Prescription only

Routes  ?

Melphalan hydrochloride ( Alkeran®) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. It is used primarily to treat multiple myeloma and ovarian cancer, and occasionally malignant melanoma. Otherwise known as L-Phenylalanine Mustard, or L-PAM, melphalan is a phenylalanine derivative of mechlorethamine. The agent was first investigated as a possible drug for use in melanoma. It did not work, but was found to be of use in myeloma.

Administration

Oral or intravenous; dosing varies by purpose and route of administration as well as patient weight.

Side effects

Common side effects include:

  • Nausea and vomiting
  • Bone marrow suppression, including

Less common side effects include:

  • Severe allergic reactions
  • Scarring of lung tissue (usually only with prolonged use)
  • Hair loss
  • Rash
  • Itching
Chemotherapeutic agents (L01) edit - Chemotherapy regimens
L01A - Alkylating agents: Cyclophosphamide | Chlorambucil | Melphalan | Mechlorethamine | Ifosfamide | Busulfan | ThioTEPA | Lomustine | Streptozocin | Temozolomide | Dacarbazine | Cisplatin | Carboplatin | Oxaliplatin | Procarbazine | Uramustine
L01B - Antimetabolites: Methotrexate | Pemetrexed | Fludarabine Cytarabine | Fluorouracil | Floxuridine | Gemcitabine | Capecitabine
L01C - Plant alkaloids: Vinblastine | Vincristine | Vinorelbine | Etoposide | Paclitaxel | Docetaxel
L01D - Cytotoxic/antitumour antibiotics: Anthracycline family (Doxorubicin | Daunorubicin | Epirubicin | Idarubicin | Mitoxantrone) | Bleomycin | Mitomycin | Hydroxyurea
L01X - Other, including Topoisomerase inhibitors: Topotecan | Irinotecan
Retrieved from "http://en.wikipedia.org/wiki/Melphalan"

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