• The principal scientific objective of the trial is to identify the factors that are associated differential blood pressure response between drugs. This may allow to produce new hypotheses on pathophysiology of hypertension and on the mechanisms of action of drugs

These factors can be of different types :

• Environmental factors (sodium or alcohol intake) • Morphological (height, weight, body mass index, body surface area) • Initial blood pressure • ECG parameters of left ventricular hypertrophy • Biological parameters as the activity level of renin angiotensin aldosterone system • Genetic polymorphisms

Inclusion Criteria:

• Participants have to be 25 to 60 years of age, from both genders, with systolic blood pressure of 140mmHg or above, diastolic blood pressure of 90 mmHg or above.

Their cardiovascular risk must not be high, to allow two periods of 4 weeks of placebo without ethical concern.

Exclusion Criteria:

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