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Sertraline |
Zoloft |
Clinical Trial: Treatment of Cholestatic Pruritus With Sertraline
This study is currently recruiting patients.
Purpose
The goal of this study is to find an effective and well-tolerated medical therapy for itching due to liver disease. Persons with primary biliary cirrhosis or chronic hepatitis C are currently being enrolled in the study. Persons participating in the study are given sertraline, a medication which is also often used for depression,to treat their itching. The dose is gradually increased as the effect on itching and any other potential side effects are carefully monitored.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Pruritus Liver Cirrhosis, Biliary Hepatitis C | Drug: sertraline | Phase II |
MedlinePlus related topics: Bile Duct Diseases; Hepatitis C; Itching
Study Type: Interventional
Study Design: Treatment, Non-Randomized, Open Label, Dose Comparison, Single Group Assignment, Safety/Efficacy Study
Expected Total Enrollment: 40
Study start: April 2003; Expected completion: March 2005
Eligibility
Ages Eligible for Study: 21 Years - 80 Years, Genders Eligible for Study: Both
Criteria
- Itching for at least 3 months
- Primary biliary cirrhosis or hepatitis C
- Elevated alkaline phosphatase for at least 6 months
Location and Contact Information
Texas
University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, 75390, United States; Recruiting
Marlyn J Mayo, MD, Principal Investigator
More Information
Record last reviewed: October 2004
Last Updated: October 14, 2004
Record first received: April 14, 2003
ClinicalTrials.gov Identifier: NCT00058903
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Sertraline (Drug Digest)
- Zoloft (Drug Digest)
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