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Simvastatin |
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Simvastatin Systematic (IUPAC) name [(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6- oxo-oxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a -hexahydronaphthalen-1-yl]2,2-dimethylbutanoate Identifiers CAS number 79902-63-9 ATC code C10AA01 PubChem 54454 DrugBank APRD00104 Chemical data Formula C25H38O5 Mol. weight 418.566 g/mol Pharmacokinetic data Bioavailability 5% Protein binding 95% Metabolism Hepatic (CYP3A4) Half life 3 hours Excretion Renal 13%, faecal ...
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Simvastatin Clinical Trials
- IMPROVE-IT: Examining Outcomes in Subjects with Acute Coronary Syndrome:Vytorin (Ezetimibe/Simvastatin) Vs Simvastatin
ClinicalTrials.gov Identifier: NCT00202878 - Recruiting
Hypercholesterolemia; Myocardial Infarction
- EASEGO-Study - Doubling of Atorvastatin/Simvastatin or INEGY in Pts with Hypercholesterolemia and CAD
ClinicalTrials.gov Identifier: NCT00166530 - Active, not recruiting
Arthersclerosis
- The Effects of Ezetimibe/Simvastatin Tablet 10/20 mg Versus Doubling the Dose of Simvastatin 20 mg [Simvastatin 40 mg] in High Cholesterol and Coronary Heart Disease (Study P04039)
ClinicalTrials.gov Identifier: NCT00423579 - Recruiting
Hypercholesterolemia; Coronary Disease
- Ezetimibe (+) Simvastatin Vs. Atorvastatin Comparative Study in DM or Metabolic Syndrome Patients
ClinicalTrials.gov Identifier: NCT00157924 - Active, not recruiting
Hypercholesterolemia
- An Evaluation of Simvastatin Plus Omacor Compared to Simvastatin Plus Placebo in Subjects With Mixed Dyslipidemia
ClinicalTrials.gov Identifier: NCT00487591 - Active, not recruiting
Mixed Dyslipidemia
- Zolip 0501: Comparison of the Combination of Fenofibrate and 20 mg Simvastatin Versus 40 mg Simvastatin Monotherapy
ClinicalTrials.gov Identifier: NCT00349375 - Recruiting
Hyperlipidemia
- Zolip 0502: Comparison of the Combination of Fenofibrate and 40 mg Simvastatin Versus 40 mg Simvastatin Monotherapy
ClinicalTrials.gov Identifier: NCT00352183 - Recruiting
Cardiovascular Diseases
- Vascular Effects of Ezetimibe/Simvastatin and Simvastatin on Atherosclerosis
ClinicalTrials.gov Identifier: NCT00560170 - Recruiting
Atherosclerosis
- LDL Receptor Under Ezetimibe and Simvastatin
ClinicalTrials.gov Identifier: NCT00317993 - Active, not recruiting
Healthy Men
- Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin
ClinicalTrials.gov Identifier: NCT00362206 - Active, not recruiting
Hyperlipidemia
- Effect of TAK-475 and Simvastatin Alone or in Combination on Blood Cholesterol Levels.
ClinicalTrials.gov Identifier: NCT00286481 - Active, not recruiting
Hyperlipidemia; Hypercholesterolemia
- Efficacy of Fluvastatin and Fenofibrate in Comparison to Simvastatin and Ezetimibe in Patients With Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00385658 - Active, not recruiting
Dyslipidemia
- Study Comparing the Safety and Efficacy of ABT-335 and Simvastatin Combination Therapy to Monotherapy in Subjects With Mixed Dyslipidemia
ClinicalTrials.gov Identifier: NCT00300456 - Active, not recruiting
Dyslipidemias
- Simvastatin as a Treatment for Pulmonary Hypertension
ClinicalTrials.gov Identifier: NCT00180713 - Recruiting
Pulmonary Hypertension
- Combination of Telmisartan and Simvastatin in the Treatment of Hypertension and Hypercholesterolemia
ClinicalTrials.gov Identifier: NCT00316095 - Active, not recruiting
Hypertension; Dyslipidemias
- Effect of TAK-475, When Given With Simvastatin, in Patients Needing to Reduce Their Low-Density Cholesterol (“Bad” Cholesterol).
ClinicalTrials.gov Identifier: NCT00256178 - Active, not recruiting
Hyperlipidemia; Hypercholesterolemia
- Gefitinib With or Without Simvastatin in NSCLC
ClinicalTrials.gov Identifier: NCT00452244 - Recruiting
Lung Cancer
- Simvastatin Treatment of Patients With Acute Optic Neuritis.
ClinicalTrials.gov Identifier: NCT00261326 - Not yet recruiting
Optic Neuritis; Multiple Sclerosis
- Study Evaluating the Efficacy and Safety of Simvastatin Alone Compared With Simvastatin Plus Ezetimibe in Type 2 Diabetic Patients
ClinicalTrials.gov Identifier: NCT00551876 - Completed
Diabetes Mellitus, Type 2
- A Study Comparing Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Patients at Risk for Heart Disease
ClinicalTrials.gov Identifier: NCT00551447 - Completed
Coronary Disease
- A 12 Week Study to Assess the Effectiveness of an Investigational Cholesterol-Lowering Drug in Patients That Have Been Hospitalized for a Possible Heart Problem
ClinicalTrials.gov Identifier: NCT00132717 - Active, not recruiting
Hypercholesterolemia
- Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578AM3)
ClinicalTrials.gov Identifier: NCT00552097 - Completed
Atherosclerosis; Hypercholesterolemia; Hyperlipoproteinemia Type II
- Effect of Simvastatin on CF Airway Inflammation
ClinicalTrials.gov Identifier: NCT00255242 - Recruiting
Cystic Fibrosis
- Irinotecan/Cisplatin Plus Simvastatin in ED-SCLC
ClinicalTrials.gov Identifier: NCT00452634 - Recruiting
Small Cell Lung Cancer
- Cholesterol Lowering Agent to Slow Progression (CLASP) of Alzheimer's Disease Study
ClinicalTrials.gov Identifier: NCT00053599 - Active, not recruiting
Alzheimer Disease
- Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial.
ClinicalTrials.gov Identifier: NCT00396513 - Recruiting
Polycystic Ovary Syndrome
- SHARP: Study of Heart and Renal Protection
ClinicalTrials.gov Identifier: NCT00125593 - Active, not recruiting
Kidney Failure, Chronic
- A Randomized, Double-Blind, Placebo-Controlled Trial of Simvastatin on Subarachnoid Hemorrhage-Induced Vasospasm
ClinicalTrials.gov Identifier: NCT00235963 - Active, not recruiting
Subarachnoid Hemorrhage; Delayed Vasospasm
- Efficacy Study of Oral L-Citrulline in Patients Taking Simvastatin With Peripheral Arterial Disease
ClinicalTrials.gov Identifier: NCT00351286 - Active, not recruiting
Peripheral Arterial Disease; Intermittent Claudication
- A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia
ClinicalTrials.gov Identifier: NCT00171093 - Active, not recruiting
Hypertension; Hypercholesterolemia
- Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients
ClinicalTrials.gov Identifier: NCT00575601 - Recruiting
Polycystic Ovary Syndrome
- Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC
ClinicalTrials.gov Identifier: NCT00313859 - Recruiting
Colorectal Cancer; Metastasis
- Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00531882 - Recruiting
Cystic Fibrosis; Anti Inflammatory Non-Steroidal; Neutrophils
- SEARCH: Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
ClinicalTrials.gov Identifier: NCT00124072 - Active, not recruiting
Cardiovascular Disease
- Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients with Dyslipidemia: A Dose-Ranging Study - SEACOAST
ClinicalTrials.gov Identifier: NCT00082251 - Completed
Hypercholesterolemia
- Ezetimibe (+) Simvastatin Vs. Atorvastatin Comparative Study
ClinicalTrials.gov Identifier: NCT00166504 - Completed
Hypercholesterolemia
- Evaluate the Efficacy and Safety of Rosuvastatin Versus Simvastatin in Type 2 Diabetic Patients With Dyslipidemia
ClinicalTrials.gov Identifier: NCT00506961 - Recruiting
Diabetes Mellitus; Dyslipidemia
- Efficacy And Safety Study Of Atorvastatin Versus Simvastatin In Type 2 Diabetic Subjects With Hypercholesterolemia
ClinicalTrials.gov Identifier: NCT00141141 - Completed
Hypercholesterolemia
- Follow-on Protocol of Pitavastatin Versus Simvastatin in Patients With Hypercholesterolemia or Dyslipidemia and Coronary Heart Disease Risk Factors
ClinicalTrials.gov Identifier: NCT00344175 - Active, not recruiting
Hypercholesterolemia; Dyslipidemia; Coronary Heart Disease
- Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients with Dyslipidemia (OCEANS)
ClinicalTrials.gov Identifier: NCT00080275 - Completed
Hypercholesterolemia
- Study of the Inflammatory Activity in Diabetic Patients With Stable Angina Treated With Simvastatin and Ezetimibe
ClinicalTrials.gov Identifier: NCT00474123 - Recruiting
Diabetes; Stable Angina
- A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis.
ClinicalTrials.gov Identifier: NCT00365001 - Recruiting
Rheumatoid Arthritis
- Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin.
ClinicalTrials.gov Identifier: NCT00404599 - Not yet recruiting
Diabetes Mellitus; Hypertension
- A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
ClinicalTrials.gov Identifier: NCT00384865 - Recruiting
Hypertension, Pulmonary
- Ezetimibe/Simvastatin in Patients With Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00409773 - Recruiting
Hypercholesterolemia; Metabolic Syndrome
- Carotid Plaque Regression With High Dose Atorvastatin Versus Conventional Dose Simvastatin Using High Field MRI
ClinicalTrials.gov Identifier: NCT00388843 - Recruiting
Carotid Atherosclerosis
- An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)
ClinicalTrials.gov Identifier: NCT00465088 - Recruiting
Hyperlipidemia; Mixed Dyslipidemia
- Detection of Plaque Inflammation by Positron Emission Tomography (PET)-Effects of Simvastatin on Plaque Inflammation
ClinicalTrials.gov Identifier: NCT00114504 - Recruiting
Atherosclerosis
- Stop Atherosclerosis in Native Diabetics Study (SANDS)
ClinicalTrials.gov Identifier: NCT00047424 - Active, not recruiting
Atherosclerosis; Cardiovascular Diseases; Heart Diseases; Diabetes Mellitus; Hypertension
- Simvastatin and Anastrozole in Treating Postmenopausal Women With Invasive Breast Cancer, Ductal Carcinoma In Situ, or a High Risk of Breast Cancer
ClinicalTrials.gov Identifier: NCT00354640 - Recruiting
Breast Cancer
- EARLY IFNB-1a and Simvastatin Combination Therapy in Clinically Isolated Syndrome Suggestive of Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00146068 - Recruiting
Multiple Sclerosis
- Simvastatin as an Add-on Treatment to Interferon-Beta-1a for the Treatment of Relapsing-Remitting Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00492765 - Recruiting
Multiple Sclerosis
- A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk
ClinicalTrials.gov Identifier: NCT00479713 - Recruiting
Hypercholesterolemia
- A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol.
ClinicalTrials.gov Identifier: NCT00267254 - Completed
Hyperlipidemia; Dyslipidemia; Hypercholesterolemia
- A Study to Assess the Cholesterol Lowering Effect of Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Elderly Patients With High Cholesterol at High or Moderately High Risk for Coronary Heart Disease
ClinicalTrials.gov Identifier: NCT00535405 - Recruiting
Hypercholesterolemia
- Simvastatin in Patients With Septic Shock
ClinicalTrials.gov Identifier: NCT00450840 - Recruiting
Septic Shock
- Simvastatin (Zocor) Therapy in Sickle Cell Disease
ClinicalTrials.gov Identifier: NCT00508027 - Recruiting
Sickle Cell Disease
- Simvastatin in Preventing a New Breast Cancer in Women Who Are at High Risk for a New Breast Cancer After Undergoing Surgery for Ductal Carcinoma in Situ or Stage I, Stage II, or Stage III Breast Cancer
ClinicalTrials.gov Identifier: NCT00334542 - Recruiting
Breast Cancer
- Simvastatin in Waldenstrom's Macroglobulinemia
ClinicalTrials.gov Identifier: NCT00575965 - Recruiting
Waldenstrom's Macroglobulinemia
- Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
ClinicalTrials.gov Identifier: NCT00064792 - Recruiting
Smith-Lemli-Opitz Syndrome
- Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
ClinicalTrials.gov Identifier: NCT00487461 - Recruiting
Aneurysmal Subarachnoid Hemorrhage; Vasospasm
- Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis
ClinicalTrials.gov Identifier: NCT00291863 - Recruiting
Renal Failure, End Stage; Peritoneal Dialysis
- To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With High Cholesterol.
ClinicalTrials.gov Identifier: NCT00271817 - Recruiting
Hypercholesterolemia
- Simvastatin as an Add-on Treatment to Copaxone for the Treatment of Relapsing Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00429442 - Not yet recruiting
Relapsing Remitting Multiple Sclerosis
- Comparison of the Combination of Fenofibrate and Simvastatin Versus Atorvastatin
ClinicalTrials.gov Identifier: NCT00362934 - Completed
Hyperlipidemia
- Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity
ClinicalTrials.gov Identifier: NCT00546182 - Completed
Hypercholesterolemia
- Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin
ClinicalTrials.gov Identifier: NCT00309738 - Completed
Hypercholesterolemia; Dyslipidemia
- Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin
ClinicalTrials.gov Identifier: NCT00309777 - Completed
Hypercholesterolemia; Dyslipidemia
- A Clinical Trial Comparing Torcetrapib/Atorvastatinto Ezetimibe/Simvastatin In Subjects With A Cholesterol Disorder.
ClinicalTrials.gov Identifier: NCT00267267 - Terminated
Hyperlipidemia; Dyslipidemia
- Evaluation of Efficacy and Safety of Combined Omacor (Omega-3-Acid Ethyl Esters) and Simvastatin Therapy in Hypertriglyceridemic Subjects
ClinicalTrials.gov Identifier: NCT00246701 - Completed
Hypertriglyceridemia
- A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol (A5091031).
ClinicalTrials.gov Identifier: NCT00267280 - Terminated
Hyperlipidemia; Dyslipidemia; Hypercholesterolemia
- Efficacy and Safety of Valsartan and the Combination of Valsartan and Simvastatin
ClinicalTrials.gov Identifier: NCT00385931 - Completed
Hypertension; Hypercholesterolemia; Dyslipidemia
- Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD
ClinicalTrials.gov Identifier: NCT00159835 - Completed
Cardiovascular Diseases
- Evaluation of the Effects of Simvastatin 40mg on Lipid Profiles and Cardiac Function and Structures in Hypercholesterolemia Patients
ClinicalTrials.gov Identifier: NCT00397826 - Completed
Hypercholesterolemia
- To Evaluate the Lipid-Lowering Efficacy and Safety of Simvastatin 40 Mg Tablet In Patients With Hypercholesterolemia
ClinicalTrials.gov Identifier: NCT00398294 - Completed
Hypercholesterolemia
- A Crossover Study to Evaluate the Efficacy of Simvastatin in Elevating HDL-C Levels in Patients With Type 2 Diabetes
ClinicalTrials.gov Identifier: NCT00389896 - Completed
HDL Cholesterol
- Simvastatin as Inhibitor of Cell Adhesion Mediated Drug Resistance in Patients With Refractory Multiple Myeloma.
ClinicalTrials.gov Identifier: NCT00399867 - Completed
Multiple Myeloma
- Transesophageal MRI in Conjunction with Lipid Lowering Measures
ClinicalTrials.gov Identifier: NCT00125060 - Completed
Heart Disease
- PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography
ClinicalTrials.gov Identifier: NCT00259441 - Completed
Kidney Failure
- Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes
ClinicalTrials.gov Identifier: NCT00471549 - Completed
Type 2 Diabetes
- A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet
ClinicalTrials.gov Identifier: NCT00566267 - Completed
Hyperlipidemia
- A Study of Ezetimibe Plus Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia
ClinicalTrials.gov Identifier: NCT00129402 - Completed
Hypercholesterolemia
- A Study to Evaluate the Efficacy of Valsartan/Simvastatin Combinations in Patients With Both Essential Hypertension and Hypercholesterolemia
ClinicalTrials.gov Identifier: NCT00254475 - Completed
Essential Hypertension; Hypercholesterolemia
- A Drug-Drug Interaction Study of GK Activator (2) and Simvastatin in Patients With Type 2 Diabetes.
ClinicalTrials.gov Identifier: NCT00377442 - Completed
Diabetes Mellitus, Type 2
- Study of Drugs for High Blood Pressure and High Cholesterol in American Indians with Type 2 Diabetes at High Risk of Kidney or Heart Disease
ClinicalTrials.gov Identifier: NCT00004266 - Completed
Diabetic Nephropathy
- A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood
ClinicalTrials.gov Identifier: NCT00000941 - Completed
HIV Infections
- Simvastatin Therapy in Women With Polycystic Ovary Syndrome.
ClinicalTrials.gov Identifier: NCT00365638 - Completed
Polycystic Ovary Syndrome
- Ezetimibe and Simvastatin in Dyslipidemia of Diabetes
ClinicalTrials.gov Identifier: NCT00157482 - Completed
Type 2 Diabetes
- The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs
ClinicalTrials.gov Identifier: NCT00017758 - Completed
HIV Infections; HIV Seronegativity; Lipodystrophy
- Comparative Efficacy Evaluation of Lipids when Treated with Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
ClinicalTrials.gov Identifier: NCT00079638 - Completed
Dyslipidemia; Coronary Heart Disease; Atherosclerosis; Stroke; Diabetes
- Ezetimibe and Simvastatin in Primary Hypercholesterolemia, Diabetes Mellitus Type 2, and Coronary Heart Disease (COMPLETED)
ClinicalTrials.gov Identifier: NCT00423488 - Completed
Hypercholesterolemia; Diabetes Mellitus, Type 2; Coronary Disease
- Fast Assessment of Stroke and Transient ischemic attack to prevent Early Recurrence (FASTER)
ClinicalTrials.gov Identifier: NCT00109382 - Completed
Transient Ischemic Attack; Stroke
- HDL-Atherosclerosis Treatment Study (HATS)
ClinicalTrials.gov Identifier: NCT00000553 - Completed
Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia
- A Randomized, Double-Blind, Placebo-Controlled Study to Examine the Effect of Betahistine on Plasma Lipids in Patients Treated With Simvastatin
ClinicalTrials.gov Identifier: NCT00466869 - Terminated
Hypercholesterolemia
Resources
- Simvastatin (Drug Digest)
- Simvastatin (Cleveland Clinic)
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