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Fluoxetine as a Quit Smoking AID for Depression Prone - Article


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Fluoxetine

Prozac; Prozac Weekly; Sarafem 




Clinical Trial: Fluoxetine as a Quit Smoking AID for Depression Prone

This study has been completed.

Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)

Purpose

To test whether adding fluoxetine pharmacotherapy to behavioral cessation treatment improves the depression-prone smoker’s ability to quit.
Condition Intervention
Cardiovascular Diseases
Heart Diseases
 Drug: fluoxetine
 Behavior: cognitive behavioral therapy

MedlinePlus related topics:  Heart Diseases;   Vascular Diseases

Study Type: Interventional
Study Design: Prevention, Double-Blind, Placebo Control

Further Study Details: 

Study start: February 1998;  Study completion: January 2002

DESIGN NARRATIVE: The research was a treatment-matching study to test whether adding fluoxetine pharmacotherapy to behavioral cessation treatment improved the depression-prone smoker''''s ability to quit. The investigators randomized 144 smokers with a prior history of depression and 206 smokers who lack such a history to a double-blind treatment with either 60 mg fluoxetine or placebo, while they underwent cognitive behavioral treatment to quit smoking. The main study outcome was biologically verified abstinence 6 months after treatment. The administration of placebo and fluoxetine began 3 weeks before the quit smoke date and continued for 2 months post-quit date (totaling 11 weeks on drug/placebo). Cognitive behavioral treatment were weekly before quitting and biweekly after quitting. There were monthly follow-up evaluations for six months after the quit date. The research tested both the Selective Benefit Hypothesis and the Generalized Benefit Hypothesis of fluoxetine''''s effects. The hypothesis of the mechanism of action was that the drug diminished compulsive smoking behavior, obsessional cigarette craving, and nicotine withdrawal dysphoria that occurred independently of depressive vulnerability.

Eligibility

Genders Eligible for Study:  Both
Criteria
An estimated 144 smokers with a prior history of depression and 206 smokers who lacked such a history.

Location Information

Study chairs or principal investigators

Bonnie Spring,  U.S. Dept/Vets Affairs Med Ctr.   

More Information

Publications

Hitsman B, Spring B, Wolf W, Pingitore R, Crayton JW, Hedeker D. Effects of acute tryptophan depletion on negative symptoms and smoking topography in nicotine-dependent schizophrenics and nonpsychiatric controls. Neuropsychopharmacology. 2005 Mar;30(3):640-8.

Sanchez-Johnsen LA, Fitzgibbon ML, Ahluwalia JS, Spring BJ. Eating pathology among Black and White smokers. Eat Behav. 2005 Feb;6(2):127-36.

Holmes EW, Russell PM, Kinzler GJ, Reckard CR, Flanigan RC, Thompson KD, Bermes EW Jr. Oxidative tryptophan metabolism in renal allograft recipients: increased kynurenine synthesis is associated with inflammation and OKT3 therapy. Cytokine. 1992 May;4(3):205-13.

Cook JW, Spring B, McChargue DE, Borrelli B, Hitsman B, Niaura R, Keuthen NJ, Kristeller J. Influence of fluoxetine on positive and negative affect in a clinic-based smoking cessation trial. Psychopharmacology (Berl). 2004 Apr;173(1-2):153-9. Epub 2004 Jan 15.

Spring B, Pagoto S, McChargue D, Hedeker D, Werth J. Altered reward value of carbohydrate snacks for female smokers withdrawn from nicotine. Pharmacol Biochem Behav. 2003 Sep;76(2):351-60.

Spring B, Pingitore R, McChargue DE. Reward value of cigarette smoking for comparably heavy smoking schizophrenic, depressed, and nonpatient smokers. Am J Psychiatry. 2003 Feb;160(2):316-22.

Johnsen L, MacKirnan D, Spring B, Pingitore R, Sommerfeld BK. Smoking as subculture? Influence on Hispanic and non-Hispanic White women''''s attitudes toward smoking and obesity. Health Psychol. 2002 May;21(3):279-87.

Hitsman B, Spring B, Borrelli B, Niaura R, Papandonatos GD. Influence of antidepressant pharmacotherapy on behavioral treatment adherence and smoking cessation outcome in a combined treatment involving fluoxetine. Exp Clin Psychopharmacol. 2001 Nov;9(4):355-62.

Richmond M, Spring B, Sommerfeld BK, MeChargue D. Rumination and cigarette smoking: a bad combination for depressive outcomes? J Consult Clin Psychol. 2001 Oct;69(5):836-40.

Borrelli B, Spring B, Niaura R, Kristeller J, Ockene JK, Keuthen NJ. Weight suppression and weight rebound in ex-smokers treated with fluoxetine. J Consult Clin Psychol. 1999 Feb;67(1):124-31.

Study ID Numbers:  183
Record last reviewed:  June 2005
Last Updated:  June 30, 2005
Record first received:  June 9, 2005
ClinicalTrials.gov Identifier:  NCT00113737
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-07-05

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December 4, 2009



Page Updated: October 1, 2005
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