This is a large scale study involving fluoxetine (Prozac) versus a placebo in the treatment of adolescents with alcohol use disorder and major depression. All individuals will receive treatment for 12 weeks with a followup phase lasting 9 months.

Ages Eligible for Study:  15 Years   -   18 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Meets criteria for alcohol use disorder and major depressive disorder.

Exclusion Criteria:

• Meets criteria for bipolar disorder, schizoaffective disorder, or schizophrenia.
• Hyper- or hypothyroidism, significant cardiac, neurologic, or renal impairment, and those with significant liver disease.
• Receiving antipsychotic or antidepressant medication in the month prior to entering the study.
• Use of any illicit substance abuse or dependence other than cannabis abuse (and alcohol abuse).
• History of intravenous drug use.
• Pregnancy, inability or unwillingness to use contraceptive methods.
• Inability to read or understand study forms
• Less than 15 years of age or over 18 years of age will be excluded.