Premarin is a mixture of estrogens isolated from mare's urine (PREgnant MARes' urINe) made by Wyeth Pharmaceuticals. Premarin has been one of the most widely used drugs in the United States of America. Premarin became the form of estrogen most commonly used for hormone replacement therapy. The major forms of estrogen in Premarin are estrone (>50%), equilin (15-25%) and equilenin. The estrogens in Premarin are often called "conjugated equine estrogens" (CEE) because the estrogen molecules ...
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