Not Signed In -
Paroxetine |
Paxil; Paxil CR |
Clinical Trial: Treatment of Depression in Parkinson's Disease Trial
Treatment of Depression in Parkinson’s Disease Trial
This study is currently recruiting patients.
|
Purpose
The goal of this study is to evaluate the effectiveness and safety of two antidepressants--nortriptyline and paroxetine, compared to placebo in patients with Parkinson’s disease and depression.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Parkinson Disease Depression | Drug: nortriptyline Drug: paroxetine | Phase II |
MedlinePlus related topics: Depression; Parkinson's Disease
Genetics Home Reference related topics: Parkinson disease
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Safety/Efficacy Study
Official Title: Treatment of Depression in Patients with Parkinson’s Disease
Expected Total Enrollment: 75
Study start: June 2003
Depression is the most common neuropsychiatric disorder found in patients with Parkinson's disease (PD). It causes immense personal suffering and is associated with increased disability and caregiver burden.
Despite the adverse consequences of depression in patients with PD, there are virtually no empirical data to guide clinical treatment. This study will begin to answer some questions on the treatment of depression by testing a SSRI (selective serotonin reuptake inhibitor) antidepressant, paroxetine, a tricyclic antidepressant, nortriptyline, and placebo in a placebo-controlled trial.
A total of 75 patients with PD will be randomized to each of the three arms in a balanced design.
Eligibility
Ages Eligible for Study: 35 Years - 80 Years, Genders Eligible for Study: Both
Criteria
INCLUSION:
- Parkinson's disease without dementia.
- Depression.
- Males or females.
Location and Contact Information
New Jersey
Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States; Recruiting
Matthew Menza, M.D., Principal Investigator
Matthew Menza, M.D., Principal Investigator, Robert Wood Johnson Medical School
More Information
Record last reviewed: October 2004
Last Updated: October 13, 2004
Record first received: June 12, 2003
ClinicalTrials.gov Identifier: NCT00062738
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Paroxetine (Drug Digest)
- Paxil (Drug Digest)
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