Not Signed In -
Paroxetine |
Paxil; Paxil CR |
Clinical Trial: Serotonin and the Upper Airway in Obstructive Sleep Apnea
This study has been completed.
|
Purpose
The purpose of this study is to determine if a certain medication, alone or combined with another medication, will increase muscle activity in the upper airway in people who do and people who do not have sleep apnea. The medications being studied are paroxetine, a commonly used antidepressant, and 5 hydroxy-tryptophan (5HTP), which also can be used as a dietary supplement without a prescription. Because the effects of paroxetine in previous studies were not very large, we will also study it combined with 5HTP to see if the effect on the upper airway muscles is greater.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Obstructive Sleep Apnea | Drug: Paroxetine Drug: 5HTP | Phase IV |
MedlinePlus related topics: Sleep Apnea
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Study start: November 2000
Eligibility
Ages Eligible for Study: 16 Years - 60 Years, Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
Group A: 20 Adult patients with mild to severe sleep apnea. If patients are being treated with nasal CPAP, they will continue treatment except on study nights.
Group B: 20 normal adult non-snoring subjects.
Location Information
Florida
Malcolm Randall VA Medical Center, Gainesville, Florida, 32608, United States
More Information
Record last reviewed: December 2004
Last Updated: December 30, 2004
Record first received: December 30, 2004
ClinicalTrials.gov Identifier: NCT00100464
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Paroxetine (Drug Digest)
- Paxil (Drug Digest)
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