Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.

Condition	Treatment or Intervention
Hypertension	Drug: Chlorthalidone  Drug: Furosemide

Further Study Details: 

Primary Hypothesis: A variety of clinical questions of major importance can be addressed using clinical data routinely obtained in the VA Hypertension Screening and Treatment Program. For example, treatment of mild hypertension reduces the risk of strokes and heart attacks. Secondary Hypothesis: Target organ damage occurs despite blood pressure control.

Intervention: Chlorthalidone, furosemide, hydrochlorothiazide, metolazone, indapamide, amiloride, spironolactone, triamterene, atenolol, metoprolol, nadolol, pindolol, propranolol, timolol, acebutolol, penbutolol, clonidine, guanethidine, methydopa, prazosin, guanadrel, labetalol, reserpine, guanfacine, hydralazine, minoxidil, captopril, enalapril, lisinopril, diltiazem, nifedipine, verapamil, nicardipine, dyazide, maxzide, pargyline, terazosin, other anti-hypertensives.

Primary Outcomes: Blood Pressure and Target Organ Damage

Study Abstract: Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.

This demonstration project provides for central collection of a standard set of clinical data for patients at some of the Hypertension Screening and Treatment Program clinics, thereby setting up a national data base on the treatment of hypertension. The primary objective of this project is to demonstrate the value of establishing this type of database. The database is being used to estimate the average annual cost of different antihypertensive regimens, to determine the cost-efficacy of different therapies and the least expensive effective therapy and to address some major unanswered clinical questions that require large populations and long-term patient care data. There are currently 13 medical centers participating.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Patients at Hypertension Screening and Treatment Program clinics

California
      Vamc - Sepulveda, Sepulveda,  California,  United States
District of Columbia
      Vamc - Washington, Dc, Washington,  District of Columbia,  United States
Florida
      Vamc - Miami, Miami,  Florida,  United States
Indiana
      Vamc - Indianapolis, Indianapolis,  Indiana,  United States
Iowa
      Vamc - Iowa City, Iowa City,  Iowa,  United States
Mississippi
      Vamc - Jackson, Jackson,  Mississippi,  United States
Ohio
      Vamc - Dayton, Dayton,  Ohio,  United States
Pennsylvania
      Vamc - Philadelphia, Philadelphia,  Pennsylvania,  United States
      Vamc - Pittsburgh, Pittsburgh,  Pennsylvania,  United States
Tennessee
      Vamc - Memphis, Memphis,  Tennessee,  United States
Virginia
      Vamc - Richmond, Richmond,  Virginia,  United States
Puerto Rico
      Vamc - San Juan, Pr, San Juan,  Puerto Rico

Study ID Numbers:  324
Record last reviewed:  February 2003
Last Updated:  October 13, 2004
Record first received:  December 29, 2000
ClinicalTrials.gov Identifier:  NCT00007592
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08