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Divalproex |
Depakote; Depakote ER |
Valproic acid Systematic (IUPAC) name 2-propylpentanoic acid Identifiers CAS number 99-66-1 ATC code N03AG01 PubChem 3121 DrugBank APRD00256 Chemical data Formula C8H16O2 Mol. weight 144.211 g/mol SMILES CCCC(CCC)C(=O)O Pharmacokinetic data Bioavailability Rapid absorption Protein binding concentration dependent from 90% at 40 µg/mL to 81.5% at 130 µg/mL. Metabolism hepatic - glucuronide conjugation 30-50%, mitochondrial β-oxidation over 40% Ha ...
Wikipedia - [full article]
Divalproex Clinical Trials
- A Comparison of Fluoxetine and Divalproex for the Treatment of Intermittent Explosive Disorder (IED)
ClinicalTrials.gov Identifier: NCT00078754 - Recruiting
Intermittent Explosive Disorder
- Effects of Divalproex Sodium on Food Intake, Energy Expenditure, and Posture Allocation
ClinicalTrials.gov Identifier: NCT00287053 - Active, not recruiting
Healthy
- Divalproex Sodium in the Treatment of PTSD (Post-Traumatic Stress Disorder)
ClinicalTrials.gov Identifier: NCT00108576 - Completed
PTSD
- Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
ClinicalTrials.gov Identifier: NCT00194116 - Active, not recruiting
Bipolar Disorder
- Comparison of Immediate vs Gradual Switch to Divalproex in Adults With Intellectual Disability
ClinicalTrials.gov Identifier: NCT00347152 - Recruiting
Epilepsy
- An Evaluation of Divalproex Vs. Olanzapine for Alcohol Abuse Relapse Prevention in Patients With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00221481 - Active, not recruiting
Bipolar Disorder
- Lithium Versus Divalproex for Treating Pediatric Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00221429 - Active, not recruiting
Bipolar Disorder
- Combination Therapy for the Treatment of Bipolar Disorders
ClinicalTrials.gov Identifier: NCT00063362 - Active, not recruiting
Bipolar Disorder
- Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder
ClinicalTrials.gov Identifier: NCT00194129 - Active, not recruiting
Bipolar Disorder
- 3-Week Study to Evaluate Efficacy and Safety of Ziprasidone With Either Lithium or Divalproex in Acutely Manic Subjects
ClinicalTrials.gov Identifier: NCT00312494 - Recruiting
Bipolar Disorder
- Naturalistic Study, Comparison of Divalproex ER and Quetiapine for Adults With Acute Mania or Mixed Episodes
ClinicalTrials.gov Identifier: NCT00397020 - Recruiting
Bipolar Disorder
- Treatment and Outcome of Early Onset Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00048802 - Active, not recruiting
Bipolar Disorder
- Risperidone and Divalproex Sodium With MRI Assessment in Pediatric Bipolar
ClinicalTrials.gov Identifier: NCT00176202 - Recruiting
Bipolar Disorder
- Divalproex Sodium ER in Adult Autism
ClinicalTrials.gov Identifier: NCT00211796 - Recruiting
Autism
- Divalproex vs. Lamotrigine for Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00451542 - Active, not recruiting
Bipolar Disorder
- Olanzapine Compared to Divalproex and Placebo in the Treatment of Mild to Moderate Mania Associated with Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00094549 - Completed
Bipolar Disorder
- Effects of Lithium and Divalproex`on Brain-Derived Neurotrophic Factor in Huntington's Disease
ClinicalTrials.gov Identifier: NCT00095355 - Completed
Huntington's Disease
- Effectiveness of Divalproex Sodium (Depakote) in Treating Disruptive Behavior Disorder and Explosive Tempers in Adolescents and Adults
ClinicalTrials.gov Identifier: NCT00218114 - Recruiting
Attention Deficit and Disruptive Behavior Disorders; Marijuana Abuse
- Effect of Lithium and Divalproex in Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00088387 - Completed
Alzheimer Disease
- Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?
ClinicalTrials.gov Identifier: NCT00306475 - Recruiting
Schizophrenia; Schizoaffective Disorder
- Quetiapine SR and Divalproex Sodium ER in the Treatment of Anxiety in Bipolar Disorder With Panic Disorder and/or GAD
ClinicalTrials.gov Identifier: NCT00579280 - Recruiting
Bipolar Disorder; Panic Disorder; Generalized Anxiety Disorder
- Compliance With Once-Daily Divalproex Extended-Release Tablets (Depakote-ER) Versus Multiple-Daily Dose Valproic Acid Capsules (Depakene) in Epilepsy:
ClinicalTrials.gov Identifier: NCT00356018 - Not yet recruiting
Epilepsy
- Study of Divalproex Extended Release Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomania or Mild Mania
ClinicalTrials.gov Identifier: NCT00278772 - Recruiting
Bipolar Spectrum Disorder With Moderate-to- Severe Hypomania or Mild Mania
- Maintenance Phase Treatment With Divalproex for Post Traumatic Stress Disorder
ClinicalTrials.gov Identifier: NCT00203385 - Completed
PTSD
- Divalproex Sodium Vs. Placebo in Childhood/Adolescent Autism
ClinicalTrials.gov Identifier: NCT00211757 - Completed
Autism
- The Safety and Efficacy of Divalproex Sodium Extended-Release Tablets in Migraine Prophylaxis: A Study in Adolescents
ClinicalTrials.gov Identifier: NCT00195741 - Completed
Migraine
- Effectiveness of Divalproex Sodium (Depakote) in Treating Children With Temper Outbursts and Severe Mood Swings
ClinicalTrials.gov Identifier: NCT00217932 - Completed
Mood Disorders
- Treatment of Partial Seizures in Children
ClinicalTrials.gov Identifier: NCT00102713 - Completed
Epilepsies, Partial
- Depakote Monotherapy, Olanzapine Monotherapy, and Combination Therapy of Depakote Plus Olanzapine in Stable Subjects during the Maintenance Phase of Bipolar Illness
ClinicalTrials.gov Identifier: NCT00071253 - Terminated
Bipolar Disorder
- An Inpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00060905 - Completed
Bipolar Disorder
- Divalproex ER vs. Risperidone for Bipolar Disorder With Comorbid Substance Use Disorder
ClinicalTrials.gov Identifier: NCT00203528 - Completed
Substance Abuse; Bipolar Depression
- An Outpatient Study of the Effectiveness and Safety of Depakote ER in the Treatment of Mania/Bipolar Disorder in Children and Adolescents
ClinicalTrials.gov Identifier: NCT00067262 - Completed
Bipolar Disorder
- Depakote ER plus an atypical antipsychotic vs. an atypical antipsychotic alone in the treatment of schizophrenia
ClinicalTrials.gov Identifier: NCT00073164 - Completed
Schizophrenia
- Seroquel plus Mood Stabilizer Compared to Placebo plus Mood Stabilizer in the Maintenance of Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00081380 - Completed
Bipolar Disorder
- Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients
ClinicalTrials.gov Identifier: NCT00375557 - Terminated
Alzheimer's Disease; Dementia; Behavioral Symptoms
- A Study of the Safety and Efficacy of Depakote Sprinkle Capsules in the Treatment of Partial Seizures in Children
ClinicalTrials.gov Identifier: NCT00067431 - Terminated
Partial Seizure Disorder
Resources
- Depakote (Drug Digest)
- Depakote ER (Drug Digest)
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