Not Signed In -
Losartan |
Cozaar |
Losartan Systematic (IUPAC) name (1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)- 2-butyl-4-chloro-1H-imidazol-5-yl)methanol Identifiers CAS number 114798-26-4 ATC code C09CA01 PubChem 3961 DrugBank APRD00052 Chemical data Formula C22H23ClN6O Mol. weight 422.91 Pharmacokinetic data Bioavailability 25–35% Metabolism Hepatic (CYP2C9, CYP3A4) Half life 1.5–2 hours Excretion Renal 13–25%, biliary 50–60% Therapeutic considerations Pregnancy cat. D ...
Wikipedia - [full article]
Losartan Clinical Trials
- Losartan and HCTZ and Amlopidine Vs Atenolol and Amlodipine
ClinicalTrials.gov Identifier: NCT00140959 - Active, not recruiting
Hypertension
- PPARgamma Activation by Losartan in Hypertensive Patients: The Importance of Losartan-Metabolites
ClinicalTrials.gov Identifier: NCT00561327 - Recruiting
Hypertension
- A Study to Evaluate the Renal Protective Effects of Losartan in Patients with Renal Transplant.
ClinicalTrials.gov Identifier: NCT00140907 - Active, not recruiting
Renal Disorder
- Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases
ClinicalTrials.gov Identifier: NCT00140985 - Active, not recruiting
Renal disorder
- Study Comparing SPP100 (Aliskiren) 150mg to Placebo and to Losartan 50mg in Patients With Mild to Moderate Essential Hypertension
ClinicalTrials.gov Identifier: NCT00344110 - Active, not recruiting
Hypertension
- Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients
ClinicalTrials.gov Identifier: NCT00533858 - Recruiting
Hypertension
- Effect of Losartan on Retinal Endothelial Function in Patients with Essential Hypertension
ClinicalTrials.gov Identifier: NCT00152633 - Completed
Hypertension
- Renin Angiotensin System Study (RASS/B-RASS)
ClinicalTrials.gov Identifier: NCT00143949 - Active, not recruiting
Type 1 Diabetes
- Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
ClinicalTrials.gov Identifier: NCT00565396 - Active, not recruiting
Chronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
- Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
ClinicalTrials.gov Identifier: NCT00446563 - Active, not recruiting
Hypertension; Hypertrophy, Left Ventricular
- Losartan Anti-Atherosclerosis Study
ClinicalTrials.gov Identifier: NCT00496834 - Not yet recruiting
Hypertension
- A Prospective, Randomised, Double-Blind, Double-Dummy, Forced-Titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nep
ClinicalTrials.gov Identifier: NCT00168857 - Active, not recruiting
Hypertension; Diabetic Nephropathies
- Kallikrein-Kinin (KKS) and Renin-Angiotension-Aldosterone System (RAAS)in Primary Aldosteronism
ClinicalTrials.gov Identifier: NCT00155064 - Recruiting
Hyperaldosteronism
- Losartan vs. Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
ClinicalTrials.gov Identifier: NCT00388388 - Recruiting
Pre-Hypertension; Pre-Diabetes
- Hydrochlorothiazide (+) Losartan Potassium Vs. Amlodipine Comparative Study
ClinicalTrials.gov Identifier: NCT00157963 - Completed
Essential Hypertension
- Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus
ClinicalTrials.gov Identifier: NCT00419835 - Recruiting
Macroalbuminuric Diabetic Nephropathy
- Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension
ClinicalTrials.gov Identifier: NCT00219141 - Completed
Hypertension; Left Ventricular Hypertrophy; Overweight
- Angiotensin II Blockade
ClinicalTrials.gov Identifier: NCT00067990 - Recruiting
Kidney Disease; Proteinuria
- Study to Determine the Effects of Losartan on Proteinuria in Pediatric Patients
ClinicalTrials.gov Identifier: NCT00568178 - Not yet recruiting
Proteinuria
- A Study of Losartan Compared to Losartan/HCTZ in Pediatric Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00447603 - Terminated
Hypertension
- Effectiveness of Losartan 50 mg/HCTZ 12.5 mg Versus Valsartan 80 mg/HCTZ 12.5 mg Titrated as Needed in Patients With Hypertension Not Controlled on Monotherapy
ClinicalTrials.gov Identifier: NCT00546754 - Recruiting
Hypertension
- Long Term Effects of Enalapril and Losartan on Genetic Heart Disease
ClinicalTrials.gov Identifier: NCT00001534 - Completed
Hypertrophic Cardiomyopathy; Left Ventricular Hypertrophy; Myocardial Ischemia
- A Randomized, Double-Blind, Parallel-Group Assessment of the Safety and Efficacy of Telmisartan 40mg Plus Hydrochlorothiazide 12.5mg (Micardis Plus) in Comparison with Losartan 50mg Plus Hydrochlorothiazide 12.5mg in Taiwanese Patients with Mild to Modera
ClinicalTrials.gov Identifier: NCT00133185 - Completed
Hypertension
- An Open Label Study to Assess the Efficacy, Safety and Tolerability of COZAAR Plus (Losartan Potassium 50mg/Hydrochlorothiazide 12.5mg) Possibly Titrated up to COZAAR Plus-F (Losartan Potassium 100mg/Hydrochlorothiazide 25mg) in Patients With Essential Hy
ClinicalTrials.gov Identifier: NCT00449111 - Terminated
Hypertension
- Glucose Optimisation With Angiotensin II Antagonist Losartan (GOAAL)
ClinicalTrials.gov Identifier: NCT00237588 - Completed
Hypertension
- Pioglitazone and Losartan Provides Additional Renoprotection
ClinicalTrials.gov Identifier: NCT00364988 - Completed
Type 2 Diabetes; Diabetic Nephropathy
- Telmisartan and Losartan in Hypertensive IGT
ClinicalTrials.gov Identifier: NCT00407862 - Completed
Hypertension; Impaired Glucose Tolerance
- A Research Study to Evaluate the Renal (Kidney) Protective Effects of Losartan in Patients With Non-Insulin Dependent Diabetes
ClinicalTrials.gov Identifier: NCT00308347 - Completed
Type 2 Diabetes and Nephropathy
- Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
ClinicalTrials.gov Identifier: NCT00338260 - Completed
Hypertension and Left Ventricular Hypertrophy (Thickening of the Main Pumping Chamber of the Heart)
- A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
ClinicalTrials.gov Identifier: NCT00185094 - Completed
Hypertension; Insulin Resistance; Metabolic Syndrome
- Study of Inherited Changes of Receptors Located on Blood Vessels
ClinicalTrials.gov Identifier: NCT00001741 - Completed
Cardiovascular Disease
- A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00546052 - Completed
Hypertension; Metabolic Disorder
- Effects of Losartan on Hepatic Fibrogenesis in Chronic Hepatitis C
ClinicalTrials.gov Identifier: NCT00298714 - Completed
Chronic Hepatitis C; Liver Fibrosis
- PROBE Parallel 6-wk Treatment Comparing Telmisartan/HCT (40/12.5 or 80/12.5) With Losartan/HCT (50/12.5) Using ABPM
ClinicalTrials.gov Identifier: NCT00274638 - Completed
Hypertension
- Study to Evaluate the Efficacy and Safety of Daglutril Compared to Placebo on Top of Losartan in Type 2 Diabetics with Overt Nephropathy and Well Controlled Hypertension
ClinicalTrials.gov Identifier: NCT00160225 - Completed
Hypertension
- Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy
ClinicalTrials.gov Identifier: NCT00361023 - Completed
Type 2 Diabetes; Diabetic Nephropathy
- Losartan Therapy in Pulmonary Hypertension
ClinicalTrials.gov Identifier: NCT00519870 - Completed
Pulmonary Hypertension
- Olmesartan Medoxomil in Hypertension and Renal Impairment
ClinicalTrials.gov Identifier: NCT00151827 - Completed
Essential Hypertension; Renal impairment
- Long-Term Renoprotection of Optimal Antiproteinuric Doses of Benazepril and Losartan in Chronic Renal Insufficiency
ClinicalTrials.gov Identifier: NCT00338091 - Terminated
Renal Insufficiency,Chronic; Disease Progression; Proteinuria; Dose-Response Relationship,Drug; ACE Inhibitor; Angiotensin II Type 1 Receptor Blockers
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