To evaluate the effects of two different antihypertensive medications in the drug class of beta-blockers on control of glucose in Type II diabetic patients with high blood pressure.

Condition	Treatment or Intervention	Phase
Non-Insulin-Dependent Diabetes Mellitus Hypertension	Drug: carvedilol	Phase IV

Ages Eligible for Study:  30 Years   -   80 Years,  Genders Eligible for Study:  Both

Criteria

• Patients at screening must be insulin producing Type II diabetics (C peptide positive).
• Must have a history of mild to moderate hyperension (140-179 systolic; 90-1-9 diastolic).
• Must be on stable regimen of ACE (angiotensin converting enzyme) / ARB (angiotensin receptor blocker) treatment alone or in combination with other treatments.
• Patient's laboratory result for HbA1c must be 6.5 - 8.5 (drug treated) or 6.5 - 7.5 (diet alone).
• Must be on a stable antidiabetic regimen (drug treated or diet alone).
• Patients cannot currently be using beta-blocker therapy

Arizona
      Study Site 493, Phoenix,  Arizona,  85006,  United States
      Study Site 427, Phoenix,  Arizona,  85012,  United States
      Study Site 473, Phoenix,  Arizona,  85014,  United States
      Study Site 546, Gilbert,  Arizona,  85233,  United States
      Study Site 433, Tucson,  Arizona,  85712,  United States
      Study Site 445, Tucson,  Arizona,  85719,  United States
      Study Site 521, Tucson,  Arizona,  85724,  United States
      Study Site 526, Tucson,  Arizona,  85741,  United States
California
      Study Site 454, Los Angeles,  California,  90057,  United States
      Study Site 484, Pasadena,  California,  91105,  United States
      Study Site 455, Spring Valley,  California,  91978,  United States
      Study Site 503, Encinitas,  California,  92024,  United States
      Study Site 555, Hemet,  California,  92543,  United States
      Study Site 485, Fountain Valley,  California,  92708,  United States
      Study Site 476, Irvine,  California,  92718,  United States
      Study Site 504, Anaheim,  California,  92801,  United States
      Study Site 465, Orange,  California,  92868,  United States
      Study Site 540, San Luis Obispo,  California,  93405,  United States
      Study Site 502, Burlingame,  California,  94010,  United States
      Study Site 474, Stanford,  California,  94305,  United States
      Study Site 446, Concord,  California,  94520,  United States
      Study Site 548, Carmichael,  California,  95608,  United States
Colorado
      Study Site 442, Arvada,  Colorado,  80002,  United States
      Study Site 429, Denver,  Colorado,  80211,  United States
      Study Site 494, Denver,  Colorado,  80218,  United States
      Study Site 472, Denver,  Colorado,  80220,  United States
      Study Site 519, Loveland,  Colorado,  80538,  United States
Florida
      Study Site 549, Panama City,  Florida,  32401,  United States
      Study Site 553, St. Petersburg,  Florida,  33701,  United States
Idaho
      Study Site 537, Idaho Falls,  Idaho,  83404,  United States
      Study Site 525, Hayden Lake,  Idaho,  83835,  United States
Illinois
      Study Site 516, Melrose Park,  Illinois,  60160,  United States
      Study Site 487, Chicago,  Illinois,  60607,  United States
      Study Site 550, O Fallon,  Illinois,  62269,  United States
Indiana
      Study Site 491, Indianapolis,  Indiana,  46260,  United States
      Study Site 457, Elkhart,  Indiana,  46515,  United States
      Study Site 488, Evansville,  Indiana,  47713,  United States
Iowa
      Study Site 529, Des Moines,  Iowa,  50314,  United States
      Study Site 467, Des Moines,  Iowa,  50314,  United States
      Study Site 482, Iowa City,  Iowa,  52242,  United States
Michigan
      Study Site 486, Ann Arbor,  Michigan,  43108,  United States
      Study Site 471, Oak Park,  Michigan,  48237,  United States
      Study Site 480, Kalamazoo,  Michigan,  49009,  United States
Minnesota
      Study Site 456, Arden Hills,  Minnesota,  55126,  United States
      Study Site 441, Minneapolis,  Minnesota,  55417,  United States
Missouri
      Study Site 462, St. Louis,  Missouri,  63104,  United States
      Study Site 460, St. Louis,  Missouri,  63110,  United States
      Study Site 542, St. Louis,  Missouri,  63128,  United States
      Study Site 425, St. Peters,  Missouri,  63376,  United States
      Study Site 544, Kansas City,  Missouri,  64106,  United States
      Study Site 424, Springfield,  Missouri,  65807,  United States
Nebraska
      Study Site 496, Omaha,  Nebraska,  68131,  United States
Nevada
      Study Site 490, Las Vegas,  Nevada,  89014,  United States
      Study Site 530, Las Vegas,  Nevada,  89103,  United States
New Mexico
      Study Site 517, Albuquerque,  New Mexico,  87112,  United States
North Dakota
      Study Site 534, Wishek,  North Dakota,  58495,  United States
Oregon
      Study Site 492, Tualatin,  Oregon,  97062,  United States
South Carolina
      Study Site 538, Bamberg,  South Carolina,  29003,  United States
Texas
      Study Site 501, The Colony,  Texas,  75056,  United States
      Study Site 477, Dallas,  Texas,  75230,  United States
      Study Site 470, Dallas,  Texas,  75235,  United States
      Study Site 554, Arlington,  Texas,  76017,  United States
      Study Site 535, Fort Worth,  Texas,  76104,  United States
      Study Site 423, Houston,  Texas,  77055,  United States
      Study Site 443, Galveston,  Texas,  77555,  United States
      Study Site 475, San Antonio,  Texas,  78221,  United States
      Study Site 459, San Antonio,  Texas,  78229,  United States
      Study Site 483, San Antonio,  Texas,  78229,  United States
      Study Site 522, San Antonio,  Texas,  78229,  United States
      Study Site 463, Austin,  Texas,  78758,  United States
      Study Site 547, Midland,  Texas,  79705,  United States
Utah
      Study Site 497, Ogden,  Utah,  84403,  United States
Washington
      Study Site 422, Kirkland,  Washington,  98034,  United States
      Study Site 449, Renton,  Washington,  98055,  United States
      Study Site 541, Burien,  Washington,  98166,  United States
      Study Site 481, Lakewood,  Washington,  98499,  United States
Wisconsin
      Study Site 509, Milwaukee,  Wisconsin,  53215,  United States
      Study Site 515, Madison,  Wisconsin,  53717,  United States

Study ID Numbers:  105517/346
Record last reviewed:  July 2004
Last Updated:  October 13, 2004
Record first received:  May 15, 2003
ClinicalTrials.gov Identifier:  NCT00060918
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08