Evaluation of the differential effect of two different antihypertensive treatments on control of glucose in Type II diabetic patients with high blood pressure

Condition	Treatment or Intervention	Phase
Non-Insulin-Dependent Diabetes Mellitus Hypertension	Drug: carvedilol	Phase IV

Ages Eligible for Study:  30 Years   -   80 Years,  Genders Eligible for Study:  Both

Criteria

• Patients at screening must be insulin producing Type II diabetics (C peptide positive).
• Patients must have a history of mild to moderate hyperension (140-179 systolic blood pressure; 90-1-9 diastolic blood pressure)
• Patients must be on a stable regimen of ACE (angiotensin converting enzyme) / ARB (angiotensin receptor blocker) treatment alone or in combination with other treatments.
• Patients must be on stable antidiabetic regimen (drug treated or diet alone).
• Patient's laboratory result for HbA1c must be 6.5 - 8.5 (drug treated) or 6.5 - 7.5 (diet alone).
• Patients must not currently be using beta-blocker therapy.

Alabama
      Study Site 197, Columbiana,  Alabama,  35051,  United States
      Study Site 105, Birmingham,  Alabama,  35294,  United States
      Study Site 110, Birmingham,  Alabama,  35294,  United States
Connecticut
      Study Site 181, Farmington,  Connecticut,  06030,  United States
      Study Site 192, Hartford,  Connecticut,  06106,  United States
Delaware
      Study Site 167, Newark,  Delaware,  19713,  United States
District of Columbia
      Study Site 139, Washington,  District of Columbia,  20037,  United States
      Study Site 163, Washington,  District of Columbia,  20422,  United States
Florida
      Study Site 195, Jacksonville,  Florida,  32205,  United States
      Study Site 196, Jacksonville,  Florida,  32216,  United States
      Study Site 233, Gainesville,  Florida,  32605,  United States
      Study Site 241, Melbourne,  Florida,  32901,  United States
      Study Site 248, Hollywood,  Florida,  33021,  United States
      Study Site 228, Hollywood,  Florida,  33023,  United States
      Study Site 127, Pembroke,  Florida,  33024,  United States
      Study Site 201, Miami,  Florida,  33133,  United States
      Study Site 227, Coral Gables,  Florida,  33134,  United States
      Study Site 174, Coral Gables,  Florida,  33134,  United States
      Study Site 153, Miami,  Florida,  33136,  United States
      Study Site 168, Miami,  Florida,  33136,  United States
      Study Site 249, Miami,  Florida,  33176,  United States
      Study Site 130, Fort Lauderdale,  Florida,  33308,  United States
      Study Site 162, Ft. Lauderdale,  Florida,  33308,  United States
      Study Site 251, Fort Lauderdale,  Florida,  33308,  United States
      Study Site 142, Fort Lauderdale,  Florida,  33316,  United States
      Study Site 226, Tamarac,  Florida,  33321,  United States
      Study Site 240, Tampa,  Florida,  33614,  United States
      Study Site 220, Tampa,  Florida,  33614,  United States
      Study Site 256, St. Petersburg,  Florida,  33705,  United States
      Study Site 218, Sarasota,  Florida,  34239,  United States
      Study Site 224, Inverness,  Florida,  34452,  United States
      Study Site 194, Ocala,  Florida,  34471,  United States
      Study Site 255, Hudson,  Florida,  34667,  United States
Georgia
      Study Site 112, Fayetteville,  Georgia,  30214,  United States
      Study Site 213, Augusta,  Georgia,  30901,  United States
      Study Site 250, Savannah,  Georgia,  31406,  United States
Illinois
      Study Site 238, West Evanston,  Illinois,  60202,  United States
      Study Site 211, Chicago,  Illinois,  60616,  United States
Indiana
      Study Site 239, Wabash,  Indiana,  46992,  United States
      Study Site 221, Newburgh,  Indiana,  47630,  United States
Kentucky
      Study Site 171, Lexington,  Kentucky,  40508,  United States
Louisiana
      Study Site 230, New Orleans,  Louisiana,  70112,  United States
      Study Site 216, New Orleans,  Louisiana,  70121,  United States
Maine
      Study Site 187, Auburn,  Maine,  04210,  United States
      Study Site 159, Bangor,  Maine,  04401,  United States
Maryland
      Study Site 154, Baltimore,  Maryland,  21204,  United States
Massachusetts
      Study Site 114, Springfield,  Massachusetts,  01104,  United States
      Study Site 132, Ayer,  Massachusetts,  01432,  United States
      Study Site 104, West Boylston,  Massachusetts,  01583,  United States
      Study Site 152, Salisbury,  Massachusetts,  01952,  United States
      Study Site 109, Waltham,  Massachusetts,  02453,  United States
Michigan
      Study Site 244, Waterford,  Michigan,  48328,  United States
Mississippi
      Study Site 186, Gulfport,  Mississippi,  39501,  United States
New Jersey
      Study Site 207, Magnolia,  New Jersey,  08049,  United States
      Study Site 198, Margate City,  New Jersey,  08402,  United States
New York
      Study Site 121, New York,  New York,  10021,  United States
      Study Site 247, New York,  New York,  10021,  United States
      Study Site 118, New York,  New York,  10032,  United States
      Study Site 253, Bronx,  New York,  10461,  United States
      Study Site 209, Bronx,  New York,  10467,  United States
      Study Site 246, Scarsdale,  New York,  10583,  United States
      Study Site 252, Flushing,  New York,  11365,  United States
      Study Site 212, Kingston,  New York,  12401,  United States
      Study Site 103, Fulton,  New York,  13069,  United States
      Study Site 237, Tonawanda,  New York,  14150,  United States
      Study Site 115, Buffalo,  New York,  14209,  United States
      Study Site 208, Williamsville,  New York,  14221,  United States
      Study Site 177, West Seneca,  New York,  14224,  United States
      Study Site 180, Rochester,  New York,  14609,  United States
North Carolina
      Study Site 149, Winston Salem,  North Carolina,  27103,  United States
      Study Site 145, Raleigh,  North Carolina,  27609,  United States
      Study Site 120, Wilmington,  North Carolina,  28412,  United States
      Study Site 169, Statesville,  North Carolina,  28677,  United States
Ohio
      Study Site 243, Columbus,  Ohio,  43212,  United States
      Study Site 242, Zanesville,  Ohio,  43701,  United States
      Study Site 182, Cleveland,  Ohio,  44106,  United States
      Study Site 179, Canton,  Ohio,  44718,  United States
      Study Site 175, Cincinnati,  Ohio,  45219,  United States
Pennsylvania
      Study Site 234, Connellsville,  Pennsylvania,  15425,  United States
      Study Site 183, Erie,  Pennsylvania,  16506,  United States
      Study Site 222, Philipsburg,  Pennsylvania,  16966,  United States
      Study Site 223, Camp Hill,  Pennsylvania,  17011,  United States
      Study Site 155, Morrisville,  Pennsylvania,  19067,  United States
      Study Site 128, Philadelphia,  Pennsylvania,  19107,  United States
      Study Site 102, Downingtown,  Pennsylvania,  19335,  United States
      Study Site 176, West Grove,  Pennsylvania,  19390,  United States
      Study Site 136, Fleetwood,  Pennsylvania,  19522,  United States
South Carolina
      Study Site 131, Summerville,  South Carolina,  29485,  United States
      Study Site 135, Greer,  South Carolina,  29651,  United States
Tennessee
      Study Site 116, Nashville,  Tennessee,  37212,  United States
      Study Site 156, Bristol,  Tennessee,  37620,  United States
      Study Site 231, Memphis,  Tennessee,  38163,  United States
      Study Site 150, Jackson,  Tennessee,  38301,  United States
Vermont
      Study Site 189, White River Junction,  Vermont,  05009,  United States
Virginia
      Study Site 202, Fredericksburg,  Virginia,  20401,  United States
      Study Site 219, Falls Church,  Virginia,  22044,  United States
      Study Site 160, Springfield,  Virginia,  22151,  United States
      Study Site 170, Richmond,  Virginia,  23220,  United States
      Study Site 190, Christiansburg,  Virginia,  24073,  United States
      Study Site 199, Salem,  Virginia,  24153,  United States

Study ID Numbers:  105517/347
Record last reviewed:  July 2004
Last Updated:  October 13, 2004
Record first received:  May 15, 2003
ClinicalTrials.gov Identifier:  NCT00060931
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08