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Donepezil |
Aricept |
Donepezil Systematic (IUPAC) name 2-[(1-benzyl-4-piperidyl)methyl]- 5,6-dimethoxy-2,3-dihydroinden-1-one Identifiers CAS number 120014-06-4 ATC code N06DA02 PubChem 3152 DrugBank APRD00039 Chemical data Formula C24H29NO3 Mol. weight 379.492 g/mol Pharmacokinetic data Bioavailability 100 (%) Protein binding 96% Metabolism ? Half life 70 hours Excretion 0,11-0,13 (l/h/kg) Therapeutic considerations Pregnancy cat. ? Legal status Routes Ora ...
Wikipedia - [full article]
Donepezil Clinical Trials
- EARTH 413: An Open-Label Study to Evaluate the Effectiveness and Safety of Donepezil Hydrochloride (Aricept) in Hispanic Patients With Mild to Moderate Alzheimer''s Disease (AD)
ClinicalTrials.gov Identifier: NCT00230568 - Active, not recruiting
Alzheimer''s Disease
- Efficacy and Safety of Donepezil in Subjects with Mild Cognitive Impairment
ClinicalTrials.gov Identifier: NCT00100022 - Recruiting
Memory Loss
- Comparison of 23 mg Donepezil Sustained Release (SR) to 10 mg Donepezil Immediate Release (IR) in Patients With Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00478205 - Recruiting
Alzheimer's Disease
- Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome
ClinicalTrials.gov Identifier: NCT00069550 - Recruiting
Rett Syndrome
- Donepezil Treatment of Psychotic Symptoms in Dementia Patients
ClinicalTrials.gov Identifier: NCT00190021 - Not yet recruiting
Dementia of Alzheimer type
- The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)
ClinicalTrials.gov Identifier: NCT00293176 - Active, not recruiting
Memory Loss
- Prevention of Postoperative Delirium with Donepezil
ClinicalTrials.gov Identifier: NCT00220896 - Not yet recruiting
Cognitively normal elderly individuals
- Antidepressant Medication Plus Donepezil for Treating Late-Life Depression
ClinicalTrials.gov Identifier: NCT00177671 - Active, not recruiting
Depression; Dementia
- Drug Treatment for Autism
ClinicalTrials.gov Identifier: NCT00047697 - Active, not recruiting
Autistic Disorder
- Effects of Donepezil on Deficits Associated With Age-Related Decrease of Growth Hormone
ClinicalTrials.gov Identifier: NCT00533065 - Recruiting
Aging
- Donepezil HCl in the Treatment of Subjects with Cognitive Impairment Associated Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
ClinicalTrials.gov Identifier: NCT00103948 - Completed
CADASIL
- CALM-AD
ClinicalTrials.gov Identifier: NCT00142324 - Active, not recruiting
Alzheimer''s Disease
- Memantine Versus Donepezil in Early Stages of Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00505167 - Recruiting
Dementia, Alzheimer Type
- Correlation Between Regional Brain Volume and Response to Donepezil Treatment in AD Patients
ClinicalTrials.gov Identifier: NCT00165750 - Recruiting
Alzheimer's Disease
- Hippocampus Study: Comparative Effect of Donepezil 10mg/d and Placebo on Clinical and Radiological Markers
ClinicalTrials.gov Identifier: NCT00403520 - Recruiting
Alzheimer's Disease
- SB-742457 And Donepezil In Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00348192 - Active, not recruiting
Alzheimer's Disease
- Memory and Mental Health in Aging
ClinicalTrials.gov Identifier: NCT00043589 - Active, not recruiting
Memory Disorders
- Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome
ClinicalTrials.gov Identifier: NCT00570128 - Recruiting
Down Syndrome
- Safety of Donepezil in Patients With Dementia Associated With Cerebrovascular Disease
ClinicalTrials.gov Identifier: NCT00188812 - Active, not recruiting
Dementia Associated With Cerebrovascular Disease
- Donepezil to Treat Dementia in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00030979 - Completed
Parkinson Disease
- An Open Label Study on the Efficacy and Safety of Donepezil Hydrochloride (Aricept) in Vascular Dementia
ClinicalTrials.gov Identifier: NCT00165763 - Recruiting
Vascular Dementia
- Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment
ClinicalTrials.gov Identifier: NCT00530478 - Recruiting
Stroke
- A Multi-Center Study for the Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00381381 - Recruiting
Alzheimer's Disease
- Donepezil and Brain Activity Patterns in Those at Risk For Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00408525 - Recruiting
Alzheimer's Disease
- An Open-Label Trial of Donepezil in Fragile X Syndrome
ClinicalTrials.gov Identifier: NCT00220584 - Recruiting
Fragile X Syndrome
- Use of Donepezil for Treatment of Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00467389 - Recruiting
Cocaine Abuse and Dependence
- Effects of Estrogen on Memory in Post-Menopausal Women and Patients With Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00006399 - Recruiting
Alzheimer Disease
- Improving Memory in Patients with Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00062972 - Recruiting
Multiple Sclerosis
- Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors
ClinicalTrials.gov Identifier: NCT00369785 - Recruiting
Brain and Central Nervous System Tumors; Cognitive/Functional Effects; Fatigue; Psychosocial Effects/Treatment; Radiation Toxicity
- Vaspect Study - An Open-Label Trial Of Donepezil in Vascular and Mixed Dementia
ClinicalTrials.gov Identifier: NCT00174382 - Recruiting
Dementia, Vascular; Dementia, Mixed
- Donepezil Double Blind Trial for ECT Memory Disfunction
ClinicalTrials.gov Identifier: NCT00465283 - Not yet recruiting
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
- Open-Label Extension Study of 23mg Donepezil SR in Patients With Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00566501 - Not yet recruiting
Alzheimer's Disease
- Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
ClinicalTrials.gov Identifier: NCT00452868 - Recruiting
Brain and Central Nervous System Tumors; Cognitive/Functional Effects; Long-Term Effects Secondary to Cancer Therapy in Children; Neurotoxicity; Psychosocial Effects/Treatment; Radiation Toxicity
- Vitamin E and Namenda (Memantine) for the Treatment of Patients With Mild to Moderate Alzheimer''s Disease on Aricept (Donepezil)
ClinicalTrials.gov Identifier: NCT00235716 - Recruiting
Alzheimer''s Disease
- The Effectiveness And Safety Of Donepezil Hydrochloride (E2020) In Subjects With Mild To Severe Alzheimer's Disease Residing In An Assisted Living Facility
ClinicalTrials.gov Identifier: NCT00571064 - Not yet recruiting
Mild to Severe Alzheimer's Disease
- The Effect of Donepezil on Sedation and Other Symptoms
ClinicalTrials.gov Identifier: NCT00352664 - Completed
Advanced Cancer
- Donepezil or EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases
ClinicalTrials.gov Identifier: NCT00070161 - Completed
adult brain tumor; brain metastases; radiation toxicity
- Donepezil in the Prevention of Post-Operative Cognitive Decline
ClinicalTrials.gov Identifier: NCT00182845 - Completed
Postoperative Complications; Delirium
- A Randomized, Placebo-Controlled Trial to Examine the Efficacy of Oral Donepezil in Subjects With MCI
ClinicalTrials.gov Identifier: NCT00483028 - Completed
Alzheimer's Disease
- Donepezil in Chronic Poststroke Aphasia: a Randomized Controlled Trial
ClinicalTrials.gov Identifier: NCT00196690 - Completed
Stroke; Aphasia
- Donepezil Hydrochloride (E2020) in Dementia Associated With Cerebrovascular Disease
ClinicalTrials.gov Identifier: NCT00165737 - Completed
Dementia, Vascular
- Donepezil in Preventing Delirium in Hospitalized Elderly
ClinicalTrials.gov Identifier: NCT00182884 - Completed
Postoperative Complications; Delirium
- The Efficacy, Tolerability and Safety of Donepezil (Aricept®) in Parkinson’s Disease Patients With Dementia
ClinicalTrials.gov Identifier: NCT00165815 - Completed
Dementia With Parkinson's Disease
- Safety of Switching From Donepezil to Rivastigmine Patch in Patients With Probable Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00428389 - Completed
Alzheimer's Disease
- Effects on sleep and attention of two currently marketed drugs for Alzheimer's disease
ClinicalTrials.gov Identifier: NCT00035204 - Completed
Alzheimer's Disease
- Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT00006349 - Completed
extensive stage small cell lung cancer; limited stage small cell lung cancer; Depression; Delirium; Recurrent Small Cell Lung Cancer; ...
- Treatment for Early Memory Loss
ClinicalTrials.gov Identifier: NCT00042172 - Completed
Cognition Disorders; Alzheimer Disease
- Memory Impairment Study (Mild Cognitive Impairment Study)
ClinicalTrials.gov Identifier: NCT00000173 - Completed
Alzheimer Disease
- Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00096473 - Completed
Alzheimer's Disease; Dementia
- Study of the Pathogenesis of Rett Syndrome
ClinicalTrials.gov Identifier: NCT00004807 - Completed
Rett Syndrome
- Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9
ClinicalTrials.gov Identifier: NCT00015132 - Completed
Cocaine-Related Disorders
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