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Genetic Determinants of the Response to Salbutamol Among Asthma Patients - Article


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Albuterol Inhaler

Proventil HFA; Proventil Inhaler; Ventolin Inhaler 



Clinical Trial: Genetic Determinants of the Response to Salbutamol Among Asthma Patients

This study is currently recruiting patients.
Verified by Hadassah Medical Organization August 2004

Sponsored by: Hadassah Medical Organization
Information provided by: Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00162396

Purpose

The response to salbutamol varies greatly among individuals. Data from previous studies indicate that some of the variability is accounted for by genetic polymorphisms in the gene encoding for the adrenoceptor subtype β2. The current study was designed to evaluate variability in the response to salbutamol among recently diagnosed patients who have not been treated by β2 agonists or corticosteroids.

Lung function tests will be performed prior to and following a single dose administration of salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of salbutamol plasma concentration.

Condition Intervention
Asthma
  Drug: Albuterol

MedlinePlus related topics:  Asthma

Study Type: Interventional
Study Design: Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacokinetics/Dynamics Study

Official Title: Evaluation of Genetic Factors That May Account for Variability in the Response to Salbutamol Among Patients Suffering from Asthma

Further Study Details: 
Primary Outcomes: Change in lung function tests after salbutamol inhalation; Change in blood pressure and pulse after salbutamol inhalation
Expected Total Enrollment:  150

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both
Criteria

Inclusion Criteria:

  • 18 years and older
  • Recently diagnosed as asthmatic

Exclusion Criteria:

  • Current treatment by β2 agonist
  • Current treatment by corticosteroids
  • Acute asthma attack

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00162396


Israel
      Hadassah Medical Organization, Jerusalem,  91120,  Israel; Recruiting
Arik Tzukert, DMD  : 00 972 2 6776095    arik@hadassah.org.il 
Hadas Lemberg, PhD  00 972 2 6777572    lhadas@hadassah.org.il 
Yoseph Caraco, MD,  Principal Investigator

Study chairs or principal investigators

Yoseph Caraco, MD,  Principal Investigator,  Hadassah Medical Organization, Jerusalem, Israel   

More Information

Study ID Numbers:  9-10/07/98
Last Updated:  September 12, 2005
Record first received:  September 11, 2005
ClinicalTrials.gov Identifier:  NCT00162396
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
ClinicalTrials.gov processed this record on 2005-09-13


Source: ClinicalTrials.gov
Cache Date: September 14, 2005

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Page Updated: June 1, 2005
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