Trypsinogen (EC is the precursor form of the pancreatic enzyme trypsin. It is activated by enterokinase, which is found in the intestinal mucosa, to form trypsin. Once activated, the tyrpsin can activate more trypsinogen into trypsin.


... Why get tested?
To screen for cystic fibrosis (CF) and pancreatic insufficiency by evaluating pancreatic function.

When to get tested?
When you or your infant have symptoms of pancreatic insufficiency such as persistent diarrhea, foul-smelling bulky greasy stools, malnutrition, and vitamin deficiency. These are also symptoms of cystic fibrosis (CF), so trypsinogen is ordered as part of newborn general population screening and if a newborn has meconium ileus (no stools in the first 24 to 48 hours of life).

Sample required?
A blood sample drawn from an infant’s heel, a spot of blood that is put onto filter paper, or a blood sample drawn from a vein in the arm.
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Trypsinogen (EC is the precursor form of the pancr ...
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