This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Condition	Treatment or Intervention	Phase
Alzheimer Disease Memory Disorders	Drug: Estrogen  Drug: Estrogen and Progesterone	Phase III

Further Study Details: 

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Ages Eligible for Study:  65 Years and above,  Genders Eligible for Study:  Female

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion Criteria:

• Significant neurological impairment
• Current estrogen use
• History of breast cancer

Alabama
      University of Alabama, Birmingham,  Alabama,  35294,  United States
California
      University of California, Irvine, Irvine,  California,  29697-4540,  United States
Connecticut
      New England Center for Headache, Stamford,  Connecticut,  06902-1249,  United States
District of Columbia
      Howard University, Washington,  District of Columbia,  20060,  United States
Florida
      Lee Memorial Health System, Fort Myers,  Florida,  33901,  United States
      Mayo Clinic Jacksonville, Jacksonville,  Florida,  32225,  United States
      North Broward Medical Center, Pompano Beach,  Florida,  United States
      St. Mary's Medical Center, West Palm Beach,  Florida,  33407,  United States
      Tallahassee Memorial Health Center, Tallahassee,  Florida,  32308,  United States
      Wein Center, Miami Beach,  Florida,  33140,  United States
      West Florida Regional Medical Center, Pensacola,  Florida,  32514,  United States
Maryland
      Johns Hopkins Bayview Medical Center, Baltimore,  Maryland,  21224,  United States
New Jersey
      Neurology Group of Bergen County, Ridgewood,  New Jersey,  07450,  United States
New York
      Burke Medical Research Institute, White Plains,  New York,  10605,  United States
      Columbia University, New York,  New York,  10032,  United States
      Cornell Medical Center, New York Presbyterian Medical Center, New York,  New York,  United States
      New York United Hospital Medical Center, Port Chester,  New York,  10573,  United States
North Carolina
      Duke University Medical Center, Durham,  North Carolina,  27710,  United States
Oklahoma
      Clinical Pharmaceutical Trials, Tulsa,  Oklahoma,  74104-5428,  United States
Rhode Island
      Butler Hospital, Rhode Island Hospital, Providence,  Rhode Island,  02906,  United States
South Carolina
      Medical University of South Carolina, North Charleston,  South Carolina,  29406,  United States
Virginia
      Eastern Virginia Medical School, Norfolk,  Virginia,  23507-1912,  United States

Study chairs or principal investigators

Mary Sano, PhD,  Principal Investigator,  Mount Sinai Medical Center   

Study ID Numbers:  IA0018; RO 1AG15922-01
Record last reviewed:  October 2004
Last Updated:  October 14, 2004
Record first received:  October 29, 1999
ClinicalTrials.gov Identifier:  NCT00000176
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08