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Article: Gamma glutamyl transpeptidase
| [[Image:|px|Gamma glutamyl transpeptidase chemical structure]] | |
| gamma-glutamyltransferase 1 | |
| Identifiers | |
| Symbol(s) | GGT1 GGT |
| Entrez | 2678 |
| OMIM | 231950 |
| RefSeq | NM_001032364 |
| UniProt | P19440 |
| PDB | [1] |
| Other data | |
| EC number | 2.3.2.2 |
| Locus | Chr. 22 q11.1-11.2 |
| [[Image:|px|Gamma glutamyl transpeptidase chemical structure]] | |
| gamma-glutamyltransferase 2 | |
| Identifiers | |
| Symbol(s) | GGT2 GGT |
| Entrez | 2679 |
| OMIM | 137181 |
| RefSeq | NM_002058 |
| UniProt | P36268 |
| PDB | [2] |
| Other data | |
| EC number | 2.3.2.2 |
| Locus | Chr. 22 q11.1-11.2 |
| [[Image:|px|Gamma glutamyl transpeptidase chemical structure]] | |
| gamma-glutamyltransferase 3 | |
| Identifiers | |
| Symbol(s) | GGT3 |
| Entrez | 2680 |
| OMIM | [3] |
| RefSeq | [4] |
| UniProt | [5] |
| PDB | [6] |
| Other data | |
| EC number | 2.3.2.2 |
| Locus | Chr. 22 [7] |
Gamma glutamyl transferase (GGT or GGTP, or Gamma-GT) (EC 2.3.2.2) is a liver enzyme. The enzyme is also present in other tissues, such as the epididymis. Its level in the blood may be tested for, as an elevated level may indicate an abnormality in the liver, though this can be caused by a number of conditions including:
- congestive heart failure
- cholestasis (congestion of the bile ducts)
- cirrhosis of the liver
- Restricted blood flow to the liver
- Necrosis of the liver
- Liver tumors
- hepatitis
- hepatotoxic drugs
Its levels are increased in chronic and acute alcohol abuse.
Resources
- GGT (Lab Tests Online)
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