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APEX: Adiposity Prevention by Exercise in Black Girls - Article


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Urologic Diseases Dictionary

Urology 




Clinical Trial: APEX: Adiposity Prevention by Exercise in Black Girls

This study is no longer recruiting patients.

Sponsored by: National Heart, Lung, and Blood Institute (NHLBI)
Information provided by: National Heart, Lung, and Blood Institute (NHLBI)

Purpose

To determine whether a one year afternoon exercise program will reduce adiposity in African American girls, ages 8 to 10.

Condition Treatment or Intervention
Cardiovascular Diseases
Heart Diseases
Obesity
 Behavior: Exercise

MedlinePlus related topics:  Heart Diseases;   Heart Diseases--Prevention;   Obesity;   Vascular Diseases

Study Type: Observational
Study Design: Natural History, Defined Population

Further Study Details: 

Study start: April 2000;  Study completion: March 2005

BACKGROUND: Obese children who engage in vigorous exercise programs show beneficial effects on total body percent fat (percent BF) and visceral adipose tissue (VAT); however, little is known about how to prevent accretion of total body or visceral adiposity in high risk youths, such as African-American (AA) females.The project has important health implications for two reasons, as follows. There is a dearth of information concerning the effects of exercise interventions in school and community settings. If the study shows that an afternoon exercise program reduces accretion of general and visceral adiposity and has a favorable impact on fitness and health in a population that is at high risk of obesity, then schools may be encouraged to implement similar interventions to prevent juvenile obesity and associated health problems.

The study was awarded in response to a Program Announcement on Physical Activity and Cardiopulmonary Health released in October 1994 jointly by the NHLBI, the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute of Nursing Research.

DESIGN NARRATIVE: The design involves randomization of 200 African American girls, eight to 10 years of age into intervention or control groups. After one year, the groups are compared to test the primary hypothesis that a one year afternoon exercise program will reduce accretion of general and visceral adiposity in these girls. Then the girls will switch group assignments for the next year. The pattern of data over the three time points will show what happens over a two year period in which the youths are, or are not, involved in the exercise program. The measurements will include: (1) percent body fat with dual-energy x-ray absorptiometry; (2) visceral adipose tissue (VAT) with magnetic resonance imaging; (3) cardiovascular fitness with a multi-stage treadmill test; (4) cardiovascular disease (CVD) risk factors (i.e., the ratio of total to high density lipoprotein cholesterol, insulin, systolic blood pressure, and fibrinogen); (5) free-living exercise and diet; (6) psychosocial variables (i.e., self-efficacy and self-concept); (7) sexual maturation; (8) anthropometric measures. The exercise program will be implemented in neighborhood schools for 90 minutes each weekday afternoon. Transportation will be provided if needed. Sessions will include motor skill instruction and aerobic exercises.

Eligibility

Ages Eligible for Study:  8 Years   -   10 Years,  Genders Eligible for Study:  Female

Criteria

No eligibility criteria

Location Information

Study chairs or principal investigators

Paule Barbeau,  Medical College of Georgia   

More Information

Publications

Gutin B, Yin Z, Humphries MC, Hoffman WH, Gower B, Barbeau P. Relations of fatness and fitness to fasting insulin in black and white adolescents. J Pediatr. 2004 Dec;145(6):737-43.

Study ID Numbers:  930
Record last reviewed:  December 2004
Last Updated:  January 10, 2005
Record first received:  October 12, 2000
ClinicalTrials.gov Identifier:  NCT00006405
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 8, 2005

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November 25, 2009



Page Updated: September 6, 2005
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