Post Traumatic Stress Disorder/ptsd |
|
|
Clinical Trial: Cognitive Behavioral Treatments for Post-traumatic Stress Disorder (PTSD) Sleep Disturbance
This study is currently recruiting patients.
|
Purpose
The purpose of this study is to compare the effectiveness of two cognitive behavioral group psychotherapy interventions in controlling the subjective sleep disturbance in veterans with Post-traumatic Stress Disorder.
| Condition | Treatment or Intervention |
|---|---|
| Post-Traumatic Stress Disorder | Behavior: Imagery Rehearsal Behavior: Sleep and Nightmare Management |
MedlinePlus related topics: Post-Traumatic Stress Disorder
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study
Official Title: 7857 Cognitive - Behavioral Treatments for PTSD Sleep Disturbance
Expected Total Enrollment: 150
Study start: April 2004; Expected completion: January 2007
Repetitive, stereotypical nightmares and insomnia commonly characterize post-traumatic stress disorder (PTSD). Identifying the pathophysiological mechanisms of disrupted sleep in PTSD has therefore assumed considerable clinical importance. We previously reported an increase in rapid eye movement activity (REM activity) during REM sleep (REMS) in Vietnam War combat veterans with PTSD, and this finding can be seen as consistent with the view that most, although not all, dreaming occurs during REMS and the repeated observation that REM activity correlates with the intensity of dream mentation. There is a growing body of evidence that post-traumatic nightmares can respond to psychological treatment interventions. Namely, a cognitive-behavioral technique entitled imagery rehearsal (IR) has been reported to be effective in the treatment of such nightmares in victims of crime and in women who have been sexually assaulted. In a small pilot study, it has also been reported to be effective in the treatment of Vietnam veterans with combat-related PTSD. The two objectives of this proposal are: 1. To compare, in a study with random assignment and a parallel group design, the effectiveness in controlling the subjective sleep disturbance in veterans with PTSD of IR and Sleep and Nightmare Management (SN), a psychological treatment that targets life stressors and problems with sleep hygiene that may exacerbate insomnia and nightmares. 2. In a subset of these subjects, to compare the effectiveness in reducing REM activity of IR and SN.
Eligibility
Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
- Male
- Vietnam Combat Veteran
- Diagnosis of combat-related PTSD
- Stable psychotropic regimen for a minimum of three months
- Experiences recurrent nightmares
Exclusion Criteria:
- Bipolar disorder, delirium, dementia, amnestic and other cognitive disorders
- Schizophrenia and other psychotic disorders
- Substance abuse or dependence within the last six months
- Untreated medical disorders known to impact sleep
Location and Contact Information
Pennsylvania
VA Medical Center, Philadelphia, Pennsylvania, 19104, United States; Recruiting
Joan Cook, Ph.D., Principal Investigator
Richard Ross, M.D., Ph.D., Principal Investigator
More Information
Record last reviewed: April 2005
Last Updated: April 15, 2005
Record first received: April 15, 2005
ClinicalTrials.gov Identifier: NCT00108628
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-05-03
Source: ClinicalTrials.gov
Cache Date: May 4, 2005
Resources
- Accommodations For People with PTSD (Job Accommodation Network)
- Anxiety Disorders (National Mental Health Information Center, SAMHSA, HHS)

Not Signed In -

