Not Signed In -
Post Traumatic Stress Disorder/ptsd |
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Clinical Trial: Guanfacine for the Treatment of Post Traumatic Stress Disorder (PTSD)
This study has been completed.
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Purpose
This is a double-blind, placebo-controlled, randomized study lasting 8 weeks. Purpose of the study is two-fold: first, to use a pharmacological agent to treat symptoms of PTSD, and second, to explore neurobiological mechanisms of action of guanfacine.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Post-Traumatic Stress Disorder | Drug: guanfacine | Phase I |
MedlinePlus related topics: Post-Traumatic Stress Disorder
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title: Guanfacine for the Treatment of PTSD
Study start: November 1999; Study completion: October 2002
Subject population is comprised of 100 persons with PTSD. 50 patients will receive guanfacine and 50 patients will receive a placebo. Guanfacine is prescribed at 1 mg/day and may be increased to 2 mg/day. Samples of plasma MHPG will be collected weekly. Clinical ratings of PTSD anxiety and depression, as well as vital signs, will be assessed weekly. Repeated measures analysis of variance will assess significance of main effect of drug, time, and drug by time.
Eligibility
Ages Eligible for Study: 18 Years - 65 Years, Genders Eligible for Study: Both
Criteria
- Males and females, age 18-65
- Diagnosis of PTSD from combat or civilian trauma
- No major medical problems such as diabetes, cardiovascular disease
- Taking no psychiatric medication, or taking only one SSRI antidepressant
Location Information
Connecticut
VA Connecticut Healthcare System, West Haven, Connecticut, 06516, United States
More Information
Record last reviewed: December 2004
Last Updated: December 30, 2004
Record first received: July 3, 2001
ClinicalTrials.gov Identifier: NCT00018603
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Accommodations For People with PTSD (Job Accommodation Network)
- Anxiety Disorders (National Mental Health Information Center, SAMHSA, HHS)
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