Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. The declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. Elderly hip fracture patients often have significant decreases in muscle mass. The purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.

Condition	Treatment or Intervention
Hip Fractures Muscular Atrophy	Behavior: Exercise

Ages Eligible for Study:  65 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Enrollment in HSC protocol #97-0695 "Rehabilitation Intensification Post Hip Fracture"
• Community-dwelling
• Hip fracture within 16 weeks of the screening assessment for protocol 97-0695
• Persistent mobility and/or ADL impairments, but independent in ambulation
• Modified Physical Performance Test (PPT) score between 12 and 28

Missouri
      Washington University, St. Louis,  Missouri,  63110,  United States

Study ID Numbers:  NCRR-M01RR00036-0764; M01RR00036
Record last reviewed:  December 2003
Last Updated:  October 13, 2004
Record first received:  September 7, 2000
ClinicalTrials.gov Identifier:  NCT00006194
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08