Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease. Despite its benign nature, this condition causes anxiety, impairs quality of life and consumes a substantial amount of healthcare resources. While acid reflux and motility disorder in the esophagus are often attributed as the cause of NCCP, visceral hyperalgesia of esophagus is now recognized to play a central role in the pathogenesis of this condition. This research project aims to evaluate the role of visceral hyperalgesia in Chinese patients with NCCP. NCCP patients will be evaluated for the prevalence of gastroesophageal reflux disease and esophageal motility disorder by endoscopy, manometry and pH study. The visceral sensory and pain thresholds of these patients will be compared with asymptomatic controls.

Condition
Non-cardiac Chest Pain

Further Study Details: 

Expected Total Enrollment:  100

Ages Eligible for Study:  18 Years   -   70 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
• Age between 18-70

Exclusion Criteria:

• Gastroesophageal reflux disease
• Psychiatric illness
• Cerebrovascular accident
• Active peptic ulceration
• Heart failure or cardiac bradyarrhythmia
• Epilepsy
• Pregnancy or lactating female
• Previous hypersensitivity to muscle relaxant

Please refer to this study by ClinicalTrials.gov identifier  NCT00164814

Justin CY WU, MD      85226323024    carriancheung@cuhk.edu.hk
Carrian MY CHEUNG, BN      85226323855    carriancheung@cuhk.edu.hk

China
      Endoscopy Centre, Prince of Wales Hospital, Hong Kong,  China

Study chairs or principal investigators

Justin CY WU, MD,  Principal Investigator,  Chinese University of Hong Kong   

Study ID Numbers:  NPA study
Last Updated:  September 13, 2005
Record first received:  September 9, 2005
ClinicalTrials.gov Identifier:  NCT00164814
Health Authority: Hong Kong: Department of Health
ClinicalTrials.gov processed this record on 2005-09-20