Clinical Trial: Use Of GW274150 In The Prophylactic Treatment Of Migraine

This study is not yet open for patient recruitment.
Verified by GlaxoSmithKline October 2005

Sponsored by: GlaxoSmithKline
Information provided by: GlaxoSmithKline
ClinicalTrials.gov Identifier: NCT00242866

Purpose

Nitric oxide (NO) is likely to be involved in the development of migraine headache. Nitric oxide synthase (NOS) is an important chemical involved in the production of NO. Reduction of NOS, and therefore NO, may be an efective technique for the prevention of migraine headache. GW274150 is a highly selective inhibitor of NOS and offers the potential of anti-inflammatory activity in migraine through a novel mechanism of action. The intent of this study is to investigate the safety and efficacy of GW274150 for the prophylactic treatment of migraine headache.
Condition Intervention Phase
Migraine
 Drug: GW274150
Phase II

MedlinePlus related topics:  Migraine

Study Type: Interventional
Study Design: Prevention, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study

Official Title: A Multicentre, Two-Part, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Tolerability and Pharmacokinetics of the iNOS Inhibitor GW274150 Administered Up to 120mg Daily for 12 Weeks in the Prophylactic Treatment of Migraine.

Further study details as provided by GlaxoSmithKline:
Primary Outcomes: Occurrence of a migraine headache day on each day during the 4-week baseline period and the 12-week treatment period.
Secondary Outcomes: Change in number of migraine headache days, migraine attacks, mean peak migraine pain severity and mean migraine headache duration.
Expected Total Enrollment:  375

Study start: October 2005

Eligibility

Ages Eligible for Study:  18 Years   -   55 Years,  Genders Eligible for Study:  Both
Criteria

Inclusion Criteria:

  • Suffering from migraine with or without aura.
  • Migraine for at least one year, and the age of onset was prior to 50 years.
  • Consistent migraine headache over time and has had at least 3 migraine headache attacks but less than 15 days with headache (migraine or non-migraine) per month in each of the three months prior to the Screening Visit and maintains this requirement during the baseline period.
  • Able to distinguish migraine headache attacks as discreet attacks from other headaches (i.e. tension-type headaches).
  • No clinically significant abnormality identified on the medical or laboratory evaluation. A subject with a clinical abnormality or laboratory parameters outside the reference range may be included only if the doctor considers that the finding will not introduce additional risk factors and will not interfere with the study procedures.
  • Written informed consent prior to entry into the study.
  • Females who are: a) non-childbearing potential or, b) of child-bearing potential, has a negative pregnancy test at screen, and is taken adequate contraceptive measures.

Exclusion Criteria:

  • As a result of the medical interview, physical examination or screening investigations, that the doctor considers the subject unfit for the study.
  • Headache for 15 days per month or greater in any of the three months (90 days) preceding the Screening Visit.
  • History of alcohol, substance or drug abuse within the last year.
  • Taken a migraine prophylactic medication within 1 month of the Screening Visit.
  • Uses an opiate as first line acute treatment for migraine attacks.
  • History of ergotamine, triptan, opioid, or combination medication intake on greater than/equal 10 days per month on a regular basis for greater than/equal 3 months.
  • History of simple analgesic intake on greater than/equal 15 days per month for greater than/equal 3 months.
  • Failed two or more adequate treatments of migraine prophylaxis, where failure is defined as a lack of efficacy with a treatment duration of at least 8 weeks or withdrawal of treatment due to treatment intolerance.
  • Uncontrolled hypertension at the Screening Visit, defined as systolic blood pressure >140mmHg or diastolic blood pressure >90mmHg.
  • Taking cyclosporine and/or aminoglycosides.
  • Evidence of renal impairment - calculated creatinine clearance <60ml/min or clinically relevant finding on urinalysis.
  • History of drug or other allergy which, in the opinion of the doctor, makes the subject unsuitable for participation in the study.
  • Concurrently participating in another clinical study or investigational drug trial or has participated within the previous 3 months or is planning to participate in another drug or device study at any time during this study (screening through follow-up) or has had previous exposure to GW274150 in Part 1 of the study.
  • Felt to be at risk of non-compliance (for taking study medication or for completing the electronic diary (e-diary)), in the doctor''''s opinion.
  • Pregnant or nursing women.
  • History of, or risk factors for, HIV, Hepatitis B and Hepatitis C.
  • Past or present disease, which as judged by the doctor, may affect the outcome of this study. These diseases include, but are not limited to history of liver or renal disease in the 6 months prior to screening.
  • Clinically significant abnormalities in safety laboratory analysis at the Screening Visit, particularly any abnormal liver or pancreatic function test at the Screening Visit.
  • Not covered by social security.

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00242866


Belgium
      GSK Clinical Trials Call Center, Leuven,  Belgium
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Antwerpen,  Belgium
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Liege,  Belgium
GSK Clinical Trials Call Center  1-877-379-3718 

Denmark
      GSK Clinical Trials Call Center, Glostrup,  Denmark
GSK Clinical Trials Call Center  1-877-379-3718 

France
      GSK Clinical Trials Call Center, Montbrison,  France
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Lille Cedex,  France
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Luynes,  France
GSK Clinical Trials Call Center  1-877-379-3718 

Germany
      GSK Clinical Trials Call Center, Koenigstein,  Germany
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Kiel,  Germany
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Huettenberg,  Germany
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Hamburg,  Germany
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Essen,  Germany
GSK Clinical Trials Call Center  1-877-379-3718 

Netherlands
      GSK Clinical Trials Call Center, Blaricum,  Netherlands
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Nijmegen,  Netherlands
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Venray,  Netherlands
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Hengelo,  Netherlands
GSK Clinical Trials Call Center  1-877-379-3718 

Norway
      GSK Clinical Trials Call Center, Hamar,  Norway
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Oslo,  Norway
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Bergen,  Norway
GSK Clinical Trials Call Center  1-877-379-3718 

      GSK Clinical Trials Call Center, Sandvika,  Norway
GSK Clinical Trials Call Center  1-877-379-3718 

Study chairs or principal investigators

GSK Clinical Trials, MD,  Study Director,  GlaxoSmithKline   

More Information

Study ID Numbers:  NOS103325
Last Updated:  December 8, 2005
Record first received:  October 19, 2005
ClinicalTrials.gov Identifier:  NCT00242866
Health Authority: Germany: Federal Institute for Drugs and Medicinal Devices
ClinicalTrials.gov processed this record on 2006-01-10

Resources




Common Treatments

[ Disclaimer: The information on GoldBamboo for any particular treatment, medicine, drug, or herbal product might be missing or incomplete, and should never be used as a single source of knowledge. GoldBamboo generally has links to authoritative sites displayed toward the bottom of each topic page under the heading "Resources". ]

Follow Us