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Male Genital Disorders |
Penile Disorders; Testicular Disorders |
Clinical Trial: Nefazodone in the Treatment of Cocaine Dependence and Depression - 4
This study is no longer recruiting patients.
Purpose
The purpose of this study is the use of Nefazodone in the treatment of cocaine dependence and depression comorbidity.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Cocaine-Related Disorders Substance-Related Disorders | Drug: Nefazodone | Phase II |
MedlinePlus related topics: Cocaine Abuse; Drug Abuse; Prescription Drug Abuse
Study Type: Interventional
Study Design: Treatment, Placebo Control
Official Title: Efficacy of Nefazodone in Cocaine Dependent Subjects
Study start: February 1997; Study completion: January 1999
The objective of this study is to determine the safety and efficacy of nefazodone (Serzone ) in depressed cocaine dependent subjects. This is a hypothesis-testing study which will explore whether cocaine usage will be reduced in the nefazodone treatment group compared to a placebo control group.
Eligibility
Ages Eligible for Study: 21 Years - 55 Years, Genders Eligible for Study: Both
Criteria
Inclusion Criteria:
DSM-IV diagnosis of cocaine dependence, Depression score of 12 or above and history of depression. Males and non-pregnant, non-nursing females 21-55 years of age.
Exclusion Criteria:
Axis I diagnosis other than substance use disorder, major depression, anxiety of dysthymic disorder. Physiological dependence on alcohol. Significant medical or neurological history. Abnormal UA, CBC or Chem 23 (LFT's may be up to 3 times normal). Enrollment in an opiate-substitution treatment program within 45 days of enrollment in the present study.
Location Information
New York
New York MDRU, New York, New York, 10010, United States
John Rotrosen, M.D., Principal Investigator, New York MDRU
More Information
Record last reviewed: February 1997
Last Updated: February 16, 2005
Record first received: April 18, 2001
ClinicalTrials.gov Identifier: NCT00015210
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Ambiguous Genitalia (Mayo Foundation for Medical Education and Research)
- American Foundation for Urologic Disease
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