Clinical Trial: Prevention of Depression in At-Risk Adolescents

This study is currently recruiting patients.

Sponsored by: National Institute of Mental Health (NIMH)
Information provided by: National Institute of Mental Health (NIMH)

Purpose

The purpose of this study is to determine the impact of a group cognitive behavioral program (CBP) on the depressive symptoms and disorders of adolescents at risk for developing depression.

Condition Treatment or Intervention
Depression
 Behavior: Cognitive Behavioral Program

MedlinePlus related topics:  Depression

Study Type: Interventional
Study Design: Prevention, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Further Study Details: 

Expected Total Enrollment:  320

Study start: August 2003;  Expected completion: January 2008

Depression is a prevalent, chronic, and impairing condition that is often undetected and becomes more difficult to treat as chronicity increases. There is an increasing need to develop large-scale depression prevention studies in adolescents. This study will evaluate a cognitive-behavioral prevention program to determine its effectiveness in preventing depression in at-risk adolescents. The study also will ascertain the costs and benefits of incorporating this intervention into "real world" settings.

Participants in this study will be randomly assigned to receive either CBP or usual care for 32 months. Depressive symptoms, levels of functioning, and medical and mental health care utilization will be assessed at baseline and again at 2, 8, 20, and 32 months after intake.

Eligibility

Ages Eligible for Study:  13 Years   -   17 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

  • Have a parent with depression
  • Past depressive episode or current subsyndromal depressive symptoms

Location and Contact Information

Judy Garber, PhD      615-343-8714    Judy.Garber@Vanderbilt.edu

Massachusetts
      Harvard University Medical School, Boston,  Massachusetts,  02115-5794,  United States; Recruiting
William Beardslee, MD  617-232-8390  Ext. 2221    william.beardslee@tch.harvard.edu 
William Beardslee, MD,  Principal Investigator

Oregon
      Kaiser Permanente Center for Health Research, Portland,  Oregon,  97227,  United States; Recruiting
Stephanie Hertert  503-335-2411 
Greg Clarke, PhD  503-335-6673    greg.clarke@kp.org 
Greg Clarke, PhD,  Principal Investigator

Pennsylvania
      University of Pittsburgh Medical Center, Pittsburgh,  Pennsylvania,  15213-2593,  United States; Recruiting
David Brent, MD  412-246-5616    brentda@msx.upmc.edu 
David Brent, MD,  Principal Investigator

Tennessee
      Vanderbilt University, Nashville,  Tennessee,  37203-5721,  United States; Recruiting
Judy Garber, PhD  615-343-8714    Judy.Garber@Vanderbilt.edu 
Judy Garber, PhD,  Principal Investigator

More Information

Publications

Clarke GN, Hornbrook M, Lynch F, Polen M, Gale J, Beardslee W, O'Connor E, Seeley J. A randomized trial of a group cognitive intervention for preventing depression in adolescent offspring of depressed parents. Arch Gen Psychiatry. 2001 Dec;58(12):1127-34.

Study ID Numbers:  MH64735-01A1-2
Record last reviewed:  March 2005
Last Updated:  March 24, 2005
Record first received:  December 2, 2003
ClinicalTrials.gov Identifier:  NCT00073671
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005