Not Signed In -
Alpha-1 Antitrypsin Deficiency |
AAT; alpha-1 proteinase inhibitor; alpha-1 related emphysema; genetic emphysema; hereditary pulmonary emphysema; inherited emphysema |
Alpha-1 is an inherited disorder that may result in you developing a serious lung/ liver disease and passing the defective AAT gene onto your children. An estimated 100,000 people in the U.S. and a similar number in Europe are estimated to have the severe deficiency. In normal individuals large amounts of alpha-1 antitrypsin (AAT) is made in the liver and released into the blood. In AAT deficient individuals, the AAT made in the liver cannot be fully released into the blood.
... Alpha-1 antitrypsin deficiency is an inherited disorder that can cause lung disease in adults and liver disease in adults and children.
The first signs of lung disease caused by alpha-1 antitrypsin deficiency usually appear between ages 20 and 40. The earliest symptoms are shortness of breath following mild activity, reduced ability to exercise, and wheezing. Other symptoms can include unintentional weight loss, recurring respiratory infections, fatigue, a barrel-shaped chest, rapid heartbeat upon standing, and vision abnormalities. Smoking or exposure to tobacco smoke accelerates the appearance of symptoms and damage to the lungs.
About 10 percent of infants and 15 percent of adults also have liver damage caused by alpha-1 antitrypsin deficiency. Symptoms of liver disease can include a swollen abdomen, coughing up blood, swollen feet or legs, and yellowing of the skin and whites of the eyes (jaundice).
In rare cases, alpha-1 antitrypsin deficiency also causes a skin condition known as panniculitis, which is characterized by hardened skin with painful lumps or patches. Panniculitis varies in severity and can occur at any age. ...
... Alpha-1 antitrypsin (AAT) deficiency is condition passed down through families in which the liver does not make enough of a protein that protects the lungs and liver from damage. The condition can lead to emphysema and liver disease. ...
Alpha 1-antitrypsin deficiency (A1AD or Alpha-1) is a genetic disorder caus ...
From the WEST scientific·clinical |
From the EAST traditional·alternative |
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Related Medications |
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Alpha-1 Antitrypsin Deficiency Other1-2 of 3 more...
Understanding Alpha-1
Antitrypsin Deficiency
... What is alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin is a protein that is made in the liver. The liver releases this protein into the bloodstream. Alpha-1 antitrypsin protects the lungs so they...
Source: Cleveland Clinic
New Effort Seeks Increased Awareness of Lung Disorder ... A new initiative is underway to optimize the management of patients with a fairly common and potentially lethal lung disease known as alpha-1 antitrypsin disorder, or alpha-1. Part of the initiative i...
Source: Cleveland Clinic
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Alpha-1 Antitrypsin Deficiency Articles
- Alpha-1 antitrypsin deficiency
... Alpha-1 antitrypsin deficiency is an inherited disorder that can cause lung disease in adults and liver disease in adults and children. The first signs of lung disease caused by alpha-1 antitrypsin de...
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