Not Signed In -
Alpha-1 Antitrypsin Deficiency |
AAT; alpha-1 proteinase inhibitor; alpha-1 related emphysema; genetic emphysema; hereditary pulmonary emphysema; inherited emphysema |
Clinical Trial: Genetics of Alpha Thalassemia in Israeli Ethnic Groups
This study is currently recruiting patients.
Verified by Hadassah Medical Organization September 2005
|
Purpose
Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.
We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.
| Condition |
|---|
| alpha Thalassemia |
MedlinePlus related topics: Anemia
Study Type: Observational
Study Design: Screening, Longitudinal, Convenience Sample, Retrospective Study
Official Title: Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups
Study start: October 2004
Last follow-up: September 2005
Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.
We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.
Eligibility
Inclusion Criteria:
- diagnosis of deletional alpha thalassemia
Exclusion Criteria:
- under age 18
Location and Contact Information
Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Israel
Hadassah Medical Organization, Jerusalem, Israel; Recruiting
Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Deborah Rund, MD, Principal Investigator
Deborah Rund, MD, Principal Investigator, Hadassah Medical Organization
More Information
Publications
Rund D, Filon D, Jackson N, Asher N, Oron-Karni V, Sacha T, Czekalska S, Oppenheim A. An unexpectedly high frequency of heterozygosity for alpha-thalassemia in Ashkenazi Jews. Blood Cells Mol Dis. 2004 Jul-Aug;33(1):1-3.
Last Updated: September 11, 2005
Record first received: September 9, 2005
ClinicalTrials.gov Identifier: NCT00159029
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
ClinicalTrials.gov processed this record on 2005-09-13
email this page
print this page
bookmark this page
feedback on this page
