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Alpha-1 Antitrypsin Deficiency |
AAT; alpha-1 proteinase inhibitor; alpha-1 related emphysema; genetic emphysema; hereditary pulmonary emphysema; inherited emphysema |
Alpha 1-antitrypsin deficiency (A1AD or Alpha-1) is a genetic disorder caused by reduced levels of alpha 1-antitrypsin in the blood. It can lead to emphysema and, in some cases, to liver disease. Signs and symptoms Symptoms of alpha-1 antitrypsin deficiency include shortness of breath, recurring respiratory infections, or obstructive asthma that does not respond to treatment. Individuals with alpha-1 may develop emphysema during their thirties or forties, without a history of significan ...
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Alpha-1 Antitrypsin Deficiency Clinical Trials
- 4-PBA: Will it increase the level of Alpha 1-Antitrypsin(AAT) in persons with AAT deficiency?
ClinicalTrials.gov Identifier: NCT00067756 - Active, not recruiting
alpha 1-Antitrypsin Deficiency
- Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00157092 - Completed
alpha 1-Antitrypsin Deficiency
- Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00377416 - Active, not recruiting
Alpha 1-Antitrypsin Deficiency
- Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00430768 - Recruiting
Alpha 1-Antitrypsin Deficiency
- The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00532805 - Recruiting
Alpha-1 Antitrypsin Deficiency
- Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects with Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00161707 - Completed
alpha 1-Antitrypsin Deficiency
- Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00460096 - Completed
Alpha 1-Antitrypsin Deficiency
- The Safety and Tolerability of Alpha-1 MP in Subjects With Alpha-1-Antitrypsin (AAT) Deficiency.
ClinicalTrials.gov Identifier: NCT00301366 - Completed
Alpha 1-Antitrypsin Deficiency
- Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency
ClinicalTrials.gov Identifier: NCT00005098 - Terminated
alpha 1-Antitrypsin Deficiency
- The Comparison of the Pharmacokinetic, Safety and Tolerability of Alpha-1 MP and Prolastin in Adult alpha1-Antitrypsin Deficient Patients.
ClinicalTrials.gov Identifier: NCT00295061 - Completed
Alpha 1-Antitrypsin Deficiency
- Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals
ClinicalTrials.gov Identifier: NCT00001462 - Completed
Emphysema; Lung Diseases, Obstructive; alpha 1-Antitrypsin Deficiency
- Alpha-1 Coded Testing Study (ACT Trial)
ClinicalTrials.gov Identifier: NCT00500123 - Recruiting
Alpha 1-Antitrypsin Deficiency
- Alpha-1 Foundation Research Registry
ClinicalTrials.gov Identifier: NCT00499941 - Recruiting
Alpha 1-Antitrypsin Deficiency
- Efficacy and Safety Study of Augmentation Therapy With Aralast (Human Alpha 1 - Proteinase Inhibitor)
ClinicalTrials.gov Identifier: NCT00396006 - Recruiting
Alpha 1-Antitrypsin Deficiency
- Pharmacokinetic Study of Aralast (Human Alpha1- PI)
ClinicalTrials.gov Identifier: NCT00242385 - Completed
Alpha 1-Antitrypsin Deficiency
- Aralast alpha1-Proteinase Inhibitor Surveillance Study
ClinicalTrials.gov Identifier: NCT00313144 - Active, not recruiting
Alpha 1-Antitrypsin Deficiency
- Alpha1-antitrypsin Deficiency Registry
ClinicalTrials.gov Identifier: NCT00005292 - Completed
Lung Diseases; Emphysema; Alpha-1 antitrypsin deficiency; Chronic Obstructive Pulmonary Disease
- Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients
ClinicalTrials.gov Identifier: NCT00263887 - Completed
Alpha 1-Antitrypsin Deficiency
- Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases
ClinicalTrials.gov Identifier: NCT00571272 - Recruiting
Liver Diseases; Alagille Syndrome; Alpha 1-Antitrypsin Deficiency
- Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients
ClinicalTrials.gov Identifier: NCT00499837 - Recruiting
Cystic Fibrosis
- Prepubertal Children with Growth Failure Associated with Primary IGF-1 Deficiency
ClinicalTrials.gov Identifier: NCT00125164 - Active, not recruiting
Insulin-Like Growth Factor-1 Deficiency; Primary IGF-1 Deficiency
- Recombinant Human Insulin-Like Growth Factor (rhIGF-1)Treatment of Short Stature Associated with IGF-1 Deficiency
ClinicalTrials.gov Identifier: NCT00125190 - Active, not recruiting
Insulin-Like Growth Factor-1 Deficiency; Primary IGF-1 Deficiency; IGF-1
- Genetics of Alpha Thalassemia in Israeli Ethnic Groups
ClinicalTrials.gov Identifier: NCT00159029 - Recruiting
alpha Thalassemia
- Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon
ClinicalTrials.gov Identifier: NCT00226408 - Recruiting
Adjuvant; Stage III Malignant Melanoma; Interferon Alpha; Therapy
- Gene Therapy for Patients with Leukocyte Adherence Deficiency (Follow-Up of Phase 1 Trial)
ClinicalTrials.gov Identifier: NCT00023010 - Active, not recruiting
Leukocyte Adhesion Deficiency Syndrome
- Phase I Study of Retrovirus-Mediated Transfer of cDNA for Human CD18 into Peripheral Blood Repopulating Cells of Patients With Leukocyte Adherence Deficiency
ClinicalTrials.gov Identifier: NCT00004470 - Active, not recruiting
Leukocyte Adhesion Deficiency Syndrome
- ABR-217620 With Interferon-Alpha (IFN-Alpha) Compared to IFN-Alpha Alone in Patients With Advanced Renal Cell Carcinoma
ClinicalTrials.gov Identifier: NCT00420888 - Recruiting
Renal Cell Carcinoma
- Open Label Phase 3 Study of NABI-IGIV 10% [(HUMAN)] In Subjects With Primary Immune Deficiency Disorders (PIDD)
ClinicalTrials.gov Identifier: NCT00538915 - Recruiting
Primary Immune Deficiency Disorders; Antibody Deficiency Syndromes
- Bezafibrate Trial in CPT2 Deficiency
ClinicalTrials.gov Identifier: NCT00336167 - Recruiting
Carnitine Palmitoyl Transferase 2 Deficiency
- PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency
ClinicalTrials.gov Identifier: NCT00246870 - Recruiting
Succinic Semialdehyde Dehydrogenase Deficiency; SSADH Deficiency
- Efficacy and Safety of a High Dosage Compared to the Label Dosage of Somatropin in Early Pubertal Stage Children With Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00191165 - Active, not recruiting
Growth Hormone Deficiency
- A Multi-Dose Study to Assess Tolerability, Safety and Pharmacology of hGH-ViaDerm™ System in Adults With GH-Deficiency
ClinicalTrials.gov Identifier: NCT00455260 - Recruiting
Growth Hormone Deficiency
- A Clinical Study of the PK, Efficacy and Safety of Omr-IgG-am IGIV in Subjects With Primary Immune Deficiency Diseases
ClinicalTrials.gov Identifier: NCT00468273 - Recruiting
Immunologic Deficiency Syndromes
- Ferinject® Assessment in Patients With IRon Deficiency and Chronic Heart Failure (FAIR-HF)
ClinicalTrials.gov Identifier: NCT00520780 - Recruiting
Chronic Heart Failure; Iron Deficiency; Iron Deficiency Anemia; Anaemia
- Helicobacter Pylori and Iron Deficiency: Prevalence of Association and Effect of Therapy
ClinicalTrials.gov Identifier: NCT00475527 - Active, not recruiting
Anemia, Iron-Deficiency; Helicobacter Pylori
- Zemaira in Subjects With Emphysema Due to API Deficiency
ClinicalTrials.gov Identifier: NCT00261833 - Recruiting
Alpha1-Proteinase Inhibitor Deficiency
- Comparative Results of Maxillary Deficiency Treatment by Tongue Plate and Facemask in Growing Patients
ClinicalTrials.gov Identifier: NCT00519415 - Recruiting
Orthodontic Angle Class Three; Maxillary Deficiency
- The Natural History of Alpha-Mannosidosis
ClinicalTrials.gov Identifier: NCT00498420 - Recruiting
Alpha Mannosidosis
- A Study of the Efficacy and Safety of Genz-112638 in Type 1 Gaucher Patients
ClinicalTrials.gov Identifier: NCT00358150 - Active, not recruiting
Gaucher Disease, Type 1; Cerebroside Lipidosis Syndrome; Glucocerebrosidase Deficiency Disease; Glucosylceramide Beta-Glucosidase Deficiency Disease; Gaucher Disease, Non-Neuronopathic Form
- H. Pylori Eradication Trial to Reduce Iron Deficiency in Children
ClinicalTrials.gov Identifier: NCT00364104 - Recruiting
Iron Deficiency
- Consequence of Lifetime Isolated Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00149708 - Recruiting
Growth Hormone Deficiency
- Provision of Antioxidant Therapy in Hemodialysis (PATH) Study
ClinicalTrials.gov Identifier: NCT00237718 - Recruiting
End Stage Renal Disease
- Safety and Efficacy of Recombinant Human Acid Alpha-Glucosidase in the Treatment of Classical Infantile Pompe Disease
ClinicalTrials.gov Identifier: NCT00025896 - Completed
Pompe Disease; Glycogen Storage Disease Type II; Acid Maltase Deficiency Disease; Glycogenosis 2
- Ingested Interferon Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Type 1 Diabetes Mellitus
ClinicalTrials.gov Identifier: NCT00005665 - Active, not recruiting
Diabetes Mellitus, Type 1
- Interferon-Alpha for Diabetes Mellitus Type 1
ClinicalTrials.gov Identifier: NCT00024518 - Active, not recruiting
Insulin-Dependent Diabetes Mellitus
- Recombinant Human Antithrombin (rhAT) in Patients with Hereditary Antithrombin Deficiency Undergoing Surgery or Delivery
ClinicalTrials.gov Identifier: NCT00110513 - Recruiting
Antithrombin III Deficiency
- Vitamin D Deficiency, Insulin Resistance and FGF-23
ClinicalTrials.gov Identifier: NCT00491322 - Recruiting
Vitamin D Deficiency
- Estrogen Deficiency and Cardiovascular Disease in Premenopausal Women
ClinicalTrials.gov Identifier: NCT00572858 - Recruiting
Estrogen Deficiency
- Safety and Efficacy of Cerezyme® Infusions Every 4 Weeks Versus Every 2 Weeks in Type 1 Gaucher Disease
ClinicalTrials.gov Identifier: NCT00364858 - Active, not recruiting
Gaucher Disease, Type 1; Cerebroside Lipidosis Syndrome; Glucocerebrosidase Deficiency Disease; Glucosylceramide Beta-Glucosidase Deficiency Disease; Gaucher Disease, Non-Neuronopathic Form
- A Single Dose Study to Evaluate the PK-PD Response and Safety of PHA-794428 in Children With Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00314938 - Recruiting
Growth Hormone Deficiency
- A Study To Evaluate The Dose Response And Safety Of PHA-794428 In Adults With Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00308464 - Recruiting
Growth Hormone Deficiency
- Characterization of Hyperparathyroidism and Vitamin D Deficiency in Obesity
ClinicalTrials.gov Identifier: NCT00288873 - Active, not recruiting
Vitamin D Deficiency; Secondary Hyperparathyroidism; Obesity
- Therapy of Early Chronic Phase Chronic Myelogenous Leukemia with Gleevec, Alpha Interferon, and Ara-C
ClinicalTrials.gov Identifier: NCT00048672 - Active, not recruiting
Leukemia, Myeloid, Chronic-Phase
- Molecular and Clinical Studies of Primary Immunodeficiency diseases
ClinicalTrials.gov Identifier: NCT00006319 - Recruiting
Immunologic Deficiency Syndrome
- rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency
ClinicalTrials.gov Identifier: NCT00572156 - Not yet recruiting
Insulin-Like Growth Factor-1 Deficiency
- Pharmacokinetics of Leptin Administration During Fasting
ClinicalTrials.gov Identifier: NCT00140205 - Active, not recruiting
energy deficiency due to short-term fasting
- Treatment of Adults With Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00294619 - Recruiting
Pituitary Disorders; Adult Growth Hormone Deficiency
- Phase I Study of Adenoviral Vector Mediated Gene Transfer for Ornithine Transcarbamylase in Adults with Partial Ornithine Transcarbamylase Deficiency
ClinicalTrials.gov Identifier: NCT00004498 - Active, not recruiting
Ornithine Transcarbamylase Deficiency Disease
- Safety and Efficacy of PRO 542 in the Treatment of HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00055185 - Active, not recruiting
HIV Infections; Acquired Immune Deficiency Syndrome
- Growth Hormone and Chromosome 18q- Abnormal Growth
ClinicalTrials.gov Identifier: NCT00134420 - Active, not recruiting
Chromosome 18; Growth Hormone Deficiency
- International Collaborative Gaucher Group (ICGG) Gaucher Registry
ClinicalTrials.gov Identifier: NCT00358943 - Recruiting
Gaucher Disease; Cerebroside Lipidosis Syndrome; Glucocerebrosidase Deficiency Disease; Glucosylceramide Beta-Glucosidase Deficiency Disease
- Dietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase Deficiency
ClinicalTrials.gov Identifier: NCT00260299 - Recruiting
Mevalonic Aciduria; Mevalonate Kinase Deficiency; Immune System Diseases; Periodic Fever Syndromes, Hereditary; Lipid Metabolism, Inborn Errors
- Genetic Basis of Primary Immunodeficiencies
ClinicalTrials.gov Identifier: NCT00001788 - Recruiting
Immunologic Deficiency Syndrome
- Examining Genetic Differences Among People With 21-Hydroxylase Deficiency
ClinicalTrials.gov Identifier: NCT00542841 - Recruiting
21-Hydroxylase Deficiency
- Efficacy of Prazosin Versus Placebo Associated with Peg-Interferon Alpha 2b and Ribavirin in Chronic Hepatitis C with Genotype 1 or 4 and Severe Fibrosis
ClinicalTrials.gov Identifier: NCT00148837 - Active, not recruiting
Hepatitis C, Chronic; Fibrosis
- Painful HIV Neuropathy and Alpha-Lipoic Acid
ClinicalTrials.gov Identifier: NCT00079807 - Active, not recruiting
HIV; Peripheral Neuropathy
- The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients
ClinicalTrials.gov Identifier: NCT00306410 - Recruiting
Vitamin D Deficiency; HIV Infections
- Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00182091 - Recruiting
Acromegaly; Growth Hormone Deficiency; Pituitary Disease
- Therapy of Early Chronic Phase Chronic Myelogenous Leukemia (CML) with Higher-Dose Gleevec, Alpha Interferon, and Low-Dose Ara-C
ClinicalTrials.gov Identifier: NCT00038649 - Active, not recruiting
Myelogenous Leukemia, Chronic, Chronic Phase
- Long-term Peginterferon alpha-2a Plus Ribavirin to Treat Chronic Hepatitis C in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00076765 - Recruiting
Hepatitis C; HIV Infections
- Iron Supplementation Among Adolescent Girls in India
ClinicalTrials.gov Identifier: NCT00198848 - Recruiting
Iron deficiency anemia
- Treatment of Anemia in the 2nd Year of Life. Comparison of the Efficacy of Two Different Iron Preparations.
ClinicalTrials.gov Identifier: NCT00248716 - Recruiting
Iron Deficiency; Anemia
- Growth Hormone Administration and Its Effects on Cardiovascular Risk Factors in Growth Hormone Deficient Women
ClinicalTrials.gov Identifier: NCT00136032 - Active, not recruiting
Growth Hormone Deficiency; Pituitary Tumor; Pituitary Disease
- Detection and Characterization of Host Defense Defects
ClinicalTrials.gov Identifier: NCT00001355 - Recruiting
Immunologic Deficiency Syndrome; Infection
- Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
ClinicalTrials.gov Identifier: NCT00006054 - Active, not recruiting
Immunologic Deficiency Syndromes; Chediak-Higashi Syndrome; Common Variable Immunodeficiency; Graft Versus Host Disease; ...
- Treatment of Children and Adolescents With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency
ClinicalTrials.gov Identifier: NCT00330668 - Recruiting
Primary IGF-1 Deficiency; Growth Disorders
- The Effect of Early Iron Deficiency on Developmental Brain and Behavior in Infants
ClinicalTrials.gov Identifier: NCT00515918 - Not yet recruiting
Iron Deficiency
- Ig NextGen 10% in Patients With Primary Immune Deficiency (PID)
ClinicalTrials.gov Identifier: NCT00405184 - Recruiting
Primary Immune Deficiency (PID)
- Zinc Deficiency in HIV - 1
ClinicalTrials.gov Identifier: NCT00149552 - Active, not recruiting
HIV; alcohol & drug use; zinc; zinc deficiency
- Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency
ClinicalTrials.gov Identifier: NCT00362063 - Recruiting
Growth Hormone Deficiency
- Prevention of Iron Deficiency in 2nd Year of Life
ClinicalTrials.gov Identifier: NCT00479102 - Not yet recruiting
Iron Deficiency; Anemia
- Beta-Carotene and Alpha-Tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
ClinicalTrials.gov Identifier: NCT00169845 - Active, not recruiting
Neoplasms
- Use of Labeled Glucose to Study Lymphocyte Replication and Survival in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001651 - Recruiting
HIV Infection; Immunologic Deficiency Syndrome
- Endocrine Dysfunction and Growth Hormone Deficiency in Children with Optic Nerve Hypoplasia.
ClinicalTrials.gov Identifier: NCT00140413 - Recruiting
Optic Nerve Hypoplasia; Growth Hormone Deficiency; Septo-Optic dysplasia; Hypopituitarism
- Growth Hormone Deficiency in Chronic Heart Failure: an Observational Study
ClinicalTrials.gov Identifier: NCT00511927 - Recruiting
Ischemic Heart Disease; Dilative Cardiomyopathy; Heart Failure; Growth Hormone Deficiency
- Prevention of Vitamin D Deficiency
ClinicalTrials.gov Identifier: NCT00494104 - Recruiting
Vitamin D Deficiency
- Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease)
ClinicalTrials.gov Identifier: NCT00410566 - Recruiting
Acid Sphingomyelinase Deficiency; Niemann-Pick Disease
- Peginterferon alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00018031 - Recruiting
Hepatitis C; HIV Infections
- Study of Genetic and Molecular Defects in Primary Immunodeficiency Disorders
ClinicalTrials.gov Identifier: NCT00004341 - Active, not recruiting
X-linked agammaglobulinemia; X-linked hyper IgM syndrome; Wiskott-Aldrich Syndrome; Leukocyte Adhesion Deficiency Syndrome
- Investigation of the Human Immune Response in Normal Subjects and Patients with Disorders of the Immune System and Cancer
ClinicalTrials.gov Identifier: NCT00001582 - Recruiting
Communicable Disease; Immunologic Deficiency Syndrome; Neoplasm
- Alberta Physical Activity and Breast Cancer Prevention (ALPHA) Trial
ClinicalTrials.gov Identifier: NCT00522262 - Active, not recruiting
Breast Neoplasms
- Interest of Biofer ® Compound Used in Blédilait Follow on Milk in Infant With Latent Iron Deficiency
ClinicalTrials.gov Identifier: NCT00554814 - Not yet recruiting
Latent Iron Deficiency
- Iodine Status in Pregnant Women and Their Newborns: is Congenital Hypothyroidism Related to Iodine Deficiency in Pregnancy?
ClinicalTrials.gov Identifier: NCT00505479 - Recruiting
Congenital Hypothyroidism; Pregnancy; Iodine Deficiency
- Pegylated Interferon-Alpha-2a in Patients With Malignant Melanoma Stage IIA-IIIB
ClinicalTrials.gov Identifier: NCT00204529 - Active, not recruiting
Melanoma
- Rold of Leptin in the Neuroendocrine and Immune Response to Fasting
ClinicalTrials.gov Identifier: NCT00140231 - Recruiting
energy deficiency associated with short-term fasting
- PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CML
ClinicalTrials.gov Identifier: NCT00303290 - Active, not recruiting
Chronic Myeloid Leukemia
- Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome
ClinicalTrials.gov Identifier: NCT00190658 - Active, not recruiting
Failure to Thrive
- Predictive Markers in GHD and TS Children Treated With SAIZEN®
ClinicalTrials.gov Identifier: NCT00256126 - Active, not recruiting
Growth Hormone Deficiency
- The Role of Vitamins E and C in Maintaining Lung Health in People with Asthma
ClinicalTrials.gov Identifier: NCT00142610 - Active, not recruiting
Asthma
- Efficacy and Safety of Testogel® in Men With Partial Androgen Deficiency of Aging Males (PADAM)
ClinicalTrials.gov Identifier: NCT00185198 - Active, not recruiting
Hypogonadism
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