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Aging Skin |
Liver Spots; Skin Aging |
Clinical Trial: Anastrozole Administration in Elderly Hypogonadal Men
This study is currently recruiting patients.
Verified by National Institute on Aging (NIA) August 2005
|
Purpose
| Condition | Intervention | Phase |
|---|---|---|
| Hypogonadism Aging | Drug: anastrozole | Phase II |
MedlinePlus related topics: Endocrine Diseases
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Expected Total Enrollment: 150
Study start: October 2004; Expected completion: October 2009
It has long been accepted that aging in men is associated with a slow, steady decline in gonadal androgen (male sex hormone) production. Several studies have explored androgen replacement, but the safety and efficacy of testosterone administration remains controversial. Aromatase inhibitors nay provide a particular useful way to restore normal androgen production in aging men.
This study will recruit 150 male volunteers 60 years of age or older to be randomized to receive either anastrozole or a placebo for 24 months. Six visits are planned over the 96-week treatment period.
Eligibility
Inclusion Criteria:
- Men ages 60 and older
- Serum testosterone between 150-300 ng/dL
- Symptoms suggestive of androgen deficiency
Location and Contact Information
Massachusetts
General Clinical Research Center, Massachusetts General Hospital, Boston, Massachusetts, 02114, United States; Recruiting
Sarah Comeaux, BA 617-726-6129 scomeaux@partners.org
Benjamin Z. Leder, MD, Principal Investigator, Massachusetts General Hospital
More Information
Publications
Leder BZ, Rohrer JL, Rubin SD, Gallo J, Longcope C. Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels. J Clin Endocrinol Metab. 2004 Mar;89(3):1174-80.
Taxel P, Kennedy DG, Fall PM, Willard AK, Clive JM, Raisz LG. The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men. J Clin Endocrinol Metab. 2001 Jun;86(6):2869-74.
Last Updated: August 26, 2005
Record first received: August 25, 2005
ClinicalTrials.gov Identifier: NCT00136695
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-08-30
Resources
- Aging Eyelids (American Society For Dermatologic Surgery)
- Aging Skin FAQs (American Academy of Dermatology)
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