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Iodine I-131 Iodocholesterol, its use in adrenal screening - Article


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Adrenal Gland Disorders

Adrenal Disease; Disorder 




Clinical Trial: Iodine I-131 Iodocholesterol, its use in adrenal screening

This study is currently recruiting patients.

Sponsors and Collaborators: M.D. Anderson Cancer Center
University of Michigan
Information provided by: M.D. Anderson Cancer Center

Purpose

This is a clinical research study using I-131 Iodocholesterol which is an experimental radioactive chemical that when injected into the vein, is picked up in the adrenal glands and permits visualization with gamma imaging devices. These images are used in diagnosing a variety of adrenal abnormalities.Prior to the injection of I-131 Iodocholesterol, the patient will receive perchlorate capsules to block any uptake of I-131 by the thyroid gland if this is deemed important. The patient will continue to take these capsules throughout the period of imaging, which may last up to 1 week. The injection of I-131 Iodocholesterol will be given into a vein and the patient will return for images on at least 1 and possibly 2 occasions between 3-7 days after injection. If the case requires it, the patient may also be given a steroid in tablet form, dexamethasone, to take orally prior to and after the injection to suppress normal adrenal function so that the abnormal tissues can be more easily detected.

Condition Treatment or Intervention Phase
Adrenal Gland Diseases
Adrenal Gland Neoplasms
 Drug: I-131 Iodocholesterol
Phase III

MedlinePlus related topics:  Adrenal Gland Disorders;   Cancer;   Cancer Alternative Therapy;   Endocrine Diseases

Study Type: Interventional
Study Design: Diagnostic

Further Study Details: 

Expected Total Enrollment:  125

Study start: December 1988

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Adults with suspected adrenal disease, such as adrenal adenoma, carcinoma, hyperplasia, or Addison's Disease.

Location and Contact Information


Texas
      University of Texas M.D. Anderson Cancer Center, Houston,  Texas,  77030,  United States; Recruiting
Donald A Podoloff, M.D.  713-792-6535    dpodoloff@mdanderson.org 
Anne Stachowiak  713-745-5152    astachow@mdanderson.org 

More Information

Study ID Numbers:  NUM88-001
Record last reviewed:  June 2004
Last Updated:  October 13, 2004
Record first received:  May 23, 2002
ClinicalTrials.gov Identifier:  NCT00037843
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

Resources



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November 25, 2009



Page Updated: September 6, 2005
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