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Clinical Trial: Celecoxib and Radiation Therapy in Treating Patients With Locally Advanced Non-Small Cell Lung Cancer
This study is currently recruiting patients.
Purpose
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Celecoxib may stop the growth of tumor cells by stopping blood flow to the tumor and may make the tumor cells more sensitive to radiation therapy.
PURPOSE: Phase I/II trial to study the effectiveness of combining celecoxib with radiation therapy in treating patients who have locally advanced non-small cell lung cancer.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| stage II non-small cell lung cancer stage IIIA non-small cell lung cancer stage IIIB non-small cell lung cancer | Drug: celecoxib Procedure: anti-cytokine therapy Procedure: antiangiogenesis therapy Procedure: biological response modifier therapy Procedure: enzyme inhibitor therapy Procedure: growth factor antagonist therapy Procedure: radiation therapy | Phase I Phase II |
MedlinePlus related topics: Lung Cancer
Study Type: Interventional
Study Design: Treatment
Official Title: Phase I/II Study of Celecoxib and Limited-Field Radiotherapy in Intermediate-Prognosis Patients With Locally Advanced Non-Small Cell Lung Cancer
Further Study Details:
OBJECTIVES:
- Determine the maximum tolerated dose and the recommended phase II dose of concurrent celecoxib and limited-field radiotherapy in intermediate-prognosis patients with locally advanced non-small cell lung cancer.
- Determine the efficacy and toxicity of this regimen in these patients.
- Determine how the predictors of mortality in the general population (i.e., comorbid conditions, functional status, quality of life, and psychological status) influence prognosis, toxicity, and outcomes of therapy in patients treated with this regimen.
- Correlate circulating levels of vascular endothelial growth factor, basic fibroblast growth factor, and interleukin-8 with survival in patients treated with this regimen.
- Correlate circulating levels of interleukin-1, interleukin-6, and tranforming growth factor-beta with pulmonary toxicity in patients treated with this regimen.
OUTLINE: This is a phase I dose-escalation study of celecoxib followed by a phase II, multicenter study.
- Phase I: Patients receive oral celecoxib twice daily. Beginning on day 6, patients undergo thoracic radiotherapy 5 days a week for 3-6.5 weeks . Patients continue to receive celecoxib for up to 2 years in the absence of disease progression or unacceptable toxicity.
- Phase II: If fewer than 3 of the first 6 patients experience dose-limiting toxicity, then the dose of celecoxib is escalated for all patients in the study, including those in the first cohort. Quality of life is assessed at baseline and at 3, 6, and 12 months after start of therapy.
Patients are followed every 3 months for 1 year, every 6 months for 2 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 6-12 patients will be accrued for the phase I portion of this study and a total of 116 patients will be accrued for the phase II portion of this study within 25 months.
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed non-small cell lung cancer
- Inoperable stage IIB OR
- Unresectable stage IIIA or IIIB
- No evidence of hematogenous metastases
PATIENT CHARACTERISTICS: Age
- 18 and over
Performance status
- Zubrod 2 AND more than 5% weight loss over the past 3 months OR
- Zubrod 0-1 AND less than 5% weight loss over the past 3 months and refuses chemotherapy or are medically unable to tolerate combined modality therapy
Life expectancy
- Not specified
Hematopoietic
- Not specified
Hepatic
- Bilirubin no greater than 2 times upper limit of normal
- INR no greater than 3.0 if taking warfarin
Renal
- Creatinine clearance at least 50 mL/min
Other
- No active gastrointestinal ulcers or bleeding within the past 3 months
- No other malignancy within the past 3 years except nonmelanoma skin cancer
- No known hypersensitivity to celecoxib
- No prior allergic-type reactions to sulfonamides
- No prior asthma, urticaria, or allergic-type reactions to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs)
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY: Biologic therapy
- Not specified
Chemotherapy
- No prior neoadjuvant chemotherapy
- No concurrent chemotherapy
Endocrine therapy
- No concurrent corticosteroids
Radiotherapy
- No prior thoracic radiotherapy
Surgery
- No prior complete or subtotal tumor resection
Other
- No concurrent NSAIDs, lithium, furosemide, or angiotensin-converting enzyme inhibitors
- Concurrent aspirin (325 mg/day) for cardioprotection allowed
Location and Contact Information
Alabama
Comprehensive Cancer Institute, Huntsville, Alabama, 35801, United States; Recruiting
Noel C. Estopinal, MD, FACRO 256-265-6590
DCH Cancer Treatment Center, Tuscaloosa, Alabama, 35401, United States; Recruiting
Melanie D. Graham, MD 205-759-7800
MBCCOP - Gulf Coast, Mobile, Alabama, 36607, United States; Recruiting
John Ronald Russell, MD 251-435-5568
Montgomery Cancer Center, Montgomery, Alabama, 36106-3657, United States; Recruiting
Robert Lee Franklin, MD 334-273-7000
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, 35294-3300, United States; Recruiting
Ruby F. Meredith, MD, PhD 205-934-4763
Arizona
Foundation for Cancer Research and Education, Phoenix, Arizona, 85013, United States; Recruiting
David G. Brachman, MD, FACRO 602-274-4484
California
California Cancer Center - Woodward Park Office, Fresno, California, 93720, United States; Recruiting
Bruce C. McAllister, MD 559-447-4050
CCOP - Bay Area Tumor Institute, Oakland, California, 94609-3305, United States; Recruiting
Brenda M. Shank, MD, PhD 510-456-8570
CCOP - Santa Rosa Memorial Hospital, Santa Rosa, California, 95403, United States; Recruiting
Jay Samuel Joseph, MD 707-525-1150
City of Hope Comprehensive Cancer Center, Duarte, California, 91010-3000, United States; Recruiting
Clinical Trials Office - New Patient Services 800-826-4673 becomingapatient@coh.org
General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base, California, 94535, United States; Recruiting
Roland E. Engel, MD 707-423-7691
Huntington Cancer Center at Huntington Hospital, Pasadena, California, 91105, United States; Recruiting
Ruth C. Williamson, MD 626-535-2421
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, 90095-1714, United States; Recruiting
H. Rodney Withers, MD 310-825-8278
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda, California, 92354, United States; Recruiting
David A. Bush, MD 909-824-4243 dbush@dominion.llumc.edu
Mount Diablo Regional Cancer Center, Concord, California, 94524-4110, United States; Recruiting
Daniel M. Chinn, MD 925-674-2521
Naval Medical Center - San Diego, San Diego, California, 92134-3202, United States; Recruiting
Thomas S. Chung, MD 619-532-7274
O'Connor Hospital, San Jose, California, 95128, United States; Recruiting
Constance Rainer Bowie, MD 408-947-2995
Providence Saint Joseph Medical Center - Burbank, Burbank, California, 91505, United States; Recruiting
Nancy A. Ellerbroek, MD 818-898-4410
Radiation Medical Group, Incorporated, San Diego, California, 92101, United States; Recruiting
Donald B. Fuller, MD 619-230-0400 dfuller@rmgmed.com
Radiation Oncology Centers - Sacramento, Sacramento, California, 95815, United States; Recruiting
Christopher Jones, MD 916-646-6600
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona, California, 91767, United States; Recruiting
Yallapragada S. Rao, MD 909-865-9890
Saint Agnes Cancer Center, Fresno, California, 93720, United States; Recruiting
Madhu Joseph John, MD, FACR, FACRO 209-450-5500
St. Joseph's Regional Cancer Center, Stockton, California, 95204, United States; Recruiting
Henry Y.T. Wong, MD 209-467-6560 hytwong@chw.edu
Sutter Health Western Division Cancer Research Group, Greenbrae, California, 94904, United States; Recruiting
David H. Irwin, MD 510-204-2866
Torrance Memorial Medical Center, Torrance, California, 90505, United States; Recruiting
Thyra Endicott, MD 310-517-4750 thyra.endicott@tmmc.com
UCSF Comprehensive Cancer Center, San Francisco, California, 94115, United States; Recruiting
Janice Ryu, MD 916-734-8251
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, 90033-0804, United States; Recruiting
Oscar E. Streeter, MD 323-865-3084
Veterans Affairs Medical Center - Long Beach, Long Beach, California, 90822, United States; Recruiting
Samar H. Azawi, MD 562-494-5606 samar.azawi@med.va.gov
Colorado
Memorial Hospital Cancer Center, Colorado Springs, Colorado, 80909, United States; Recruiting
Mark Bernard Hazuka, MD 719-365-5800 mark.hazuka@memhospcs.org
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction, Colorado, 81502-1628, United States; Recruiting
Douglas B. Rock, MD 970-244-2442
University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver, Colorado, 80010, United States; Recruiting
Rachel A. Rabinovitch, MD 720-848-0116 rachel.rabinovitch@uchsc.edu
Connecticut
Hospital of Saint Raphael, New Haven, Connecticut, 06511, United States; Recruiting
Joseph G. Cardinale, MD 203-789-3131
Yale Comprehensive Cancer Center, New Haven, Connecticut, 06520-8040, United States; Recruiting
Jonathan P.S. Knisely, MD, FRCPC 203-785-5702 jonathan.knisely@yale.edu
Delaware
CCOP - Christiana Care Health Services, Newark, Delaware, 19713, United States; Recruiting
Christopher D. Koprowski, MD 302-733-1830
District of Columbia
Sibley Memorial Hospital, Washington, District of Columbia, 20016, United States; Recruiting
Gregory S. Sibley, MD 202-537-4787 gsibley@sibley.org
Florida
21st Century Oncology - Fort Myers, Fort Myers, Florida, 33901-8082, United States; Recruiting
Michael Joseph Katin, MD, FACP, FACR, FACRO 239-936-0380 mjkatin@rtsx.com
Baptist-South Miami Regional Cancer Program, Miami, Florida, 33176-2197, United States; Recruiting
Andre A. Abitbol, MD 786-596-6566 andrea@baptisthealth.net
Bay Medical Center, Panama City, Florida, 32401, United States; Recruiting
David B. Hurst, MD 850-747-6972 dhurst@baymedical.org
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, 33140, United States; Recruiting
Michael A. Samuels, MD 305-535-3400 MSamuels@Salick.com
Florida Radiation Oncology Group, Jacksonville, Florida, 32207, United States; Recruiting
Douglas W. Johnson, MD 904-202-7020 djohn005@bmcjax.com
Gulf Coast Cancer Treatment Center, Panama City, Florida, 32405-4587, United States; Recruiting
R. Charles Nichols, MD 850-763-0036 Nicholsmd@aol.com
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida, Tampa, Florida, 33612-9497, United States; Recruiting
Andy M. Trotti, MD 813-972-8424 trotti@moffitt.usf.edu
Holmes Regional Medical Center, Melbourne, Florida, 32901-3276, United States; Recruiting
David L. Grisell, DO 321-434-7179 david.grisell@health-first.org
Sarasota Radiation and Medical Oncology Center, Sarasota, Florida, 34233, United States; Recruiting
W. Jackson Dickens, MD, FACRO 941-924-8700
Tallahassee Memorial Hospital, Tallahassee, Florida, 32308, United States; Recruiting
Timothy W. Bolek, MD 850-431-5255
University of Florida Shands Cancer Center, Gainesville, Florida, 32610-0385, United States; Recruiting
William M. Mendenhall, MD 352-265-0287
University of Miami Sylvester Comprehensive Cancer Center, Miami, Florida, 33136, United States; Recruiting
Arnold Markoe, MD, ScD 305-243-4319 amarkoe@med.miami.edu
Georgia
CCOP - Atlanta Regional, Atlanta, Georgia, 30342-1701, United States; Recruiting
Thomas E. Seay, MD, PhD 404-851-2340
John B. Amos Community Cancer Center, Columbus, Georgia, 31904, United States; Recruiting
Douglas F. Ciuba, MD 706-571-1050
Regional Radiation Oncology Center at Rome, Rome, Georgia, 30165, United States; Recruiting
Matt P. Mumber, MD 706-234-1400 mmumber@rrocrome.com
Winship Cancer Institute of Emory University, Atlanta, Georgia, 30322, United States; Recruiting
Jerome C. Landry, MD 404-778-5180
Hawaii
MBCCOP - Hawaii, Honolulu, Hawaii, 96813, United States; Recruiting
Paul A. DeMare, MD, FACR 808-586-2979
Illinois
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, 60153, United States; Recruiting
Edward Melian, MD 708-216-1588 emelian@lumc.edu
CCOP - Central Illinois, Decatur, Illinois, 62526, United States; Recruiting
James L. Wade, MD 217-876-6617 jlwade3@sbcglobal.net
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois, 60426, United States; Recruiting
Robert E. Share, MD 708-915-6620 Rshare@ingalls.org
Lutheran General Cancer Care Center, Park Ridge, Illinois, 60068, United States; Recruiting
John Han-Chih Chang, MD 847-723-8030 jchang@chicagocancer.org
Methodist Medical Center of Illinois, Peoria, Illinois, 61636, United States; Recruiting
Revathi Swaminathan, MD 309-672-5700 rswaminathan@mmci.org
Northwest Community Hospital, Arlington Heights, Illinois, 60005, United States; Recruiting
Arnold M. Herskovic, MD 847-618-6576 arnoldh134@aol.com
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, 60611-3013, United States; Recruiting
William Small, MD 312-926-6810 w-small@northwestern.edu
Indiana
Bloomington Hospital, Bloomington, Indiana, 47402, United States; Recruiting
David Y. Lee, MD 812-353-9633 dlee@bloomhealth.org
Cancer Center at Ball Memorial Hospital, Muncie, Indiana, 47303-3499, United States; Recruiting
Anthony S. Tilmans, MD 765-747-3827
CCOP - Northern Indiana CR Consortium, South Bend, Indiana, 46601, United States; Recruiting
David A. Hornback, MD 574-647-7370
Community Regional Cancer Care, Indianapolis, Indiana, 46219, United States; Recruiting
Morgan E. Tharp, MD 317-355-5347
Methodist Cancer Center at Methodist Hospital, Indianapolis, Indiana, 46206-1367, United States; Recruiting
Peter G. Garrett, MD 317-962-3172
Oncology Institute of Greater Lafayette, Lafayette, Indiana, 47904, United States; Recruiting
Li-Fen Lien Chang, MD, PhD 765-448-7557 changl@arnett.com
St. John's Cancer Center at St. John's Medical Center, Anderson, Indiana, 46016, United States; Recruiting
James E. Currier, MD 765-649-2511
Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis, Indiana, 46202, United States; Recruiting
Ronald McGarry, MD 317-274-2525 ron.mcgarry@iupui.edu
Iowa
Wendt Regional Cancer Center at Finley Hospital, Dubuque, Iowa, 52001, United States; Recruiting
James R. Baer, MD 563-589-2468
Kentucky
Cancer Center at Lexington Clinic, Lexington, Kentucky, 40504, United States; Recruiting
Mark L. Sobczak, MD 859-258-6505 msobc@lexclin.com
Central Baptist Hospital, Lexington, Kentucky, 40503, United States; Recruiting
Alan Beckman, MD 859-260-6460 abeckman@bhsi.com
Esther Marie Hatton Cancer Care Center at St. Elizabeth Medical Center, Edgewood, Kentucky, 41017, United States; Recruiting
Michael A. Cross, MD 859-344-2238
James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, 40202, United States; Recruiting
Kristie Jones Paris, MD 502-852-7171
Louisville Radiation Oncology Center at Caritas Regional Cancer Center, Louisville, Kentucky, 40215, United States; Recruiting
Mark R. Jones, MD 502-363-3100 raddoc7@bellsouth.net
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington, Kentucky, 40536-0293, United States; Recruiting
Mohammed M. Mohiuddin, MD 859-323-6489 mohmohi@pop.uky.edu
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County, Madisonville, Kentucky, 42431, United States; Recruiting
Satish J. Shah, MD 270-825-5800 sshah@trover.org
Louisiana
CCOP - Ochsner, New Orleans, Louisiana, 70121, United States; Recruiting
Carl G. Kardinal, MD 504-842-3910
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, 70809-3482, United States; Recruiting
Kenneth K. Lo, MD 225-767-0847
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, 70112, United States; Recruiting
Jill Gilbert, MD 504-568-5613 jgilbe@lsuhsc.edu
Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans, Louisiana, 70112-2699, United States; Recruiting
Ellen L. Zakris, MD 504-988-1070 ezakris@tulane.edu
Maine
Maine Medical Center - Bramhall Campus, Portland, Maine, 04102, United States; Recruiting
John R. Mullen, MD 207-871-2276 mullej@spectrummg.com
Maryland
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore, Maryland, 21215, United States; Recruiting
Mark Joel Brenner, MD, FACR 410-601-5689 mbrenner@lifebridgehealth.org
Cancer Center at Greater Baltimore Medical Center, Baltimore, Maryland, 21204, United States; Recruiting
Robert K. Brookland, MD 443-849-2540
DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis, Maryland, 21401, United States; Recruiting
Angel E. Torano, MD 443-481-5800
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, 21201, United States; Recruiting
Mohan Suntharalingam, MD 410-328-2331 msunthar@umm.edu
Harbor Hospital Center, Baltimore, Maryland, 21215-1290, United States; Recruiting
Jack J. Hong, MD 410-355-0868 jack.j.hong@medstar.net
Peninsula Regional Medical Center, Salisbury, Maryland, 21801, United States; Recruiting
Scott A. Edwards, MD 410-543-7000 scott.edwards@peninsula.org
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, 21231-2410, United States; Recruiting
Ding-Jen Lee, MD 410-955-8062 leedj@jhmi.edu
St. Agnes Cancer Center, Baltimore, Maryland, 21229, United States; Recruiting
Richard S. Hudes, MD 410-368-2965 rhudes@stagnes.org
Massachusetts
Cancer Research Center at Boston Medical Center, Boston, Massachusetts, 02118, United States; Recruiting
Steven Lane, MD 617-638-7070
Cape Cod Hospital, Hyannis, Massachusetts, 02601, United States; Recruiting
Martin Ivan Holzman, MD 508-862-5309 mkholzman@yahoo.com
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston, Massachusetts, 02114, United States; Recruiting
William U. Shipley, MD, FACR 617-726-8146
NSMC Cancer Center - Peabody, Peabody, Massachusetts, 01960, United States; Recruiting
Eric Taylor Weber, MD 978-977-9400
South Suburban Oncology Center, Quincy, Massachusetts, 02169, United States; Recruiting
Bruce B. Borgelt, MD, PhD 617-376-6400
Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain, Massachusetts, 02130, United States; Recruiting
Richard H. Matthews, MD, PhD 617-232-9500, ext. 5628
Michigan
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201, United States; Recruiting
Harold E. Kim, MD 313-966-0556 kimh@kci.wayne.edu
CCOP - Beaumont, Royal Oak, Michigan, 48073-6769, United States; Recruiting
John M. Robertson, MD 248-551-7038
CCOP - Kalamazoo, Kalamazoo, Michigan, 49007-3731, United States; Recruiting
Raymond Sterling Lord, MD 269-373-7488 rlord@wmcc.org
CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan, 48106, United States; Recruiting
Miljenko V. Pilepich, MD 877-590-5995
Great Lakes Cancer Institute at McLaren Regional Medical Center, Flint, Michigan, 48532-3685, United States; Recruiting
Hesham E. Gayar, MD 810-342-3800 hgayar@aol.com
Hurley Medical Center, Flint, Michigan, 48503, United States; Recruiting
Ahmed Mohamed Akl, MD 810-257-9422
Josephine Ford Cancer Center at Henry Ford Health System, Detroit, Michigan, 48202, United States; Recruiting
Munther Isa Ajlouni, MD 313-916-1026 majloun1@hfhs.org
MidMichigan Medical Center - Midland, Midland, Michigan, 48670, United States; Recruiting
Paul G. Kocheril, MD 989-839-3450
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109-0010, United States; Recruiting
Howard Mark Sandler, MD 734-936-9338 hsandler@umich.edu
Upper Michigan Cancer Center at Marquette General Hospital, Marquette, Michigan, 49855, United States; Recruiting
Paul O. Thieme, DO 906-225-3102
William Beaumont Hospital - Royal Oak, Royal Oak, Michigan, 48073, United States; Recruiting
John M. Robertson, MD 248-551-7038 jrobertson@beaumont.edu
William Beaumont Hospital - Troy, Troy, Michigan, 48085, United States; Recruiting
Richard C. Matter, MD 248-964-6156
Minnesota
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, 55416, United States; Recruiting
Paul Sperduto, MD 952-442-6000
Fairview University Medical Center - University Campus, Minneapolis, Minnesota, 55455, United States; Recruiting
Chung K. Lee, MD 612-273-6700 leexx006@umn.edu
Mayo Clinic Cancer Center, Rochester, Minnesota, 55905-0001, United States; Recruiting
Michael G. Haddock, MD 507-284-2511
Missouri
CCOP - Cancer Research for the Ozarks, Springfield, Missouri, 65807, United States; Recruiting
John W. Clouse, MD 417-269-4520
CCOP - Kansas City, Kansas City, Missouri, 64131, United States; Recruiting
William T. Stephenson, MD 816-823-0555
Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia, Missouri, 65203, United States; Recruiting
Mark P. Bryer, MD 573-442-5525
Saint Louis University Cancer Center, Saint Louis, Missouri, 63110-0250, United States; Recruiting
Oscar D. Norton, MD 314-577-8815
Siteman Cancer Center at Barnes-Jewish Hospital, St. Louis, Missouri, 63110, United States; Recruiting
Jeff M. Michalski, MD 314-747-7222 michalski@radonc.wustl.edu
Montana
CCOP - Montana Cancer Consortium, Billings, Montana, 59101, United States; Recruiting
Robert D. Pfeffer, MD 406-259-2245
Nebraska
CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska, 68106, United States; Recruiting
Patrick J. McKenna, MD 402-991-8070
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha, Nebraska, 68114-4199, United States; Recruiting
James A. Wheeler, MD 402-354-4104 jwheele@nmhs.org
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha, Nebraska, 68198-7521, United States; Recruiting
Robert Bruce Thompson, MD 402-559-3848
Nevada
CCOP - Southern Nevada Cancer Research Foundation, Las Vegas, Nevada, 89106, United States; Recruiting
Raul T. Meoz-Mendez, MD, FACR 702-384-0013
New Hampshire
Elliot Regional Cancer Center, Manchester, New Hampshire, 03103, United States; Recruiting
Andrea McKee, MD 603-663-1800
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, 03756-0002, United States; Recruiting
Eugen B. Hug, MD 603-650-6600 eugen.hug@hitchcock.org
New Jersey
Associated Radiologists, P.A. at Warren Radiation Therapy Center, Warren, New Jersey, 07059, United States; Recruiting
Laura R. Bond, MD 908-769-5999
Atlantic City Medical Center - Mainland Division, Pomona, New Jersey, 08240, United States; Recruiting
Jorge F. Cassir, MD 609-652-3417
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick, New Jersey, 08903, United States; Recruiting
David T. Marshall, MD 732-235-8590
Community Medical Center, Toms River, New Jersey, 08755, United States; Recruiting
Bong M. Chang, MD 732-557-8148 BChang@sbhcs.com
Fox Chase Cancer Center at St. Francis Medical Center, Trenton, New Jersey, 08629, United States; Recruiting
Jo Ann Chalal, MD 609-599-5179 Jchalalm.d@che-east.org
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital - Marlton, Mount Holly, New Jersey, 08060, United States; Recruiting
Lemuel S. Ariaratnam, MD 609-261-7074 lariaratnam@virtua.org
John F. Kennedy Medical Center, Edison, New Jersey, 08818, United States; Recruiting
Mark S. Macher, MD 732-321-7167 mmacher@solarishs.org
Monmouth Medical Center, Long Branch, New Jersey, 07740-6395, United States; Recruiting
Sang Sim 732-923-6575
Newark Beth Israel Medical Center, Newark, New Jersey, 07112, United States; Recruiting
Robert Ivker, DO 973-926-7320 rivker@sbhcs.com
South Jersey Regional Cancer Center, Millville, New Jersey, 08332, United States; Recruiting
Joseph W. Fanelle, MD 856-293-2910 fanellej@sjhs.com
Trinitas Hospital - Jersey Street Campus, Elizabeth, New Jersey, 07201, United States; Recruiting
Eli D. Finkelstein, MD 908-994-8393 efinkelstein@trinitas.org
University Medical Center of Princeton, Princeton, New Jersey, 08540, United States; Recruiting
Robert Michael Cardinale, MD 609-497-4304
Valley Hospital - Ridgewood, Ridgewood, New Jersey, 07450, United States; Recruiting
David Robert Greenblatt, MD 201-447-8220 dgreenb@valleyhealth.com
Veterans Affairs Medical Center - East Orange, East Orange, New Jersey, 07018, United States; Recruiting
Basil S. Kasimis, MD, DSc 973-676-1000 ext. 7095 Basil.Kasimis@med.va.gov
New Mexico
Radiation Oncology Associates of Albuquerque, Albuquerque, New Mexico, 87109, United States; Recruiting
Paul A. Anthony, MD 505-727-7900
New York
Beth Israel Medical Center - Philipps Ambulatory Care Center, New York, New York, 10003, United States; Recruiting
Manjeet Chadha, MD 212-844-8042 mchadha@bethisraelny.org
CCOP - North Shore University Hospital, Manhasset, New York, 11030, United States; Recruiting
Sophie S. Turner, MD, FACR 516-562-8900
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., East Syracuse, New York, 13057, United States; Recruiting
N. F. Mariados, MD 315-472-7504
Champlain Valley Physicians Hospital Medical Center, Plattsburgh, New York, 12901-1490, United States; Recruiting
Anthony Vaccaro, MD 518-562-7120 drv@adkradiation.com
Dyson Center for Cancer Care at Vassar Brothers Medical Center, Poughkeepsie, New York, 12601, United States; Recruiting
Taik H. Kim, MD 914-454-2372 tkim@health-quest.org
Finger Lakes Radiation Oncology Center, Clifton Springs, New York, 14432, United States; Recruiting
Sidney H. Sobel, MD, FACR 315-462-5711
Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York, 10032, United States; Recruiting
Peter B. Schiff, MD, PhD 212-305-8096
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, 14642, United States; Recruiting
Paul Okunieff, MD 585-275-5575 paul_okunieff@urmc.rochester.edu
Lourdes Regional Cancer Center, Binghamton, New York, 13905, United States; Recruiting
Michael Fallon, MD 607-798-5111
Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, United States; Recruiting
Bruce David Minsky, MD 212-639-6817 minskyb@.mskcc.org
New York Methodist Hospital, Brooklyn, New York, 11215-3609, United States; Recruiting
Sameer Rafla-Demetrious, MD, PhD, FRCR, FACR, FRSM 718-780-3677 sar9003@nyp.org
North Shore Radiation Oncology, Setauket, New York, 11733, United States; Recruiting
Martin J. Silverstein, MD 631-246-5860
Riverhill Radiation Oncology, Yonkers, New York, 10701, United States; Recruiting
Arthur D. Brimberg, MD 914-969-1600 abrimberg@rtsx.com
SUNY Downstate Medical Center, Brooklyn, New York, 11203, United States; Recruiting
Marvin Rotman, MD 718-270-2181 mrotman@downstate.edu
SUNY Upstate Medical University Hospital, Syracuse, New York, 13210, United States; Recruiting
Chung-Taik Chung, MD 315-464-5276 chungc@upstate.edu
North Carolina
Batte Cancer Center at Northeast Medical Center, Concord, North Carolina, 28025, United States; Recruiting
Scott P. Lankford, MD 704-783-1577
CCOP - Southeast Cancer Control Consortium, Goldsboro, North Carolina, 27534-9479, United States; Recruiting
James N. Atkins, MD 336-777-3088
Comprehensive Cancer Center at Wake Forest University, Winston Salem, North Carolina, 27157-1082, United States; Recruiting
Kathryn McConnell Greven, MD 336-716-4464
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital, Greenville, North Carolina, 27835-6028, United States; Recruiting
Kalika P. Sarma, MD 252-744-2900
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, 27599-7295, United States; Recruiting
Lav K. Goyal, MD 919-966-7700 lav-goyal#med.unc.edu
North Dakota
Trinity Cancer Care Center, Minot, North Dakota, 58701, United States; Recruiting
Kevin Basil Collins, MD 701-857-3535 kevin.collins@trinityhealth.org
Ohio
Akron City Hospital at Summa Health System, Akron, Ohio, 44304, United States; Recruiting
William F. Demas, MD 330-375-3557 demasw@summa-health.org
Akron General's McDowell Cancer Center, Akron, Ohio, 44302, United States; Recruiting
Mitchell Lee Fromm, MD 330-344-6448 mfromm@agmc.org
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University, Columbus, Ohio, 43210-1240, United States; Recruiting
Reinhard A. Gahbauer, MD 614-293-8415 gahbauer.1@osu.edu
Cancer Center at Christ Hospital, Cincinnati, Ohio, 45219, United States; Recruiting
Ralph J. Wright, MD 513-585-2734
CCOP - Columbus, Columbus, Ohio, 43206, United States; Recruiting
Lawrence B. Berk, MD, PhD 614-566-9506
CCOP - Dayton, Dayton, Ohio, 45429, United States; Recruiting
Howard M. Gross, MD 937-832-1093
CCOP - Toledo Community Hospital, Toledo, Ohio, 43623-3456, United States; Recruiting
Paul L. Schaefer, MD 419-843-6147
Charles M. Barrett Cancer Center at University Hospital, Cincinnati, Ohio, 45219, United States; Recruiting
Kevin P. Redmond, MD 513-584-9089 redmonkp@healthall.com
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, 44195, United States; Recruiting
John H. Suh, MD 216-444-5574 suhj@ccf.org
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, 44106-5065, United States; Recruiting
Adir Ludin, MD 216-844-5432
Parma Community General Hospital, Parma, Ohio, 44129, United States; Recruiting
Anthony Mastroianni, MD, JD 440-743-4749
Oklahoma
CCOP - Oklahoma, Tulsa, Oklahoma, 74136, United States; Recruiting
Robert G. Swanson, MD 918-494-1585 rgswanson@saintfrancis.com
Frank C. Love Cancer Institute at St. Anthony Hospital, Oklahoma City, Oklahoma, 73102, United States; Recruiting
Marianne M. Young, MD 405-272-7311
LaFortune Cancer Center at St. John Health System, Tulsa, Oklahoma, 74104, United States; Recruiting
Diane Heaton, MD 918-744-2071 dheaton@sjmc.org
Oklahoma University Medical Center, Oklahoma City, Oklahoma, 73104, United States; Recruiting
Joseph F. Montebello, MD 405-271-4022
Oregon
CCOP - Columbia River Oncology Program, Portland, Oregon, 97225, United States; Recruiting
Keith S. Lanier, MD 503-216-6260
Pennsylvania
Abington Memorial Hospital, Abington, Pennsylvania, 19001, United States; Recruiting
David Horvick, MD 215-481-2800 dhorvick@amh.org
Abramson Cancer Center at the University of Pennsylvania, Philadelphia, Pennsylvania, 19104-4283, United States; Recruiting
Mitchell Machtay, MD 215-662-2428 machtay@xrt.upenn.edu
Albert Einstein Cancer Center, Philadelphia, Pennsylvania, 19141-3098, United States; Recruiting
Sucha O. Asbell, MD 215-456-6280
Allegheny General Hospital, Pittsburgh, Pennsylvania, 15212-4772, United States; Recruiting
David S. Parda 412-359-8084 dparda@wpahs.org
CCOP - MainLine Health, Wynnewood, Pennsylvania, 19096, United States; Recruiting
Albert S. DeNittis, MD 610-645-2433 denittisa@mlhs.org
Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg, Pennsylvania, 18301, United States; Recruiting
Michael J. Greenberg, MD 570-476-3488 mgreenb798@aol.com
Delaware County Regional Cancer Center at Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, 19026, United States; Recruiting
Rachelle M. Lanciano, MD 610-284-8240 RLancmd@aol.com
Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States; Recruiting
Benjamin Movsas, MD 215-728-5304 b_movsas@fccc.edu
Geisinger Medical Center, Danville, Pennsylvania, 17822-0001, United States; Recruiting
A. Douglas Christie, MD 570-271-6304 achristie@geisiger.edu
Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15232, United States; Recruiting
John M. Varlotto, MD 412-623-4000
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown, Pennsylvania, 18105-1556, United States; Recruiting
Victor R. Risch, MD 610-402-0700 victor.risch@lvh.com
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, 19107-5541, United States; Recruiting
Walter John Curran, MD 215-955-6700
Mercy Fitzgerald Hospital, Darby, Pennsylvania, 19023, United States; Recruiting
Leslie Tupchong, MD, PhD, FACR, MMM, CPE 610-237-4370 Ltupchong@mercyhealth.org
Mercy Hospital Cancer Center - Scranton, Scranton, Pennsylvania, 18501, United States; Recruiting
Harmar D. Brereton, MD 570-348-7200 brereton@epix.net
Mercy Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15219, United States; Recruiting
Michael J. Dougherty, MD 412-232-7475
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey, Pennsylvania, 17033-0850, United States; Recruiting
David J. Salinger, MD 717-531-1523 dsalinger@psu.edu
Reading Hospital and Medical Center, Reading, Pennsylvania, 19612-6052, United States; Recruiting
Albert Yuen, MD 610-988-8067
St. Luke's Hospital Cancer Center, Bethlehem, Pennsylvania, 18015, United States; Recruiting
Nimisha Deb, MD 610-954-4300 DebN@slhn.org
Veterans Affairs Medical Center - Philadelphia, Philadelphia, Pennsylvania, 19104, United States; Recruiting
Mitchell Machtay, MD 215-382-2401
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, 15224, United States; Recruiting
Judith H. Figura, MD 412-578-1923 jhfigura2@wpahs.org
Wilkes-Barre General Hospital, Wilkes Barre, Pennsylvania, 18764-0001, United States; Recruiting
Clinical trial summary from the National Cancer Institute's PDQ® database
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
Study ID Numbers: CDR0000069476; RTOG-0213; NCT00046839
Record last reviewed: December 2004
Last Updated: March 28, 2005
Record first received: October 3, 2002
ClinicalTrials.gov Identifier: NCT00046839
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Record last reviewed: December 2004
Last Updated: March 28, 2005
Record first received: October 3, 2002
ClinicalTrials.gov Identifier: NCT00046839
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
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