The neurofibromatoses are genetic disorders of the nervous system that primarily affect the development and growth of neural (nerve) cell tissues. These disorders cause tumors to grow on nerves and produce other abnormalities such as skin changes and bone deformities. Although many affected persons inherit the disorder, between 30 and 50 percent of new cases arise spontaneously through mutation (change) in an individual's genes. Once this change has taken place, the mutant gene can be passed on to succeeding generations.

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... Neurofibromatosis is a condition in which noncancerous tumors called neurofibromas grow along nerves in the skin, brain, and other parts of the body. The two main types of neurofibromatosis can be distinguished by the locations of the tumors and by genetic testing.

Genetic changes are related to the following types of neurofibromatosis.

  • neurofibromatosis 1
  • neurofibromatosis 2

The features of neurofibromatosis depend on where the tumors are located and differ for each type of the condition. Sometimes the signs and symptoms are so mild that individuals may be unaware of having this disorder. In other cases, signs and symptoms can be very serious or life-threatening. For a discussion of specific features, please refer to the summaries for neurofibromatosis 1 and neurofibromatosis 2. ...

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Neurofibromatosis is an autosomal dominant genetic disorder. Types Ther ...
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Neurofibromatosis Other

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Neurofibomatosis
... What is neurofibromatosis? Neurofibromatoses are genetic disorders of the nervous system. Mainly, these disorders affect the growth and development of nerve cell tissue. The disorders are known as neu...
Source: Cleveland Clinic

The Neurofibromatoses
... What are the neurofibromatoses? The neurofibromatoses are genetic disorders of the nervous system that primarily affect the development and growth of neural (nerve) cell tissues. These disorders cause...
Source: Cleveland Clinic

   

Neurofibromatosis Articles

  • Genes and Disease: Neurofibromatosis
    ... Neurofibromatosis, type 2, (NF-2) is a rare inherited disorder characterized by the development of benign tumors on both auditory nerves (acoustic neuromas). The disease is also characterized by the d...
  • Neurofibromatosis
    ... Neurofibromatosis is a condition in which noncancerous tumors called neurofibromas grow along nerves in the skin, brain, and other parts of the body. The two main types of neurofibromatosis can be dis...
  • Neurofibromatosis Fact Sheet
    ... The neurofibromatoses are genetic disorders of the nervous system that primarily affect the development and growth of neural (nerve) cell tissues. These disorders cause tumors to grow on nerves and pr...
  • Neurofibromatosis Information Page
    ... The neurofibromatoses are genetic disorders of the nervous system that primarily affect the development and growth of neural (nerve) cell tissues. These disorders cause tumors to grow on nerves and pr...
  • Tumor Grade: Questions and Answers
    ... Key Points Tumor grade is a system used to classify cancer cells in terms of how abnormal they look under a microscope and how quickly the tumor is likely to grow and spread (see Question 2). A pathol...
  • Vestibular Schwannoma (Acoustic Neuroma) and Neurofibromatosis
    ... A vestibular schwannoma (also known as acoustic neuroma, acoustic neurinoma, or acoustic neurilemoma) is a benign, usually slow-growing tumor that develops from the balance and hearing nerves supplyin...

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