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The Influences of Malnutrition and Inflammation Complex Syndrome in Hemodialysis Patients - Article


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International Micronutrient Malnutrition Prevention & Control Program

IMMPaCt 



Clinical Trial: The Influences of Malnutrition and Inflammation Complex Syndrome in Hemodialysis Patients

This study is not yet open for patient recruitment.
Verified by Far Eastern Memorial Hospital August 2005

Sponsors and Collaborators: Far Eastern Memorial Hospital
National Taiwan University
Information provided by: Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT00190125

Purpose

To explore the severity of malnutrition and inflammation in Taiwanese hemodialysis patients.
Condition
Hemodialysis
Malnutrition
Inflammation
Myocardial Ischemia
Cerebrovascular Accident

MedlinePlus related topics:  Heart Diseases;   Nutrition;   Stroke;   Vascular Diseases

Study Type: Observational
Study Design: Natural History, Longitudinal, Defined Population, Prospective Study

Further Study Details: 

Expected Total Enrollment:  300

Study start: September 2005;  Expected completion: September 2007
Last follow-up: August 2007;  Data entry closure: August 2007

Cardiovascular disease is the major of cause of mortality of hemodialysis patients. In addition to diabetes and hypertension, malnutrition and chronic inflammation are well-known to be major risk factors of cardiovascular diseases in normal population. For detecting the malnutrition and chronic inflammation and understanding the exact inluencs to hemodialysis patients, we conduct this study. We will collect the biochemical parameters, inflammatory markers, lipid parameters, hematologic parameters,and genomic DNA of patients. Then we will prospectively record the hospitalization, cardiovascular events, complications of artiovenous fistula/graft, and mortality. According to the above results, we try to explore the exact role of malnutrition and inflammation in hemodialysis patients.

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both
Criteria

Inclusion Criteria:

  • Patients had received hemodialysis therapy for more than three months

Exclusion Criteria:

  • Having active infection diseases now
  • Patients have malignanacy
  • Having cardiovascular events in recent three months

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00190125

Yu-Sen Peng, M.D.      886-2-89667000  Ext. 1514    taan70@yahoo.com.tw
Chih-Kang Chiang, M.D.      886-2-23123456  Ext. 3923    ckchiang@mail.femh.org.tw

Taiwan
      Far Eastern Memorial Hospital, Pan-Chiao, Taipei country,  220,  Taiwan
Yu-Sen Peng, M.D.  886-89667000  Ext. 1514    taan70@yahoo.com.tw 
Chih-Kang Chiang, M.D.,  Sub-Investigator

Study chairs or principal investigators

Yu-Sen Peng, M.D.,  Principal Investigator,  Far Eastern Memorial Hospital   

More Information

Publications

Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis. 2003 Nov;42(5):864-81. Review.

Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH. Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis. J Am Soc Nephrol. 2001 Dec;12(12):2797-806.

Kalantar-Zadeh K, McAllister CJ, Lehn RS, Lee GH, Nissenson AR, Kopple JD. Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. Am J Kidney Dis. 2003 Oct;42(4):761-73.

Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004 Aug;80(2):299-307.

Kalantar-Zadeh K, Mehrotra R, Fouque D, Kopple JD. Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure. Semin Dial. 2004 Nov-Dec;17(6):455-65. Review.

Study ID Numbers:  FEMH-94008
Last Updated:  September 16, 2005
Record first received:  September 11, 2005
ClinicalTrials.gov Identifier:  NCT00190125
Health Authority: Taiwan: Department of Health
ClinicalTrials.gov processed this record on 2005-09-20


Source: ClinicalTrials.gov
Cache Date: September 21, 2005


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November 26, 2009


Page Updated: January 17, 2009
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